Volume 16, Number 11—November 2010
Research
Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada
Sonia Toracchio, Annette Foyle, Vojtech Sroller1, Jon A. Reed, Jun Wu, Claudia A. Kozinetz, and Janet S. Butel
Table 4
Presence of MCPyV in benign lymph nodes, lymph nodes with metastatic cancer, and other inflammatory or neoplastic tissues, Nova Scotia, Canada, 1994–2001*
| Pathologic feature | No. samples tested | No. (%) MCPyV positive |
|---|---|---|
| Benign lymph nodes | 110 | 11 (10) |
| Acute lymphadenitis | 1 | 0 |
| Atypical hyperplasia | 2 | 0 |
| Dermatopathic lymphadenopathy | 3 | 0 |
| Florid follicular hyperplasia | 1 | 0 |
| Mycobacterium avium–intracellulare infection | 2 | 0 |
| Necrotizing granulomas | 3 | 0 |
| Normal lymph node | 29 | 3 (10.3) |
| Reactive hyperplasia | 61 | 8 (13.1) |
| Sarcoidosis | 6 | 0 |
| Systemic mast cell disease | 1 | 0 |
| Toxoplasmosis |
1 |
0 |
| Lymph nodes with metastatic tumors | 27 | 0 |
| Carcinoma | 25 | 0 |
| Melanoma |
2 |
0 |
| Other inflammatory tissues | 7 | 0 |
| Chronic sialadenitis | 1 | 0 |
| Follicular bronchiolitis | 1 | 0 |
| Hemophagocytic syndrome, spleen | 1 | 0 |
| Helicobacter pylori–associated gastritis | 1 | 0 |
| Hemochromatosis, liver | 1 | 0 |
| Hyperplasia and chronic perifolliculitis, skin | 1 | 0 |
| Interstitial pneumonitis |
1 |
0 |
| Other neoplastic tissues | 13 | 0 |
| Mixed mullerian tumor | 1 | 0 |
| Neurofibroma | 1 | 0 |
| Sarcoma | 4 | 0 |
| Schwannoma | 2 | 0 |
| Thymoma | 5 | 0 |
*MCPyV, Merkel cell polyomavirus.
