Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human Betacoronavirus
Matthew Cotten, Tommy T. Lam, Simon J. Watson, Anne L. Palser, Velislava Petrova, Paul Grant, Oliver G. Pybus, Andrew Rambaut, Yi Guan, Deenan Pillay, Paul Kellam , and Eleni Nastouli
Author affiliations: Wellcome Trust Sanger Institute, Hinxton, UK (M. Cotten, S.J. Watson, A.L. Palser, V. Petrova, P. Kellam); University of Oxford, Oxford, UK (T.T. Lam, O.G. Pybus); University College London, London, UK (D. Pillay, P. Kellam); University College London Hospitals,; London (P.Grant, E. Nastouli); University of Edinburgh, Edinburgh, Scotland, UK (A. Rambaut); Fogarty International Center–National Institutes for Health, Bethesda, Maryland, USA (A. Rambaut); The University of Hong Kong, Hong Kong (Y. Guan)
Figure 4. . . . tMRCA analysis across a range of fixed evolutionary rates. The tMRCA of EMC/2012 and England/Qatar/2012 estimated from fixing a range of genomic evolutionary rates (1 × 10−4, 2 × 10−4, 5 × 10−4, 1 × 10−3, 2 × 10−3, and 5 × 10−3 substitutions/site/year) are shown in data points with vertical error bars (95% highest posterior density). Evolutionary rate estimates of human CoV genome and genes in the literature are indicated at the bottom of the plot (mean or point estimate as a dot, 95% CIs of estimate as a square bracket). tMRCA, time to the most recent common ancestor; CoV, coronavirus; SARS, severe acute respiratory syndrome; ORF, open reading frame.
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