Volume 18, Number 12—December 2012
Research
Transmission Routes for Nipah Virus from Malaysia and Bangladesh
Bronwyn A. Clayton, Deborah Middleton, Jemma Bergfeld, Jessica Haining, Rachel Arkinstall, Linfa Wang, and Glenn A. Marsh
Table 5
Histopathologic and immunohistochemical findings in major systems of ferrets infected with NiV from Bangladesh or Malaysia*
| System, predominant lesion |
No. animals with lesion/antigen/vasculitis†
|
|
|---|---|---|
| NiV-Bangladesh, n = 8 | NiV-Malaysia, n = 7 | |
| Respiratory | ||
|
Acute rhinitis |
7/5/1 | 6/7/0 |
|
Acute bronchoalveolitis |
8/8/1
|
7/7/4
|
| Lymphoid | ||
|
Lymphadenitis |
8/8/1 | 7/7/0 |
|
Splenic necrosis |
7/7/1
|
6/7/1
|
|
Renal, glomerular necrosis
|
8/6/0
|
6/7/1
|
|
Hepatic, focal hepatic necrosis
|
8/7/0
|
1‡/2/0
|
| Central nervous | ||
|
Meningitis |
0/4/0 | 2/5/1 |
|
Encephalitis |
0/7/0 | 0/3/0 |
*NiV, Nipah virus.
†No. animals in which the predominant lesion was observed/antigen staining was observed in that organ or tissue/vasculitis was present in that organ or tissue. For all animals, vasculitis was associated with antigen staining in blood vessel endothelium or tunica media.
‡This animal also had cholecystitis with associated viral antigen.
