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Volume 18, Number 10—October 2012

Research

WU and KI Polyomaviruses in Respiratory Samples from Allogeneic Hematopoietic Cell Transplant Recipients

Jane Kuypers1Comments to Author , Angela P. Campbell1, Katherine A. Guthrie, Nancy L. Wright, Janet A. Englund, Lawrence Corey, and Michael Boeckh
Author affiliations: University of Washington, Seattle, Washington, USA (J. Kuypers, A.P. Campbell, N.L. Wright, J.A. Englund, L. Corey, M. Boeckh); Fred Hutchinson Cancer Research Center, Seattle (J. Kuypers, A.P. Campbell, K.A. Guthrie, J.A. Englund, L. Corey, M. Boeckh); and Seattle Children’s Hospital, Seattle (A.P. Campbell, J.A. Englund)

Main Article

Table 3

Respiratory and systemic symptoms associated with KIPyV or WUPyV detection within the prior week or month in HCT recipients*

Symptom KIPyV†
WUPyV†
OR (95% CI) p value OR (95% CI) p value
Within prior week

Runny nose

1.3 (0.7–2.4) 0.39 1.2 (0.5–3.2) 0.66

Sinus congestion

0.8 (0.5–1.3) 0.34 1.4 (0.6–3.5) 0.46

Postnasal drip

0.8 (0.4–1.8) 0.65 1.2 (0.5–3.0) 0.72

Shortness of breath

0.9 (0.4–1.8) 0.73 0.9 (0.3–2.9) 0.83

Sputum production

1.7 (1.0–2.9) 0.04 1.5 (0.5–4.8) 0.47

Pharyngitis

1.0 (0.6–1.7) 0.99 2.1 (0.8–5.4) 0.12

Sneezing

1.2 (0.7–2.0) 0.54 1.3 (0.6–2.9) 0.48

Watery eyes

1.5 (0.8–2.6) 0.17 1.6 (0.4–6.2) 0.51

Cough

1.1 (0.6–2.0) 0.68 1.4 (0.6–3.5) 0.47

Wheezing

1.1 (0.5–2.5) 0.82 2.1 (0.8–5.9) 0.15

Fever

0.9 (0.5–1.5) 0.59 1.3 (0.4–3.7) 0.64

Headache

0.6 (0.4–1.1) 0.08 0.7 (0.2–2.8) 0.58

Myalgia

0.6 (0.3–1.1) 0.08 1.1 (0.3–3.5) 0.92

Diarrhea

0.8 (0.5–1.3) 0.40 0.7 (0.3–1.8) 0.47
Within prior month

Cough

1.0 (0.6–1.8) 0.91 1.6 (0.7–3.5) 0.26

Wheezing

1.0 (0.5–2.2) 0.99 3.1 (1.2–8.1) 0.02

*Values are for 211 of 222 patients with symptom survey data. Ear pain was too rare for analysis. KIPyV, KI polyomavirus; WUPyV, WU polyomavirus; HCT, hematopoietic cell transplantation; OR, odds ratio.
†Each result was adjusted for the following covariates: detection of the other polyomavirus (KIPyV or WUPyV), detection of a respiratory virus, day relative to transplantation, age at transplantation, stem cell source, donor type, and grades 2–4 acute graft-versus-host-disease.

Main Article

1These authors contributed equally to this article.

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