Mycobacterial Lineages Causing Pulmonary and Extrapulmonary Tuberculosis, Ethiopia
Rebuma Firdessa12, Stefan Berg1, Elena Hailu1, Esther Schelling, Balako Gumi, Girume Erenso, Endalamaw Gadisa, Teklu Kiros, Meseret Habtamu, Jemal Hussein, Jakob Zinsstag, Brian D. Robertson, Gobena Ameni, Amanda J. Lohan, Brendan Loftus, Iñaki Comas, Sebastien Gagneux, Rea Tschopp, Lawrence Yamuah, Glyn Hewinson, Stephen V. Gordon, Douglas B. Young, and Abraham Aseffa
Author affiliations: Author affiliations: Armauer Hansen Research Institute, Addis Ababa, Ethiopia (R. Firdessa, E. Hailu, B. Gumi, G. Erenso, E. Gadisa, T. Kiros, M. Habtamu, J. Hussein, R. Tschopp, L. Yamuah, A. Aseffa); Animal Health and Veterinary Laboratories Agency, Weybridge, UK (S. Berg, G. Hewinson); Swiss Tropical and Public Health Institute, Basel, Switzerland (E. Schelling, J. Zinsstag, S. Gagneux, R. Tschopp); University of Basel, Basel (E. Schelling, J. Zinsstag, S. Gagneux); Imperial College, London, London, UK (B.D. Robertson, D.B. Young); Addis Ababa University, Addis Ababa (G. Ameni); University College Dublin Conway Institute, Dublin, Ireland (A.J. Lohan, B. Loftus, S.V. Gordon); National Institute for Medical Research, London (I. Comas, D.B. Young); Centre for Public Health Research, Valencia, Spain (I. Comas); Centro de Investigación y Educación en Red en Epidemiología Biomédica Pública, Madrid, Spain (I. Comas)
Figure 1. . . Lineages of the Mycobacterium tuberculosis (MTB) complex, Ethiopia, 2006–2010. Genome sequence analysis of 4 strains representative of 36 related isolates identified them as members of a new phylogenetic lineage (lineage 7) of M. tuberculosis, which has a phylogenetic location intermediate between ancient lineage 1 and modern Lineages 2, 3, and 4, and a branch point before the deletion of the TbD1 region (3). Nomenclatures for lineage names and numbers are as proposed (4,6). Phylogeny shown is based on 13,199 nt positions that were variable in at least 1 of the 28 M. tuberculosis complex strains represented in the tree. Numbers near nodes indicate percentage of bootstrap replicates supporting the topology after 1,000 pseudoreplicates. MAF, M. africanum; MBO, M. bovis.
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