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Volume 18, Number 2—February 2012

Research

Pathogenesis of Avian Bornavirus in Experimentally Infected Cockatiels

Anne K. PiepenbringComments to Author , Dirk Enderlein, Sibylle Herzog, Erhard F. Kaleta, Ursula Heffels-Redmann, Saskia Ressmeyer, Christiane Herden, and Michael Lierz
Author affiliations: Justus Liebig University Giessen, Giessen, Germany

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Table 1

Premortem findings in cockatiels experimentally infected with ABV*

Bird Age at inoculation,d/sex Antibodies against ABV
RNA‡, first detected, dpi Gastrointestinal signs
Neurologic signs
Died, dpi Euthanized, dpi
First detected, dpi Titer† First detected, dpi Titer† First detected, dpi Titer†
ic1 137/F 43 160 27 199 5,120 206
ic2 121/F 29 20 21 37 320 41 320 60
ic3 137/F 35 320 25 115
ic4 137/F 7 20 19 115
ic5 121/F 57 320 29 230
ic6 137/M 43 1,280 25 66
ic7 137/M 63 160 29 230
ic8 137/F 43 640 27 115
ic9 44/M 7 10 25 230
iv1 137/F 57 320 71 126 5,120 229
iv2 137/F 35 160 35 120
iv3 137/M 57 640 43 116 10,240 116
iv4 137/M 29 40 63 116
iv5 121/F 35 640 72 159 5,120 229
iv6 121/F 43 640 33 229
iv7 137/M 35 40 35 116
iv8 137/M 35 40 43 229
iv9 44/F 29 40 25 229
se1 137/M NA 76 230

*Investigation period was 230 d. ABV, avian bornavirus; dpi, days postinoculation; ic, intracerebrally inoculated; –, not detected or not applicable; iv, intravenously inoculated; se, sentinel.
†Antibodies detected by use of indirect immunofluorescence assay; titers <10.0 are considered negative.
‡Avian bornavirus RNA detected by real-time reverse transcription PCR as described by Honkavuori et al. (10); cycle thresholds >36.0 are negative.

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