Volume 17, Number 9—September 2011
Estimating Effect of Antiviral Drug Use during Pandemic (H1N1) 2009 Outbreak, United States
From April 2009 through March 2010, during the pandemic (H1N1) 2009 outbreak, ≈8.2 million prescriptions for influenza neuraminidase-inhibiting antiviral drugs were filled in the United States. We estimated the number of hospitalizations likely averted due to use of these antiviral medications. After adjusting for prescriptions that were used for prophylaxis and personal stockpiles, as well as for patients who did not complete their drug regimen, we estimated the filled prescriptions prevented ≈8,400–12,600 hospitalizations (on the basis of median values). Approximately 60% of these prevented hospitalizations were among adults 18–64 years of age, with the remainder almost equally divided between children 0–17 years of age and adults >65 years of age. Public health officials should consider these estimates an indication of success of treating patients during the 2009 pandemic and a warning of the need for renewed planning to cope with the next pandemic.
From April 23, 2009, through April 10, 2010, it is estimated that pandemic (H1N1) 2009 virus caused ≈61 million cases of influenza (range 43–89 million cases), ≈270,000 related hospitalizations (range 195,000–403,000 hospitalizations), and ≈12,500 deaths (range 8,900–18,300 deaths) in the United States (1). Even before the impact was fully known, the Centers for Disease Control and Prevention (CDC) recommended prompt empiric treatment with influenza antiviral drugs, principally the neuraminidase-inhibiting influenza antiviral drugs oseltamivir and zanamivir, of persons with suspected or confirmed influenza and who also met >1 of the following conditions: 1) illness that required hospitalization; 2) progressive, severe, or complicated illness, regardless of previous health status; and 3) risk for severe disease (e.g., patients with asthma, neurologic and neurodevelopmental conditions; chronic lung or heart disease; blood, endocrine, kidney, liver, and metabolic disorders; pregnancy; and those who were old or young) (2). The primary goal of these recommendations was to reduce the number and severity of pandemic (H1N1) 2009 cases, especially hospitalizations.
We present estimates of the number of pandemic (H1N1) 2009–related hospitalizations, by age group, averted because of use of antiviral drugs given to treat clinical cases of influenza. These results can be used by public health policy makers to plan and prepare for the next pandemic. For example, these estimates can be used to help evaluate the policy option of replenishing state and federal influenza antiviral drug stockpiles
We developed a spreadsheet-based model to calculate the number of pandemic (H1N1) 2009–related hospitalizations averted because of treatment with the neuraminidase-inhibiting influenza antiviral drugs oseltamivir and zanamivir (Technical Appendix). The risk for hospitalization (and thus potential benefit from antiviral drugs) differed by age groups (1). Therefore, we estimated the reduced number of hospitalizations separately for 3 groups: persons 0–17 years of age, 18–64 years of age, and >65 years of age. We calculated the hospitalizations averted by using the following general equation: no. hospitalizations averted (by age group) = [no. prescriptions written – estimated no. written for prophylaxis, stockpiling, or incomplete adherence to drug regimen] × age group–specific risk for hospitalizations caused by pandemic (H1N1) 2009 × age group–specific effectiveness of drugs in preventing hospitalizations.
We used the number of prescriptions filled for these drugs for weeks ending April 24, 2009, through March 26, 2010 (Table 1), collected from the IMS Health (IMS) Xponent proprietary prescription database (IMS Health, Norwalk, CT, USA) (3). This database contains all retail prescriptions filled from a representative sample of 35,000 (73%) of ≈50,000 US-based retail pharmacies, including independent pharmacies, chain pharmacies, pharmacies in discount outlets, pharmacies in food stores, mail order pharmacies, and pharmacy benefit management companies. IMS then proportionately extrapolates their data on the basis of populations served by the included pharmacies to provide weekly estimates of all prescriptions filled in the United States for these drugs. The Xponent database does not track prescriptions filled by in-hospital pharmacies. Therefore, in-hospital prescriptions are not part of our calculations.
The IMS Xponent database captures all filled prescriptions related to influenza antiviral drugs within its sample pharmacies. However, it does not identify the source of the drugs. During 2009, there were 2 main potential supplies for the antiviral drugs—the regular commercial supply system and state and federal government-maintained drug stockpiles. The IMS database does not track medications dispensed from public domains, such as public health departments. Furthermore, the federal and state stockpiles of antiviral drugs were meant to supplement the commercial supply chain in times of drug shortages anticipated to occur during a pandemic emergency.
