Volume 18, Number 1—January 2012
Research
Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009
Shamez N. Ladhani
, Jay Lucidarme, Lynne S. Newbold, Stephen J. Gray, Anthony D. Carr, Jamie Findlow, Mary E. Ramsay, Edward B. Kaczmarski, and Raymond Borrow
, Jay Lucidarme, Lynne S. Newbold, Stephen J. Gray, Anthony D. Carr, Jamie Findlow, Mary E. Ramsay, Edward B. Kaczmarski, and Raymond Borrow
Table A1
Molecular analysis of 114 MenY isolates causing invasive disease, England and Wales, 2007–2009*
| Clonal complex | Sequence type | fhbp | nhba | FetA | PorA | lpxL1 mutation |
|---|---|---|---|---|---|---|
| 23 (64)† | 1655 (30) | 2.25 (30) | P0007 (30) | 4-1 (30) | P1.5-1,10-1,36-2 (18) | XVI (18) |
| P1.5-1,10-4,36-2 (6) | XVI (6) | |||||
| P1.5-1,10-10,36-2 (3) | XVI (3) | |||||
| P1.5-1,10-1,25 (2) | XVI (2) | |||||
| P1.5-1,10-12,36-2 (1) | XVI (1) | |||||
| 23 (22) | 2.25 (20) | P0006 (5) | 5-8 (5) | P1.5-1,2-2,36-2 (5) | XV (3) | |
| IV (1) | ||||||
| V (1) | ||||||
| P0007 (7) | 4-1 (7) | P1.5-1,10-4,36-2 (4) | XVI (3) | |||
| V (1) | ||||||
| P1.5-2,10-1,25 (1) | V (1) | |||||
| P1.5-2,10-1,36-2 (2) | V (1) | |||||
| VI (1) | ||||||
| P0008 (8) | 5-8 (7) | P1.5-1,2-2,36-2 (5) | V (5) | |||
| P1.5-1,2-2,25 (1) | V (1) | |||||
| NP (1) | V (1) | |||||
| 1-7 (1) | P1.5-1,2-2,36-2 (1) | V (1) | ||||
| 2.104 (1) | P0008 (1) | 2-13 (1) | P1.5-2,10-2,104 (1) | I (1) | ||
| 3.300 (1) | P0007 (1) | 4-1 (1) | P1.5-2,10-1,36-2 (1) | V (1) | ||
| 183 (2) | 2.104 (2) | P0008 (2) | NP (1) | P1.5-2,10-2,36-2 (1) | Intact (1) | |
| 4-1 (1) | P1.5-2,10-2,36-2 (1) | V (1) | ||||
| 8411 (2) | 2.25 (2) | P0006 (2) | 5-8 (2) | P1.5-1,2-2,36-2 (2) | XV (2) | |
| Other (7) | 2.25 (4) | P0007 (3) | 4-1 (3) | P1.5-1,10-4,36-2 (1) | V (1) | |
| P1.5-1,10-4,36-2 (1) | XVI (1) | |||||
| P1.5-2,10-1,36-2 (1) | V (1) | |||||
| P0008 (1) | 5-8 (1) | P1.5-1,2-2,36-2 (1) | V (1) | |||
| 2.104 (1) | P0008 (1) | 2-13 (1) | P1.5-2,10-2,36-2 (1) | XVII (1) | ||
| 3.293 (1) | P0007 (1) | 4-1 (1) | P1.5-2,10-1,36-2 (1) | V (1) | ||
| 1.335 (1) | P0008 (1) | 4-1 (1) | P1.18-1,25,38-1 (1) | Intact (1) | ||
| NK (1) | 3.293 (1) | P0007 (1) | 4-1 (1) | P1.5-2,10-1,36-2 (1) | V (1) | |
| 174 (24) | 1466 (20) | 2.21 (18) | P0006 (17) | 3-7 (16) | P1.21,16,37-1 (10) | Intact (10) |
| P1.21,16,21 (1) | Intact (1) | |||||
| P1.22,9,35-1 (2) | Intact (2) | |||||
| P1.5-1,10-8,36-2 (2) | Intact (1) | |||||
| NK (1) | ||||||
| P1.7,30,38 (1) | Intact (1) | |||||
| 2-16 (1) | P1.5-1,2-2,36-2 (1) | Intact (1) | ||||
| P0242 (1) | 3-7 (1) | P1.22,9,35-1 (1) | Intact (1) | |||
| 1.13 (1) | P0006 (1) | 3-7 (1) | P1.21,16,37-1 (1) | Intact (1) | ||
