Volume 17, Number 12—December 2011
Dispatch
Novel Sylvatic Rabies Virus Variant in Endangered Golden Palm Civet, Sri Lanka
Takashi Matsumoto, Kamruddin Ahmed
, Omala Wimalaratne, Susilakanthi Nanayakkara, Devika Perera, Dushantha Karunanayake, and Akira Nishizono
, Omala Wimalaratne, Susilakanthi Nanayakkara, Devika Perera, Dushantha Karunanayake, and Akira NishizonoTable 2
Substitutions in genome sequence of rabies virus strain H-1413-09 from Sri Lanka, compared with genome sequence of strain H-08-1320*
| Protein, amino acid substitution | Site/domain/region of protein† |
|---|---|
| N | |
| Leu80 → Phe80 | |
| Glu110 → Asp110 | |
| Ile246 → Val246 | |
| Ala372 → Val372 |
Antigenic site I |
| P | |
| Gln167 → Arg167 |
N protein binding site in variable domain II |
| M | |
| Ile16 → Ala16 | |
| Pro19 → Ser19 | |
| Ile55 → Val55 | |
| Lys77 → Arg77 |
|
| G | |
| Val193 → Ile193 | |
| Arg264 → His264 | |
| Ile449 → Thr449 | Transmembrane region |
| Thr459 → Ile459 | Transmembrane region |
| Ala467 → Thr467 | Cytoplasmic domain |
| Glu475 → Gly457 | Cytoplasmic domain |
| Asn499 → Ser499 |
Cytoplasmic domain |
| L | |
| Ser26 → Pro26 | |
| Ile49 → Leu49 | |
| Cys137 → Tyr137 | |
| Leu222 → Ile222 | |
| Ser312 → Gln312 | Conserved domain I |
| Glu313 → Lys313 | Conserved domain I |
| Ser314 → Ala314 | Conserved domain I |
| Arg315 → Glu315 | Conserved domain I |
| Val317 → Phe317 | Conserved domain I |
| Lys1056 → Arg1056 | Conserved domain IV |
| Thr1137 → Val1137 | Conserved domain V |
| Ala1520 → Glu1520 | |
| Ile1555 → Val1555 | |
| Leu1570 → Met1570 | |
| Met1577 → Leu1577 | |
| Lys1625 → Arg1625 | |
| Asn1763 → Asp1763 | |
| Arg1876 → His1876 | |
| Asn2023 → Asp1763 | |
| Gly2098 → Arg2098 | |
| Leu2113 → Phe2113 |
*H-08-1320 is a human strain typical of canine rabies virus circulating in Sri Lanka; H-1413-09 is a novel sylvatic rabies virus variant from a golden palm civet in Sri Lanka.
†Blank spaces indicate no site/domain/region has been identified in that portion of the protein.
