Volume 23, Number 2—February 2017
Research
Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity
Hongbo Guo1, Erik de Vries1, Ryan McBride, Jojanneke Dekkers, Wenjie Peng, Kim M. Bouwman, Corwin Nycholat, M. Helene Verheije, James C. Paulson, Frank J.M. van Kuppeveld, and Cornelis A.M. de Haan
Table 1
Amino acids in hemagglutinins from 2,562 highly pathogenic influenza A(H5N1) viruses isolated during 1996−2015 (excluding clade 2.3.4.4 viruses)
| Position and amino acid | No. occurrences |
|---|---|
| 18K | 119 |
| 49N | 301 |
| 57K | 481 |
| 76K | 16 |
| 76R | 0 |
| 86R | 5 |
| 98T | 32 |
| 99L | 57 |
| 118T | 1 |
| 119L | 0 |
| 123R | 40 |
| 127P | 329 |
| 128N | 276 |
| 131T | 49 |
| 133L | 1,029 |
| 137A | 545 |
| 144A | 4 |
| 145S | 1,873 |
| 160A | 1,467 |
| 166I | 160 |
| 173R | 67 |
| 187N | 117 |
| 193N | 4 |
| 196K | 183 |
| 199D | 0 |
| 202V | 75 |
| 222Q | 2 |
| 227R | 23 |
| 244H | 316 |
| 267T | 1,805 |
| 273M | 10 |
| 277H | 1 |
| 494K | 0 |
| 500I | 0 |
1These authors contributed equally to this article.
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