Genetic Structure of Plasmodium falciparum and Elimination of Malaria, Comoros Archipelago
Stanislas Rebaudet1, Hervé Bogreau1, Rahamatou Silaï, Jean-François Lepère, Lionel Bertaux, Bruno Pradines, Jean Delmont, Philippe Gautret, Philippe Parola, and Christophe Rogier
Author affiliations: Institute for Biomedical Research of the French Army, Marseille, France (S. Rebaudet, H. Bogreau, L. Bertaux, B. Pradines, C. Rogier); Université de la Méditerranée, Marseille (J. Delmont, P. Parola); Assistance Publique–Hôpitaux de Marseille, Marseille (P. Gautret); Programme National de Lutte contre le Paludisme, Moroni, Comoros (R. Silaï); Dispensaire de Bandraboua, Mayotte, France (J.-F. Lepère); 1These authors contributed equally to this article.
Figure 2. Genetic differentiation (Fst) between Plasmodium falciparum populations from the islands of Grande Comore (GC), Moheli (MOH), Anjouan (ANJ), and Mayotte (MAY) and from Marseille, France (MARS), according to 6 microsatellite loci. Pairwise comparison among sites that used complete dataset (n = 281) and 6 microsatellite loci (Pf2689, C4M79, Pf2802, 7A11, TRAP, and C4M69). Departure of FST from 0 tested after 10,000 bootstrap simulations and by using Bonferroni corrected p values obtained after 200 permutations. Difference is significant if adjusted p<0.005. Black arrows indicate negligible (FST<0.01) and nonsignificant differentiation. Asterisks (*) and orange arrows indicate moderate (0.01<FST<0.1) and/or statistically significant differentiation. Daggers (†) and red arrows indicate important (FST>0.1) and significant differentiation. Plain arrows indicate genetic differentiation between the parasite populations of the Comoros islands. Dotted arrows indicate genetic differentiation between the parasite population imported in Marseille (from Comoros) and either the overall parasite population of the entire Comoros archipelago (dotted oval and extreme right arrow) or the parasite populations of each of the 4 islands.
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