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Volume 18, Number 2—February 2012
Research

Pathogenesis of Avian Bornavirus in Experimentally Infected Cockatiels

Anne K. PiepenbringComments to Author , Dirk Enderlein, Sibylle Herzog, Erhard F. Kaleta, Ursula Heffels-Redmann, Saskia Ressmeyer, Christiane Herden, and Michael Lierz
Author affiliations: Justus Liebig University Giessen, Giessen, Germany

Main Article

Table 1

Premortem findings in cockatiels experimentally infected with ABV*

Bird Age at inoculation,d/sex Antibodies against ABV
 RNA‡, first detected, dpi Gastrointestinal signs
 Neurologic signs
 Died, dpi Euthanized, dpi
First detected, dpi Titer† First detected, dpi Titer† First detected, dpi Titer†
ic1 137/F 43 160 27 – – 199 5,120 – 206
ic2 121/F 29 20 21 37 320 41 320 – 60
ic3 137/F 35 320 25 – – – – – 115
ic4 137/F 7 20 19 – – – – – 115
ic5 121/F 57 320 29 – – – – – 230
ic6 137/M 43 1,280 25 – – – – 66 –
ic7 137/M 63 160 29 – – – – – 230
ic8 137/F 43 640 27 – – – – – 115
ic9 44/M 7 10 25 – – – – – 230
iv1 137/F 57 320 71 126 5,120 – – – 229
iv2 137/F 35 160 35 – – – 120 –
iv3 137/M 57 640 43 116 10,240 – – – 116
iv4 137/M 29 40 63 – – – – – 116
iv5 121/F 35 640 72 – – 159 5,120 – 229
iv6 121/F 43 640 33 – – – – – 229
iv7 137/M 35 40 35 – – – – – 116
iv8 137/M 35 40 43 – – – – – 229
iv9 44/F 29 40 25 – – – – – 229
se1 137/M NA – 76 – – – – – 230

*Investigation period was 230 d. ABV, avian bornavirus; dpi, days postinoculation; ic, intracerebrally inoculated; –, not detected or not applicable; iv, intravenously inoculated; se, sentinel.
†Antibodies detected by use of indirect immunofluorescence assay; titers <10.0 are considered negative.
‡Avian bornavirus RNA detected by real-time reverse transcription PCR as described by Honkavuori et al. (10); cycle thresholds >36.0 are negative.

Main Article

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Page created: January 17, 2012
Page updated: January 17, 2012
Page reviewed: January 17, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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