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Volume 19, Number 7—July 2013

Research

Mutation in Spike Protein Cleavage Site and Pathogenesis of Feline Coronavirus

Beth N. Licitra1, Jean K. Millet1, Andrew D. Regan, Brian S. Hamilton, Vera D. Rinaldi, Gerald E. Duhamel, and Gary R. WhittakerComments to Author 
Author affiliations: Cornell University College of Veterinary Medicine, Ithaca, New York, USA

Main Article

Table 1

Status of cats sampled for feline coronavirus and mutations in spike protein cleavage site*

FECV-infected cats FIPV-infected cats Total
Cats harboring viruses with >1 mutated S1/S2 site 2 10 12
Cats harboring viruses with an intact S1/S2 site 28 1 29
Total 30 11 41

FECV, feline enteric coronavirus; FIPV, feline infectious peritonitis; S1, receptor-binding domain of spike; S2, fusion domain of spike.

Main Article

1These authors contributed equally to this article.

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