Volume 18, Number 3—March 2012
Research
Lineage-specific Virulence Determinants of Haemophilus influenzae Biogroup aegyptius
Fiona R. Strouts1, Peter Power, Nicholas J. Croucher, Nicola Corton, Andries van Tonder, Michael A. Quail, Paul R. Langford, Michael J. Hudson, Julian Parkhill, J. Simon Kroll
, and Stephen D. Bentley
, and Stephen D. BentleyTable 4
Coding sequences specific to Haemophilus influenzae biogroup aegyptius strain F3031 at 10 loci*
| Locus no. and F3031 ID | G+C, % | % Identity | Predicted product | Species harboring closest homologue |
|---|---|---|---|---|
| 1, phage region 1† | ||||
| HIBPF00881 | 41.2 | 60 | Conserved hypothetical protein | Neisseria meningitidis |
| HIBPF00900 | 37.6 | 68 | Plasmid maintenance system killer | Haemophilus parasuis |
| HIBPF00910 | 40.2 | 82 | Plasmid maintenance system antidote protein | Neisseria gonorrhoeae |
| HIBPF01110 | 40.2 | 70 | Conserved hypothetical protein | H. parasuis |
| HIBPF01260 |
38.5 |
NA |
Unknown protein, no known homologs |
NA |
| 2, phage region 3† | ||||
| HIBPF04833 | 40.1 | NA | Unknown protein, no known homologs | NA |
| HIBPF04834 |
37.6 |
54 |
Conserved hypothetical protein |
H. parasuis |
| 3 | ||||
| HIBPF05360 |
27.5 |
NA |
Unknown protein, no known homologs |
NA |
| 4, phage region 4† | ||||
| HIBPF09220 | 41.2 | 55 | Conserved hypothetical protein | Haemophilus haemolyticus |
| HIBPF09642 | 31.2 | NA | Unknown protein, no known homologs | NA |
| HIBPF09722 |
31.9 |
80 |
Conserved hypothetical protein |
H. parasuis |
| 5, phage region 5† | ||||
| HIBPF13250 |
44.1 |
75 |
Conserved hypothetical protein |
H. parasuis |
| 6 | ||||
| HIBPF16620 | 37.5 | 65 | Adenine-specific methyltransferase (pseudo) | Mannheimia haemolytica |
| HIBPF16630 |
38.1 |
71 |
HNH endonuclease |
M. haemolytica |
| 7 | ||||
| HIBPF17711 | 32.6 | 53 | Conserved hypothetical protein | Escherichia coli |
| HIBPF17712 |
26.5 |
49 |
Conserved hypothetical protein |
N. meningitidis |
| 8 | ||||
| HIBPF18000 | 28.1 | 52 | DNA methyltransferase | Macrococcus caseolyticus |
| HIBPF18010 | 26.7 | 56 | DNA methyltransferase | M. caseolyticus |
| HIBPF18040 |
30.3 |
44 |
Restriction endonuclease |
M. caseolyticus |
| 9 | ||||
| HIBPF19140 | 35.3 | 100 | HadA trimeric autotransporter adhesin | Previously identified in HaeBPF |
| HIBPF20030 | 36.1 | 77 | Antibiotic biosynthesis monooxygenase | Aggregatibacter aphrophilus |
*Putative product based on closest homologue in public databases, shown by percent amino acid identity. Percentage G+C content given for each coding sequence. ID, identification; NA, not applicable.
†Genes occur within regions of bacteriophage.
1Current affiliation: Stanford University, Palo Alto, California, USA.