As of August 2010, the estimated total amount of antiviral drugs managed by states throughout the pandemic was 38 million treatment regimens. This estimate includes antiviral drugs purchased by states (26 million treatment regimens) plus ≈12 million treatment regimens distributed early in the pandemic to states from the CDC Strategic National Stockpile (SNS). Preliminary reports from state public health departments to the CDC show that most SNS product was either retained by the health departments or deployed at the local level (to dispensing sites such as drug stores and health departments). Sites received directions that the SNS-provided supplies were to be dispensed if commercial supplies could not keep up with demand or used to treat uninsured or underinsured persons who could otherwise not afford treatment. Preliminary data reported to CDC through SNS show that minimum quantities of stockpiled antiviral drugs were actually dispensed to patients. Because the commercial supply chain for antiviral drugs remained relatively robust, most states did not need to use stockpiled antiviral drugs. Therefore, we did not include any estimates of impact on antiviral drugs dispensed from these government stockpiles.
Prescriptions by Age Group
IMS collects for filled prescriptions deidentified data regarding age of patient from the pharmacy systems. We thus divided the total number of prescriptions given into 3 age groups (0–17 years, 18–64 years, >65 years) by using age-specific data from IMS that covered prescriptions written for oseltamivir from October 9, 2009, through March 26, 2010. The percentages were as follows: 0–17 years, 38.6%; 18–64 years, 53.4%; >65 years, 5.3% (Table 2). Note that ≈3% of prescriptions filled during this period did not have the age of the patient recorded. Therefore, we did not include those prescriptions in our analysis.
Prescriptions over Time
We plotted the total number of prescriptions filled per week, from the IMS database, against the weekly number of estimated pandemic cases for April 24, 2009, through March 26, 2010. Estimates of cases for April through the end of July 2009 are not available on a weekly basis. Thus, all cases were combined into a single estimate for that period (1). We combined for the same period all filled prescriptions and directly compared cases and prescriptions. A notable divergence in the correlation between plots of cases and prescriptions over time would indicate the possibility of prescriptions being filled for reasons other than the immediate treatment of influenza-related illness (e.g., stockpiling or use for prophylaxis).
Percentage of Prescriptions Written for Prophylaxis
We assumed in the absence of any data that 10% of all prescriptions for these antiviral drugs were written for prophylaxis. This assumption was subject to sensitivity analyses (described below). We further assumed that such prescriptions essentially had no impact on reduction of hospitalizations (Table 2).
Adherence to Drug Regimen and Stockpiling
We also assumed that a total of 20% of all prescriptions were for either personal stockpiles (i.e., not written for a clinically ill patient at time of prescription) or patients who did not sufficiently follow the recommended drug regimen so that the prescription had no impact on risk of hospitalization caused by nonadherence (Table 2). A study conducted in the United Kingdom during the (H1N1) 2009 pandemic found that 76%–80% of the patients did complete the full course of prescribed antiviral drugs (5). Another study among schoolchildren in London, UK, that examined adherence among those offered oseltamivir for prophylaxis found that 89% actually took >1 dose and 66% of this group completed (or said they would complete) a full 10-day prophylaxis course (6). One of the drug effectiveness studies that we reviewed (discussed below) and used for model input values asked patients to self-record adherence; it found that ≈90% of enrolled patients were fully compliant (7). Our assumption that 20% of prescriptions were for either stockpiling or nonadherence was subject to sensitivity analyses (described below).
This allowance for nonadherence also acts as a proxy for those who may have started the treatment too late. To maximize drug effectiveness in alleviating the duration of symptoms, it is recommended that antiviral drug treatment start <48 hours after onset of clinical symptoms (2).
Risk for Hospitalization Given Clinical Case of Pandemic (H1N1) 2009
We used the risk for hospitalization by age group, given clinical illness caused by pandemic (H1N1) 2009, from Reed et al. (4) (Table 2). We identified 17 published studies that evaluated the effectiveness of neuraminidase inhibitors given influenza-induced clinical illness (7,8–21; Table 3). Although many studies were random placebo-controlled trials, the studies did not use hospitalizations averted as a measured endpoint (13,15–17). We identified only 4 studies that specifically evaluated the impact of the antiviral drugs on risk for hospitalization, given clinical illness. One study provided an estimate of 50% reduction in the probability of influenza-specific hospitalizations (no confidence interval was published) (7). Three retrospective studies, using health insurance claims data, reported effectiveness in reducing hospitalizations (any cause) that ranged from 22% to 59%, with some variation by age (8–10). For each age group, we used lower and upper estimates of effectiveness, from a lower estimate of 22% reduction for children 0–17 years to an upper estimate of 50% for adults (Table 2).
