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Volume 17, Number 9—September 2011

Research

Classical Bovine Spongiform Encephalopathy by Transmission of H-Type Prion in Homologous Prion Protein Context

Juan-María TorresComments to Author , Olivier Andréoletti, Caroline Lacroux, Irene Prieto, Patricia Lorenzo, Magdalena Larska, Thierry Baron, and Juan-Carlos Espinosa
Author affiliations: Author affiliations: Centro de Investigación en Sanidad Animal, Madrid, Spain (J.-M. Torres, I. Prieto, P. Lorenzo, M. Larska, J.-C. Espinosa); Ecole Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti, C. Lacroux); Agence Francaise de Sécurité Sanitaire des Aliments, Lyon, France (T. Baron)

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Figure 5

Comparison of the amount of protease-resistant prion protein (PrPres) in brain sample from mouse inoculated with BSE-H (isolate 02-2695) showing either high-type (lane 1 and 2, first and second passages, respectively) or classical BSE–like PrPres molecular profile (lanes 3 and 4, first and second passages, respectively). Identical amounts of 10% brain homogenate were loaded in each lane. Western blot was shown with Sha31 monoclonal antibody. Values to the left indicate molecular mass in kDa. BSE

Figure 5. Comparison of the amount of protease-resistant prion protein (PrPres) in brain sample from mouse inoculated with BSE-H (isolate 02-2695) showing either high-type (lane 1 and 2, first and second passages, respectively) or classical BSE–like PrPres molecular profile (lanes 3 and 4, first and second passages, respectively). Identical amounts of 10% brain homogenate were loaded in each lane. Western blot was shown with Sha31 monoclonal antibody. Values to the left indicate molecular mass in kDa. BSE, bovine spongiform encephalopathy; BSE-H, unglycosylated PrPres that is higher than classical BSE–like.

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