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Volume 18, Number 3—March 2012

Research

Lineage-specific Virulence Determinants of Haemophilus influenzae Biogroup aegyptius

Fiona R. Strouts1, Peter Power, Nicholas J. Croucher, Nicola Corton, Andries van Tonder, Michael A. Quail, Paul R. Langford, Michael J. Hudson, Julian Parkhill, J. Simon KrollComments to Author , and Stephen D. Bentley
Author affiliations: Imperial College London, London, UK (F.R. Strouts, P.R. Langford, J.S. Kroll); University of Oxford, Oxford, UK (P. Power); Wellcome Trust Sanger Institute, Cambridge, UK (N.J. Croucher, N. Corton, A. van Tonder, M.A. Quail, J. Parkhill, S.D. Bentley); The Health Protection Agency, Salisbury, UK (M.J. Hudson)

Main Article

Table 4

Coding sequences specific to Haemophilus influenzae biogroup aegyptius strain F3031 at 10 loci*

Locus no. and F3031 ID G+C, % % Identity Predicted product Species harboring closest homologue
1, phage region 1†
HIBPF00881 41.2 60 Conserved hypothetical protein Neisseria meningitidis
HIBPF00900 37.6 68 Plasmid maintenance system killer Haemophilus parasuis
HIBPF00910 40.2 82 Plasmid maintenance system antidote protein Neisseria gonorrhoeae
HIBPF01110 40.2 70 Conserved hypothetical protein H. parasuis
HIBPF01260
38.5
NA
Unknown protein, no known homologs
NA
2, phage region 3†
HIBPF04833 40.1 NA Unknown protein, no known homologs NA
HIBPF04834
37.6
54
Conserved hypothetical protein
H. parasuis
3
HIBPF05360
27.5
NA
Unknown protein, no known homologs
NA
4, phage region 4†
HIBPF09220 41.2 55 Conserved hypothetical protein Haemophilus haemolyticus
HIBPF09642 31.2 NA Unknown protein, no known homologs NA
HIBPF09722
31.9
80
Conserved hypothetical protein
H. parasuis
5, phage region 5†
HIBPF13250
44.1
75
Conserved hypothetical protein
H. parasuis
6
HIBPF16620 37.5 65 Adenine-specific methyltransferase (pseudo) Mannheimia haemolytica
HIBPF16630
38.1
71
HNH endonuclease
M. haemolytica
7
HIBPF17711 32.6 53 Conserved hypothetical protein Escherichia coli
HIBPF17712
26.5
49
Conserved hypothetical protein
N. meningitidis
8
HIBPF18000 28.1 52 DNA methyltransferase Macrococcus caseolyticus
HIBPF18010 26.7 56 DNA methyltransferase M. caseolyticus
HIBPF18040
30.3
44
Restriction endonuclease
M. caseolyticus
9
HIBPF19140 35.3 100 HadA trimeric autotransporter adhesin Previously identified in HaeBPF
HIBPF20030 36.1 77 Antibiotic biosynthesis monooxygenase Aggregatibacter aphrophilus

*Putative product based on closest homologue in public databases, shown by percent amino acid identity. Percentage G+C content given for each coding sequence. ID, identification; NA, not applicable.
†Genes occur within regions of bacteriophage.

Main Article

1Current affiliation: Stanford University, Palo Alto, California, USA.

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