Calculating Ranges and Sensitivity Analyses
For each level of antiviral effectiveness (lower, upper), and for each age group, we calculated the median and lower and upper estimates of hospitalizations averted. We also conducted sensitivity analyses by altering from 0% to 30% the assumed percentages of prescriptions written for prophylaxis, personal stockpiles, and patients who did not adhere to the drug regimen.
Pandemic influenza vaccine became available in week 40 of 2009 (near the peak of cases). We hypothesized that before this date is when doctors would have been most likely to try to protect patients by prescribing prophylactic courses of antiviral drugs. However, the plot of the prescription data against estimated cases over time shows a close correlation between the occurrence of pandemic (H1N1) 2009 clinical cases and filled prescriptions (Table 1; Figure). This comparison suggests that antiviral drugs were mostly prescribed to treat the occurrence of clinical cases of pandemic (H1N1) 2009.
The total number of prescriptions filled before adjustments was 8.2 million (Table 1). After removing the prescriptions presumed filled for prophylaxis and for patients who failed to adhere to the drug regimen or had prescriptions filled for personal stockpiles, 5.7 million prescriptions were filled that may have reduced hospitalizations (Table 4). Most (97%) were filled for oseltamivir, and ≈55% of all prescriptions filled were for persons 18–64 years of age, and ≈40% were filled for children 0–17 years of age.
We estimated that the median number of hospitalizations averted ranged from 8,427 (lower 6,961; upper 9,479) to 12,641 (lower 10,442; upper 14,219) (Table 5). Approximately 60% of averted hospitalizations were among persons 18–64 years old. The estimated hospitalizations averted in children and adults >65 years of age (Table 5) were similar. Although adults >65 years of age received only ≈5% of filled prescriptions (Table 4), these prescriptions had a relatively substantial impact in averting hospitalizations because the risk for hospitalization is higher in this age group than the other risk groups (Table 2).
Doubling the assumed percentages of filled prescriptions for prophylaxis and personal stockpiles/nonadherence from 30% to 60% (i.e., a 100% increase) produced only a 40% reduction in median hospitalizations averted, from ≈12,600 to 7,200 (Table 6). Thus, the major factors influencing hospitalizations averted were total prescriptions filled and (assumed) effectiveness of the drugs in preventing hospitalizations.
The close correlation between estimated pandemic influenza cases and filled prescriptions (Figure) can be used as evidence that antiviral drugs were mostly used to treat those who were clinically ill (i.e., recommendations regarding use were essentially followed). Restricting the use of antiviral drugs to treating the clinically ill meant that preventing clinical cases from deteriorating into severe cases requiring hospitalizations was likely to have been among the major effects of antiviral drug use. By our estimates, this strategy worked; ≈8,000–13,000 hospitalizations were averted (Table 5). This reduction is equivalent to ≈4–5% of the total estimated pandemic (H1N1) 2009–related hospitalizations (1).
We found no other studies with which to compare our methods and results. We compared the accuracy of the IMS database using unpublished data from the Behavioral Risk Factor Surveillance System (BRFSS), conducted in 49 states (excluding Vermont, the District of Columbia, and Puerto Rico). From September 1, 2009, through March 31, 2010, adults (>18 years old) responding to the BRFSS telephone survey were asked whether they had influenza-like illness (ILI) (defined as having had a fever with cough or sore throat) in the month preceding the interview. They were also asked if they sought medical care for their ILI condition and if they were prescribed antiviral drugs to treat their illnesses. Extrapolating the results to the national level in the period covered by the survey, we found that ≈54 million adults reported having ILI symptoms. Of those who reported having ILI and sought medical care, 4.1 million adults reported they were prescribed influenza antiviral drugs (oseltamivir or zanamivir) during August 2009–March 2010. The IMS database recorded 6.86 million prescriptions in the same period (Table 1); ≈40% for those 0–17 years of age (Table 2), leaving ≈4.1 million filled prescriptions for adults. This estimate is close to the number recorded by the BRFSS survey and further supports the idea that few prescriptions were for prophylaxis or personal stockpiles.
