Volume 15, Number 7—July 2009
Research
Relapse Associated with Active Disease Caused by Beijing Strain of Mycobacterium tuberculosis1
William J. Burman
, Erin E. Bliven, Lauren Cowan, Lorna Bozeman, Payam Nahid, Lois Diem, Andrew Vernon, and for the Tuberculosis Trials Consortium
, Erin E. Bliven, Lauren Cowan, Lorna Bozeman, Payam Nahid, Lois Diem, Andrew Vernon, and for the Tuberculosis Trials ConsortiumTable 3
Association between active disease caused by a Beijing genotype of Mycobacterium tuberculosis and relapse, adjusted for clinical risk factors, Tuberculosis Trials Consortium Study 22*
| Characteristic | Univariate analysis |
Multivariate analysis |
|||
|---|---|---|---|---|---|
| Odds ratio (95% CI) | p value | Odds ratio (95% CI) | p value | ||
| Infected with Beijing genotype | 2.0 (1.0–4.0) | 0.05 | 2.2 (1.0–4.9) | 0.07 | |
| Non-Hispanic white race/ethnicity | 3.3 (1.7–6.1) | <0.01 | 3.0 (1.4–6.7) | <0.01 | |
| Underweight at tuberculosis diagnosis | 4.7 (2.6–8.6) | <0.01 | 3.7 (1.8–7.2) | <0.01 | |
| Pulmonary cavitation | 5.0 (2.4–10.7) | <0.01 | 3.2 (1.4–7.5) | 0.01 | |
| Bilateral pulmonary disease | 2.9 (1.5–5.7) | <0.01 | 1.8 (0.9–4.0) | 0.12 | |
| Two-month sputum culture positivity | 4.7 (2.6–8.7) | <0.01 | 2.4 (1.2–4.9) | 0.01 | |
*The Tuberculosis Trials Consortium Study enrolled patients during 1995–1998. Participants in the case–control study were selected from among 1,004 HIV-infected participants. CI, confidence interval.
