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Volume 19, Number 3—March 2013

Research

Effects of Vaccine Program against Pandemic Influenza A(H1N1) Virus, United States, 2009–2010

Rebekah H. Borse1, Sundar S. Shrestha, Anthony E. Fiore, Charisma Y. Atkins, James A. Singleton, Carolyn Furlow, and Martin I. MeltzerComments to Author 
Author affiliations: Author affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table 9

Results of sensitivity analyses to determine the impact of the effectiveness of the first dose of vaccine against influenza A(H1N1)pdm09 virus among children 6 months–9 years of age*

Outcome prevented Base estimate: 62% vaccine effectiveness 2 wk after dose 2† Sensitivity estimate (range)
20% Vaccine effectiveness 2 wk after dose 1 and 62% effectiveness 2 wk after dose 2‡ 40% Vaccine effectiveness 2 wk after dose 1 and 62% effectiveness 2 wk after dose 2§
Clinical cases 81,518 (52,081–100,349) 212,363 (152,420–268,852) 347,323 (256,510–439,714)
Hospitalizations 614 (328–1,090) 1,473 (906–2,294) 2,393 (1,520–3,964)
Deaths 9 (5–15) 21 (13–35) 33 (21–55)

*Data reflect calculations made for scenario 7 by estimating changes in assumed effectiveness first dose of vaccine among children 6 months–9 years of age.
†1 dose achieves 0% effectiveness against clinical cases, hospitalizations, and deaths; 2nd dose 4 wk later is 62% effective against hospitalizations and deaths 2 weeks after administration.
‡1 dose achieves 20% effectiveness against clinical cases, hospitalizations, and deaths after 2 wk; 2nd dose 4 wk later achieves 62% against hospitalizations and deaths 2 weeks after administration.
§1 dose achieves 40% effectiveness against clinical cases, hospitalizations, and deaths after 2 wk; 2nd dose 4 wk later achieves 62% against hospitalizations and deaths 2 weeks after administration.

Main Article

1Current affiliation: Merck & Co., Inc., Lansdale, Pennsylvania, USA.

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