There are many limitations to this study; the biggest is the uncertainty regarding the effectiveness of the drugs in preventing hospitalizations. The effectiveness of the drugs in reducing risk for hospitalization caused by pandemic (H1N1) 2009 may vary considerably from estimates reported for nonpandemic strains of influenza virus. The data are also limited in that we cannot verify if those persons who filled a prescription were actually clinically ill from pandemic (H1N1) 2009 or to what extent they adhered to the drug regimen. We addressed this issue by allowing a wide range in drug effectiveness and a relatively large percentage of prescriptions filled for conditions other than direct treatment of pandemic (H1N1) 2009.
We were unable, because the available literature did not contain sufficiently reliable estimates of effectiveness of antiviral drugs against death, to estimate the number of deaths averted by treatment with antiviral drugs. Shrestha et al. (1) estimated that deaths caused by pandemic (H1N1) 2009 were equivalent to 1.5% of children’s hospitalizations and 6% of hospitalizations for persons of all other ages. Assuming that hospitalizations averted generate similar percentages of deaths averted, then the use of antiviral drugs prevented 27–40 deaths in children 0–17 years of age and 395–597 deaths in adults of all ages (using median values of hospitalizations averted; Table 4).
If during the next pandemic there is a desire to produce better quality estimates (perhaps even produce estimates at regular intervals during the event), then additional data collection systems must be developed to overcome some of these limitations. For example, measuring the number of prescriptions filled for prophylaxis or personal stockpiles or degree of adherence can only reliably be conducted by interviewing patients and physicians. Improving estimates of impact of filled prescriptions in reducing adverse health outcomes during an event will require a large case–control study. Policy makers will have to determine if the value of such information warrants the investment in such data collection systems.
Our results also highlight how the use of influenza antiviral drugs during a pandemic is likely to be beneficial, notably through a presumed reduction in the demand for hospital-based resources. Reduced demand will also reduce costs of hospitalizations. Assuming a cost per influenza-related hospitalization of US$5,000–$7,000 per patient admitted (adjusted to 2009 dollars) (22–26), averted hospitalizations saved ≈$42 million to $88 million (based on median values of hospitalizations averted; Table 4). A detailed cost-effectiveness analysis, including an in-depth consideration of the costs of hospitalizing pandemic (H1N1) 2009 patients, is the subject of a separate analysis.
If the next influenza pandemic causes greater numbers of severe cases and hospitalizations than in 2009, there may be an increased demand for antiviral drugs for treatment and prophylaxis. Such increased demand could overwhelm the existing commercial distribution chains. Therefore, public health officials should consider these estimates as an indication of success of treating patients during the 2009 pandemic and a warning for the need for renewed planning to cope with the next pandemic.
Ms Atkins is a research assistant at the Centers for Disease Control and Prevention. She is assisting with the development and revisions of several tools that will assist state and local public health organizations with pandemic influenza planning needs.
We thank Alicia Fry for her thoughtful and helpful contributions.
- Shrestha SS, Swerdlow DL, Borse RH, Prabhu VS, Finelli L, Atkins CY. Estimating the burden of 2009 pandemic influenza A (H1N1) in the United States (April 2009–April 2010). Clin Infect Dis. 2011;52(Suppl 1):S75–82.
- Centers for Disease Control and Prevention. Updated interim recommendations for the use of antiviral medications in the treatment and prevention of influenza for the 2009–2010 season [cited 2010 Dec 18]. http://www.cdc.gov/H1N1flu/recommendations.htm#d
- Health IMS. Data Assets, IMS Prescription Data [cited 2010 Dec 18]. http://www.imshealth.com/portal/site/imshealth/menuitem.a46c6d4df3db4b3d88f611019418c22a/?vgnextoid=a4284c30aaaa0210VgnVCM100000ed152ca2RCRD&vgnextchannel=bc42650204850210VgnVCM100000ed152ca2RCRD&vgnextfmt=default
- Reed C, Angulo FJ, Swerdlow DL, Lipsitch M, Meltzer MI, Jernigan D. Estimates of the prevalence of pandemic (H1N1) 2009, United States, April–July 2009. Emerg Infect Dis. 2009;15:2004–7.
- Strong M, Burrows J, Stedman E, Redgrave P. Adverse drug effects following oseltamivir mass treatment and prophylaxis in a school outbreak of 2009 pandemic influenza A(H1N1) in June 2009, Sheffield, United Kingdom. Euro Surveill 2010;15:pii:19565.
- Kitching A, Roche A, Balasegaram S, Heathcock R, Maguire H. Oseltamivir adherence and side effects among children in three London schools affected by influenza A(H1N1)v, May 2009—an internet-based cross-sectional survey. Euro Surveill. 2009;14:pii:19287.
