Emerging Infectious Disease ISSN: 1080-6059

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Candida spp. with Acquired Echinocandin Resistance, France, 2004–2010¹

Eric Dannaoui², Marie Desnos-Ollivier², Dea Garcia-Hermoso, Fredéric Grenouillet, Sophie Cassaing, Marie-Thérèse Baixench, Stéphane Bretagne, Françoise Dromer, Olivier Lortholary

, and the French Mycoses Study Group

Author affiliations: Institut Pasteur, Paris, France (E. Dannaoui, M. Desnos-Ollivier, D. Garcia-Hermoso, S. Bretagne, F. Dromer, O. Lortholary); Centre Hospitalier Universitaire de Besançon, Besançon France (F. Grenouillet); Centre Hospitalier Universitaire de Toulouse–Hôpital Rangueil, Toulouse, France (S. Cassaing); Hôpital Cochin, Paris (M.-T. Baixench)

Main Article

Table 2

In vitro susceptibility and Fksp mutations of 20 echinocandin-resistant Candida spp. isolates, France, 2004–2010

Patient no.	Strain	Species	MIC, µg/m, AM3/RPMI 1640 medium			Fksp mutation
Patient no.	Strain	Species	Caspofungin	Micafungin	Anidulafungin	Gene	Mutation
1*	05BL1-38	C. albicans	1/2	0.25/1	0.06/0.125	FKS1 (HS1)	F641S
2*	ODL13-1254	C. albicans	1/2	1/1	0.5/0.5	FKS1 (HS1)	S645Y
3†	06BL2-127	C. albicans	2/2	1/0.5	0.125/0.125	FKS1 (HS1)	F641S‡ + S645P‡
4	ODL19-1894	C. albicans	4/2	2/2	0.125/0.25	FKS1 (HS1)	S645P
5*	08BL1-94	C. albicans	2/4	0.25/1	0.06/0.5	FKS1 (HS2)	R1361G§
6*	08BL2-143	C. albicans	8/4	4/2	0.25/0.5	FKS1 (HS1)	S645P
7*	09BL1-43	C. albicans	1/2	0.25/1	0.06/0.25	FKS1 (HS1)	F641S
8*	09BL1-77	C. albicans	0.5/0.5	0.5/0.25	0.015/0.03	FKS1 (HS1)	R647G§
9	06BL1-34	C. krusei	4/8	2/4	1/2	FKS1 (HS1)	L648W§,¶
10*	10BL1-50	C. krusei	2/4	1/2	0.06/1	FKS1 (HS1)	F645L§,¶
11	ODL7-647	C. glabrata	8/8	0.5/1	0.25/0.125	FKS2	DelF658#
12*	07BL2-157	C. glabrata	4/1	1/0.5	0.25/0.5	FKS2	DelF658#
13*	06BL1-33	C. glabrata	8/8	4/8	2/2	FKS2	S663P
14*	ODL21-2028	C. glabrata	1/1	0.25/0.25	0.25/0.25	FKS1	S629P
15*	ODL22-2183	C. glabrata	8/2	0.25/0.25	0.25/1	FKS2	S663P
16	ODL23-2221	C. glabrata	1/4	0.06/2	0.06/0.25	FKS1 + FKS2	F625I§ (FKS1) + P667T§ (FKS2)
17*	08BL2-142	C. glabrata	1/4	0.25/2	0.25/2	FKS2	S663P
18	09BL1-55	C. glabrata	8/4	2/4	0.5/0.5	FKS2	S663P
19	10BL1-19	C. glabrata	0.5/4	0.06/0.5	0.06/1	FKS2	F659S + L664V§
20	10BL1-67	C. glabrata	4/4	0.5/1	0.125/1	FKS2	DelF658#

*Parentage of initial isolate available.
†In this patient, another isolate with reduced susceptibility to echinocandin was retrieved. This isolate harbored an S645P mutation in FKS1.
‡Heterozygous mutation.
§Mutations not already described (13).
¶Strains had also an L701M mutation.
#Deletion.

Main Article

¹This work was presented in part at the 20th European Congress of Clinical Microbiology and Infectious Diseases, Vienna, Austria, April 10–13, 2010 (abstract no. O346).

²These authors contributed equally to this article.

³Additional members of the French Mycoses Study Group who contributed data are listed at the end of this article.

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