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Volume 23, Number 2—February 2017
Research

Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity

Hongbo Guo1, Erik de Vries1, Ryan McBride, Jojanneke Dekkers, Wenjie Peng, Kim M. Bouwman, Corwin Nycholat, M. Helene Verheije, James C. Paulson, Frank J.M. van Kuppeveld, and Cornelis A.M. de HaanComments to Author 
Author affiliations: Utrecht University, Utrecht, the Netherlands (H. Guo, E. de Vries, J. Dekkers, K.M. Bouwman, M.H. Verheije, F.J.M. van Kuppeveld, C.A.M. de Haan); The Scripps Research Institute, La Jolla, California, USA (R. McBride, W. Peng, C. Nycholat, J.C. Paulson)

Main Article

Figure 3

Glycan structures of influenza A viruses. Structures are shown for sialylated glycans present in the array in nonfucosylated (glycans 1–9) and fucosylated (glycans 11–19) forms and binding by hemagglutinins is shown in Figures 2 and 7. Glycans 1 and 11 correspond to 3′SLN (nonfucosylated glycan) and 3′SLeX (fucosylated form of 3′SLN), respectively. Similarly, glycans 3 and 13 correspond to 6-O-sulfo 3′SLN (6S-3′SLN) and 6-O-sulfo 3′SLeX (6S-3′SLeX), respectively. Blue squares, N-acetylglucosamin

Figure 3. Glycan structures of influenza A viruses. Structures are shown for sialylated glycans present in the array in nonfucosylated (glycans 1–9) and fucosylated (glycans 11–19) forms and binding by hemagglutinins is shown in Figures 2 and 7. Glycans 1 and 11 correspond to 3′SLN (nonfucosylated glycan) and 3′SLeX (fucosylated form of 3′SLN), respectively. Similarly, glycans 3 and 13 correspond to 6-O-sulfo 3′SLN (6S-3′SLN) and 6-O-sulfo 3′SLeX (6S-3′SLeX), respectively. Blue squares, N-acetylglucosamine; yellow circles, galactose; green circles, mannose; purple diamonds, sialic acid; red triangles, fucose. H5N12.3.4, novel H5N1 virus clade 2.3.4.

Main Article

1These authors contributed equally to this article.

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