| 1.258 (1) | P0006 (1) | 3-7 (1) | P1.21,16,37-1 (1) | Intact (1) | ||
| 7850 (2) | 2.21 (2) | P0006 (2) | 3-7 (2) | P1.21,16,21 (1) | Intact (1) | |
| P1.21,16,37-1 (1) | Intact (1) | |||||
| 8413 (1) | 2.21 (1) | P0006 (1) | 3-7 (1) | P1.22,9,35-1 (1) | Intact (1) | |
| 7263 (1) | 2.21 (1) | P0006 (1) | 3-7 (1) | P1.21,16,37-1 (1) | Intact (1) | |
| 167 (12) | 1627 (4) | 2.23 (4) | P0009 (4) | 3-6 (4) | P1.5-1,10-4,36-2 (2) | Intact (2) |
| P1.5-1,10-8,36-2 (1) | Intact (1) | |||||
| P1.5-1,10-1,36-2 (1) | Intact (1) | |||||
| 168 (3) | 2.19 (2) | P0009 (2) | 3-1 (1) | P1.5-1,10-4,36-2 (1) | Intact (1) | |
| 5-2 (1) | P1.5-1,10-4,36-2 (1) | Intact (1) | ||||
| 2.23 (1) | P0009 (1) | 4-1 (1) | P1.5-1,10-8,36-2 (1) | Intact (1) | ||
| 1624 (3) | 2.23 (3) | P0009 (3) | 3-4 (3) | P1.5-1,10-4,36-2 (3) | Intact (3) | |
| 7921 (1) | 2.16 (1) | P0009 (1) | 3-6 (1) | P1.5-1,10-4,36-2 (1) | Intact (1) | |
| 8420 (1) | 2.23 (1) | P0009 (1) | 1-3 (1) | P1.5-1,10-1,36-2 (1) | Intact (1) | |
| 22 (9) | 3651 (3) | 2.25 (3) | P0020 (3) | 5-1 (3) | P1.5-1,2-2,36-2 (2) | Intact (2) |
| P1.5,2-2,36-2 (1) | Intact (1) | |||||
| 114 (2) | 2.16 (2) | P0020 (2) | 5-1 (2) | P1.5-1,10-22,36-2 (2) | Intact (2) | |
| 184 (1) | 2.16 (1) | P0020 (1) | 3-9 (1) | P1.18-1,3,38 (1) | Intact (1) | |
| 1221 (1) | 2.25 (1) | P0020 (1) | 1-7 (1) | P1.18-1,3,38 (1) | Intact (1) | |
| 2180 (1) | 2.25 (1) | P0020 (1) | 1-2 (1) | P1.18-1,3,38 (1) | Intact (1) | |
| 2878 (1) | 2.16 (1) | P0020 (1) | 4-1 (1) | P1.18-1,3,38 (1) | Intact (1) | |
| Unassigned (3) | 3015 (2) | 2.16 (2) | P0020 (2) | 3-4 (1) | P1.18-1,3,38 (1) | Intact (1) |
| 5-8 (1) | P1.5-2,10-1,36-2 (1) | Intact (1) | ||||
| 7786 (1) | 2.16 (1) | P0020 (1) | 3-4 (1) | NP (1) | Intact (1) | |
| 92 (1) | 5418 (1) | 2.21 (1) | P0009 (1) | 4-1 (1) | P1.5-1,10-22,36-2 (1) | Intact (1) |
| 103 (1) | 103 (1) | 2.25 (1) | P0024 (1) | 3-9 (1) | P1.5-1,10-46,36-2 (1) | Intact (1) |
*MenY, meningococcal capsular group Y; fhbp , factor H binding protein (Novartis variant family.peptide); nhba, neisserial heparin-binding antigen; fetA, ferric enterochelin receptor variable region; porA, PorA variable regions (P1.VR1,VR2,VR3); lpxL1, acyl-transferase gene; NK, not known; NP, no product. Numbers in parentheses are the number of isolates.
†The sequence type for 1 clonal complex 23 strain was not available because of failure of existing primers to amplify the glucose-6-phosphate dehydrogenase (gdh) locus, but the remaining 6 loci were successfully characterized and were sufficient to assign the isolate to clonal complex 23.
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