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Volume 17, Number 10—October 2011

Research

Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus Infection in England and Scotland, 2009–2010

Laurence CalatayudComments to Author , Angie Lackenby, Arlene Reynolds, Jim McMenamin, Nick F. Phin, Maria Zambon, and Richard Pebody
Author affiliations: Health Protection Agency, London, UK (L. Calatayud, A. Lackenby, N.F. Phin, M.C. Zambon, R. Pebody); Health Protection Scotland, Glasgow, Scotland, UK (A. Reynolds, J. McMenamin)

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Table 3

Distribution of age, sex, underlying medical conditions, and outcomes among persons hospitalized for oseltamivir-sensitive pandemic (H1N1) 2009 and persons hospitalized for the disease but not tested for antiviral susceptibility, England and Scotland, April 27, 2009–April 30, 2010*

Characteristic No. (%) patients with oseltamivir-sensitive strains, n = 346
No. (%) patients not tested for antiviral susceptibility, n = 2,471
χ2 p value
n With characteristic n With characteristic
Sex
M 346 155 (44.8) 2,471 1,176 (47.6) 0.95 0.33
F
346
191 (55.2)

2,471
1295 (52.4)


Age group, y
0–4 346 64 (18.5) 2,471 479 (19.4)
5–14 346 83 (24.0) 2,471 463 (18.7) 2.72 0.099
15–24 346 59 (17.1) 2,471 406 (16.4) 0.19 0.663
25–44 346 74 (21.4) 2,471 611 (24.7) 0.29 0.590
45–64 346 56 (16.2) 2,471 391 (15.8) 0.13 0.718
>65
346
10 (2.9)

2,471
121 (4.9)
1.86
0.173
Any predisposing disease 278 164 (59.0) 1,985 1,315 (66.2) 5.67 0.017
Respiratory 284 94 (33.1) 2,198 652 (29.7) 1.41 0.235
Cardiac 273 12 (4.4) 2,170 107 (4.9) 0.15 0.699
Renal 275 11 (4.0) 2,173 69 (3.2) 0.52 0.469
Liver 272 3 (1.1) 2,170 23 (1.1) 0.004 1.000†
Neurologic 269 15 (5.6) 2,181 135 (6.2) 0.16 0.692
Immunosuppression 275 19 (6.9) 1,980 237 (12.0) 6.14 0.013
Diabetes 276 6 (2.2) 2,173 104 (4.8) 3.89 0.048
Pregnancy 301 19 (6.3) 2,216 171 (7.7) 0.75 0.387
Other chronic disease
258
32 (12.4)

1,836
262 (14.3)
0.65
0.419
Complications 346 76 (22.0) 2,471 392 (15.9) 8.15 0.004
Respiratory 346 67(19.4) 2,471 374 (15.1) 4.11 0.043
Cardiac 346 2 (0.6) 2,471 0 14.29 0.015†
Renal 346 8 (2.3) 2,471 33 (1.3) 2.02 0.155
Liver 346 1 (0.3) 2,471 0 7.14 0.123†
Neurologic 346 5 (1.4) 2,471 2 (0.08) 22.78 <0.001†
Otitis 346 0 2,471 1 (0.04) 0.14 1.000†
Other
346
12 (3.5)

2,471
22 (0.9)
16.91
<0.001
ICU admission 205 59 (28.8) 1,542 258 (16.7) 17.69 <0.001
Death 322 18 (5.6) 2,253 78 (3.5) 3.55 0.059

*n indicates no. patients with information available for that category. ICU, intensive care unit.
†By Fisher exact test.

*n indicates no. patients with information available for that category. ICU, intensive care unit.
†By Fisher exact test.

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