Volume 8, Number 12—December 2002
Research
Efficacy of Killed Virus Vaccine, Live Attenuated Chimeric Virus Vaccine, and Passive Immunization for Prevention of West Nile virus Encephalitis in Hamster Model
Robert B. Tesh*
, Juan Arroyo†, Amelia P.A. Travassos da Rosa*, Hilda Guzman*, Shu-Yuan Xiao*, and Thomas P. Monath†
, Juan Arroyo†, Amelia P.A. Travassos da Rosa*, Hilda Guzman*, Shu-Yuan Xiao*, and Thomas P. Monath†Table 3
Level and duration of viremia in hamsters previously immunized with WNV killed virus vaccine (Fort Dodge) and challenged with the NY385-99 strain of WNVa
| Animal no. | Postinfection, by day |
|||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | |
| 8440 | 0b | 0 | 0 | 0 | 0 | 0 |
| 8441 | 0 | 1.2 | 3.5 | 1.3 | 1.2 | 0 |
| 8442 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8443 | 0 | 0 | 0 | 0 | 0 | 0 |
| 9445 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8446 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8447 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8448 | 0 | 0.7 | 3.0 | 4.3 | 2.3 | 0 |
| 8449 | 0 | 0 | 0 | 0 | 0 | 0 |
aWNV, West Nile virus.
bVirus titers in blood expressed as log10 50% tissue culture infective dose50/mL of blood. 0 = <100.7 TCID50.
