Volume 17, Number 7—July 2011
Neurognathostomiasis, a Neglected Parasitosis of the Central Nervous System
| Travel or residence in the disease-endemic area
AND exposure to undercooked freshwater fish, frogs, poultry,
| Painful radiculomyelitis/radiculomyeloencephalitis
OR intracerebral hemorrhage
OR subarachnoid hemorrhage
|Indirect evidence of CNS invasion|
| CSF studies: eosinophilic pleocytosis
OR neuroimaging: parenchymal hemorrhagic tracks (>3 mm)
|Positive detection of reactivity against the 24-kDa component of Gnathostoma spinigerum in immunoblot test†|
|Absence of reactivity against the 29–31-kDa components of Angiostrongylus cantonensis in immunoblot test|
*All criteria should be fullfiled for clinical diagnosis of neurognathostomiasis. CNS, central nervous system; CSF, cerebrospinal fluid.
†If negative, a follow-up examination 4 weeks later is recommended.