Volume 15, Number 9—September 2009
Research
Susceptibilities of Nonhuman Primates to Chronic Wasting Disease
Brent Race1
, Kimberly D. Meade-White1, Michael W. Miller, Kent D. Barbian, Richard Rubenstein, Giuseppe LaFauci, Larisa Cervenakova, Cynthia Favara, Donald Gardner, Dan Long, Michael Parnell, James Striebel, Suzette A. Priola, Anne Ward, Elizabeth S. Williams2, Richard Race3, and Bruce Chesebro3
, Kimberly D. Meade-White1, Michael W. Miller, Kent D. Barbian, Richard Rubenstein, Giuseppe LaFauci, Larisa Cervenakova, Cynthia Favara, Donald Gardner, Dan Long, Michael Parnell, James Striebel, Suzette A. Priola, Anne Ward, Elizabeth S. Williams2, Richard Race3, and Bruce Chesebro3Table 4
PrP sequence variability in squirrel monkeys*
| Genotype† | No. monkeys | PrP gene variations‡ |
||
|---|---|---|---|---|
| Residue 19 | No. octapeptide repeats | Residue 164 | ||
| A | 16 | Leu/Leu | 5/5 | Lys/Lys |
| B | 5 | ND | 4/5 | Lys/Lys |
| C | 2 | Val/Leu | 5/5 | Lys/Lys |
| Schätzl | 1 | Leu/Leu | 5/5 | Arg/Arg |
| Schneider | 1 | ND | 4/4 | Arg/Arg |
*PrP, prion protein; ND, not determined.
†The PrP genes of 23 monkeys were sequenced, and 3 genotypes were found. For easy reference to Tables 1 and 2, they are designated types A, B, and C. Previous squirrel monkey PrP sequences were identified by Schätzl et al. (28) and Schneider et al. (31).
‡Compared with published sequences, PrP genotype variations were seen only at residue 19 (in the signal peptide), residue 164, and in the number of octapeptide repeats.
