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Volume 18, Number 1—January 2012

Research

High Prevalence of Multidrug-Resistant Tuberculosis, Swaziland, 2009–2010

Elisabeth Sanchez-PadillaComments to Author , Themba Dlamini, Alexandra Ascorra, Sabine Rüsch-Gerdes, Zerihun Demissie Tefera, Philippe Calain, Roberto de la Tour, Frauke Jochims, Elvira Richter, and Maryline Bonnet
Author affiliations: Epicentre, Paris, France (E. Sanchez-Padilla, A. Ascorra, M. Bonnet); National Tuberculosis Control Programme, Mbabane, Swaziland (T. Dlamini); National Reference Center for Mycobacteria, Borstel, Germany (S. Rüsch-Gerdes, E. Richter); Médecins Sans Frontières, Geneva, Switzerland (Z.D. Tefera, P. Calain, R. de la Tour, F. Jochims)

Main Article

Table 2

Patterns of first-line drug resistance in new and previously treated case-patients with TB, Swaziland 2009–2010*

Resistance pattern New, n = 352
Previously treated, n = 281
No. (%) 95% CI No. (%) 95% CI
Susceptible to all first-line drugs 298 (84.7) 80.9–88.4 142 (50.5) 44.7–56.4
Any resistance 54 (15.3) 11.6–19.1 139 (49.5) 43.6–55.3
Isoniazid 47 (13.4) 9.8–16.9 127 (45.2) 39.4–51.0
Rifampin 28 (8.0) 5.1–10.8 102 (36.3) 30.7–41.9
Ethambutol 29 (8.2) 5.4–11.1 94 (33.5) 27.9–39.0
Streptomycin 47 (13.4) 9.8–16.9 115 (40.9) 35.2–46.7
Monoresistance 12 (3.4) 1.5–5.3 24 (8.6) 5.3–11.8
Isoniazid 5 (1.4) 0.2–2.7 12 (4.3) 1.9–6.6
Rifampin 1 (0.3) 0.0–0.8 7 (2.5) 0.7–4.3
Ethambutol 0 0
Streptomycin 6 (1.7) 0.4–3.1 5 (1.8) 0.2–3.3
MDR 27 (7.7) 4.9–10.5 95 (33.8) 28.3–39.3
Isoniazid + rifampin 1 (0.3) 0.0–0.8 3 (1.1) 0.0–2.3
Isoniazid + rifampin + ethambutol 0 2 (0.7) 0.0–1.7
Isoniazid + rifampin + streptomycin 6 (1.7) 0.4–3.1 12 (4.3) 1.9–6.6
Isoniazid + rifampin + streptomycin + ethambutol 20 (5.7) 3.3–8.1 78 (27.8) 22.5–33.0
Other first-line drug-resistance patterns different from MDR 15 (4.3) 2.2–6.4 20 (7.1) 4.1–10.1
Isoniazid + streptomycin 6 (1.7) 0.4–3.1 6 (2.1) 0.4–3.8
Isoniazid + streptomycin + ethambutol 9 (2.6) 0.9–4.2 14 (5.0) 2.4–7.5

*New case-patients were those not previously treated for TB or who had taken anti-TB drugs in the past for <1 month. TB, tuberculosis; MDR, multidrug resistant.

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