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Volume 8, Number 12—December 2002

Research

Efficacy of Killed Virus Vaccine, Live Attenuated Chimeric Virus Vaccine, and Passive Immunization for Prevention of West Nile virus Encephalitis in Hamster Model

Robert B. Tesh*Comments to Author , Juan Arroyo†, Amelia P.A. Travassos da Rosa*, Hilda Guzman*, Shu-Yuan Xiao*, and Thomas P. Monath†
Author affiliations: *University of Texas Medical Branch, Galveston, Texas, USA; †Acambis, Inc., Cambridge, Massachusetts, USA;

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Table 3

Level and duration of viremia in hamsters previously immunized with WNV killed virus vaccine (Fort Dodge) and challenged with the NY385-99 strain of WNVa

Animal no. Postinfection, by day
1 2 3 4 5 6
8440 0b 0 0 0 0 0
8441 0 1.2 3.5 1.3 1.2 0
8442 0 0 0 0 0 0
8443 0 0 0 0 0 0
9445 0 0 0 0 0 0
8446 0 0 0 0 0 0
8447 0 0 0 0 0 0
8448 0 0.7 3.0 4.3 2.3 0
8449 0 0 0 0 0 0

aWNV, West Nile virus.
bVirus titers in blood expressed as log10 50% tissue culture infective dose50/mL of blood. 0 = <100.7 TCID50.

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