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Volume 17, Number 12—December 2011
Research

Candidate Cell Substrates, Vaccine Production, and Transmissible Spongiform Encephalopathies

Pedro PiccardoComments to Author , Larisa Cervenakova, Irina Vasilyeva, Oksana Yakovleva, Igor Bacik, Juraj Cervenak, Carroll McKenzie, Lubica Kurillova, Luisa Gregori, Kitty Pomeroy, and David M. Asher
Author affiliations: University of Edinburgh, Easter Bush, UK, (P. Piccardo); Food and Drug Administration, Kensington, Maryland, USA (P. Piccardo, I. Bacik, J. Cervenak, L. Kurillova, L. Gregori, K. Pomeroy, D.M. Asher); Holland Laboratory American Red Cross, Rockville, Maryland, USA (L. Cervenakova, I. Vasilyeva, O. Yakovleva, C. McKenzie)

Main Article

Table 1

Cell cultures exposed to transmissible spongiform encephalopathy agents and propagated for 30 passages*

Variable sCJD vCJD BSE 22L-scrapie
Actual or candidate cell lines for vaccine production
CHO-K1 Y Y Y
Vero C1008 Y Y Y
WI-38 Y Y Y
MDCK Y Y Y
HEK-293 Y Y Y
Other cells resistant to TSE infection
MBDK Y
EBTR Y
BT Y
BCE C/D-1b Y
BL3.1 Y
R9ab Y Y Y
Cells infectable with 22L scrapie
Mo3F4-3T3 Y
L929 Y

*sCJD, sporadic Creutzfeldt-Jakob disease; vCJD, variant Creutzfeldt-Jakob disease; BSE, bovine spongiform encephalopathy; CHO-KI, Chinese hamster ovary; Vero C1008, African green monkey kidney; WI-38, human lung diploid fibroblasts; MDCK, dog kidney; HEK-293, human embryonic kidney; MBDK, bovine kidney; EBTR, bovine trachea; BT, bovine turbinate; BCE C/D-1b, bovine cornea; BL3.1, bovine B lymphocytes; R9ab, rabbit fibroblasts; Mo3F4-3T3, mouse embryo fibroblasts; L929, mouse embryo fibroblasts; Y, experiment was completed.

Main Article

Page created: November 30, 2011
Page updated: November 30, 2011
Page reviewed: November 30, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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