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Volume 16, Number 11—November 2010

Research

Genetic Structure of Plasmodium falciparum and Elimination of Malaria, Comoros Archipelago

Stanislas Rebaudet1, Hervé Bogreau1, Rahamatou Silaï, Jean-François Lepère, Lionel Bertaux, Bruno Pradines, Jean Delmont, Philippe Gautret, Philippe Parola, and Christophe RogierComments to Author 
Author affiliations: Institute for Biomedical Research of the French Army, Marseille, France (S. Rebaudet, H. Bogreau, L. Bertaux, B. Pradines, C. Rogier); Université de la Méditerranée, Marseille (J. Delmont, P. Parola); Assistance Publique–Hôpitaux de Marseille, Marseille (P. Gautret); Programme National de Lutte contre le Paludisme, Moroni, Comoros (R. Silaï); Dispensaire de Bandraboua, Mayotte, France (J.-F. Lepère); 1These authors contributed equally to this article.

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Table 5

Frequency of chemoresistance-associated point mutations of 5 sites studied for Plasmodium falciparum malaria, Comoros archipelago and Marseille, France*

Locus No. isolates (% mutations)
Grande Comore Moheli Anjouan Mayotte Marseille
Pfcrt
76T 33 (45.5) 33 (45.5) 36 (13.9) 36 (91.7) 36 (52.8)
76 T and K 33 (9.1) 33 (6.1) 36 (5.6) 36 (2.8) 36 (0)
K76 (Wt)
33 (45.5)
33 (48.5)
36 (80.6)
36 (5.6)
36 (47.2)
Pfdhfr
108N 26 (50.0) 19 (84.2) 34 (38.2) 36 (50.0) 36 (80.6)
108 N and S 26 (15.4) 19 (5.3) 34 (11.8) 36 (0) 36 (2.8)
S108 (Wt) 26 (34.6) 19 (10.5) 34 (50.0) 36 (50.0) 36 (16.7)
59R 26 (50.0) 19 (78.9) 34 (26.5) 36 (44.4) 36 (77.8)
59 R and C 26 (7.7) 19 (10.5) 34 (11.8) 36 (0) 36 (2.8)
C59 (Wt) 26 (42.3) 19 (10.5) 34 (61.8) 36 (55.6) 36 (19.4)
51I 26 (38.5) 19 (63.2) 34 (23.5) 36 (44.4) 35 (65.7)
51 I and N 26 (11.5) 19 (5.3) 34 (2.9) 36 (0) 35 (2.9)
N51 (Wt) 26 (50.0) 19 (31.6) 34 (73.5) 36 (55.6) 35 (31.4)
108N and 59R 26 (57.7) 19 (89.5) 34 (38.2) 36 (44.4) 36 (80.6)
108N and 59R and 51I
26 (50.0)
19 (68.4)
34 (26.5)
36 (44.4)
35 (68.6)
Pfdhps
437G 25 (4.0) 24 (20.8) 31 (0) 36 (0) 36 (8.3)
437 G and A 25 (0) 24 (4.2) 31 (0) 36 (0) 36 (5.6)
A437 (Wt) 25 (96.0) 24 (75.0) 31 (100.0) 36 (100.0) 36 (86.1)
540E 25 (0) 24 (4.2) 31 (0) 36 (0) 36 (0)
540 E and K 25 (4.0) 24 (0) 31 (0) 36 (0) 36 (0)
K540 (Wt) 25 (96.0) 24 (95.8) 31 (100.0) 36 (100.0) 36 (100.0)
437G and 540E 25 (0) 24 (0) 31 (0) 36 (0) 36 (0)

*Pfcrt, P. falciparum chloroquine resistance transporter; Pfdhpr, P. falciparum dihydrofolate reductase; Pfdhps, P. falciparum dihydropteroate synthase.

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