- Kaiser L, Wat C, Mills T, Mahoney P, Ward P, Hayden F. Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations. Arch Intern Med. 2003;163:1667–72.
- Blumentals WA, Schulman KL. Impact of oseltamivir on the incidence of secondary complications of influenza in adolescent and adult patients: results from a retrospective population-based study. Curr Med Res Opin. 2007;23:2961–70.
- Gums JG, Pelletier EM, Blumentals WA. Oseltamivir and influenza-related complications, hospitalization and healthcare expenditure in healthy adults and children. Expert Opin Pharmacother. 2008;9:151–61.
- Orzeck EA, Shi N, Blumentals WA. Oseltamivir and the risk of influenza-related complications and hospitalizations in patients with diabetes. Clin Ther. 2007;29:2246–55.
- Peters PH, Moscona A, Schulman KL, Barr CE. Study of the impact of oseltamivir on the risk for pneumonia and other outcomes of influenza, 2000–2005. Medscape J Med. 2008;10:131.
- Mäkelä MJ, Pauksens K, Rostila T, Fleming DM, Man CY, Keene ON. Clinical efficacy and safety of the orally inhaled neuraminidase inhibitor zanamivir in the treatment of influenza: a randomized, double-blind, placebo-controlled European study. J Infect. 2000;40:42–8.
- Hayden FG, Sperber SJ, Belshe RB, Clover RD, Hay AJ, Pyke S. Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine. Antimicrob Agents Chemother. 1991;35:1741–7.
- The MIST. (Management of Influenza in the Southern Hemisphere Trialists) Study Group. Randomised trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections. Lancet. 1998;352:1877–81.
- Aoki FY, Macleod MD, Paggiaro P, Carewicz O, Sawy AE, Wat C. Early administration of oral oseltamivir increases the benefits of influenza treatment. J Antimicrob Chemother. 2003;51:123–9.
- Hayden FG, Osterhaus AD, Treanor JJ, Fleming DM, Aoki FY, Nicholson KG. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. GG167 Influenza Study Group. N Engl J Med. 1997;337:874–80.
- Lalezari J, Campion K, Keene O, Silagy C. Zanamivir for the treatment of influenza A and B infection in high-risk patients: a pooled analysis of randomized controlled trials. Arch Intern Med. 2001;161:212–7.
- Monto AS, Moult AB, Sharp SJ. Effect of zanamivir on duration and resolution of influenza symptoms. Clin Ther. 2000;22:1294–305.
- Nicholson KG, Aoki FY, Osterhaus AD, Trottier S, Carewicz O, Mercier CH. Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group. Lancet. 2000;355:1845–50.
- Treanor JJ, Hayden FG, Vrooman PS, Barbarash R, Bettis R, Riff D. Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study Group. JAMA. 2000;283:1016–24.
- Whitley RJ, Hayden FG, Reisinger KS, Young N, Dutkowski R, Ipe D. Oral oseltamivir treatment of influenza in children. Pediatr Infect Dis J. 2001;20:127–33.
- Prosser LA, Meltzer MI, Fiore A, Epperson S, Bridges CB, Hinrichsen V. Effects of adverse events of the projected population benefits and cost-effectiveness of using live attenuated influenza vaccine in children aged 6 months to 4 years. Arch Pediatr Adolesc Med. 2011;165:112–8.
- Beigi RH, Wiringa AE, Bailey RR, Assi T-M, Lee BY. Economic value of seasonal and pandemic influenza during pregnancy. Clin Infect Dis. 2009;49:1784–92.
- Fairbrother G, Cassedy A, Ortega-Sanchez IR, Szilagyi PG, Edwards KM, Molinari N-A. High costs of infleunza: direct medical costs of influenza disease in young children. Vaccine. 2010;28:4913–9.
- Keren R, Zaoutis TE, Saddlemire S, Luan XQ, Coffin SE. Direct medical costs of influenza-related hospitalizations in children. Pediatrics. 2007;119:227.
- Cox FM, Cobb MM, Chua WQ, McLaughlin TP, Okamoto LJ. Cost of treating influenza in emergency department and hospital settings. Am J Manag Care. 2000;6:205–14.
Suggested citation for this article: Atkins CY, Patel A, Taylor TH Jr, Biggerstaff M, Merlin TL, Dulin SM, et al. Estimating effect of antiviral drug use during pandemic (H1N1) 2009 outbreak, United States. Emerg Infect Dis [serial on the Internet]. 2011 Sep [date cited]. http://dx.doi.org/10.3201/eid1709.110295
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