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Volume 19, Number 5—May 2013

Research

Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates

Edgar HolznagelComments to Author , Barbara Yutzy, Walter Schulz-Schaeffer, Carina Kruip, Uwe Hahmann, Pär Bierke, Juan-Maria Torres, Yong-Sun Kim, Achim Thomzig, Michael Beekes, Gerhard Hunsmann, and Johannes Loewer
Author affiliations: Paul-Ehrlich-Institut, Langen, Germany (E. Holznagel, B. Yutzy, C. Kruip, J. Loewer); University of Göttingen, Göttingen, Germany (W. Schulz-Schaeffer); German Primate Centre, Göttingen (U. Hahmann, G. Hunsmann); Swedish Institute for Infectious Disease Control, Solna, Sweden (P. Bierke); Centro de Investigación en Sanidad Animal, Madrid, Spain (J.-M. Torres); Hallym University, Anyang, Gyeonggi-Do, South Korea (Y.-S. Kim); Robert-Koch-Institut, Berlin, Germany (A. Thomzig, M. Beekes)

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Figure 4

Western blot analysis of bovine spongiform encephalopathy proteinease-resistant prion protein (PrPres) (lumbar spinal cord segments) in preclinical and clinically ill macaques. An atypical PrPres pattern was detectable in macaques euthanized during incubation from 3 years p.i. (macaque S11) to 6.5 years p.i. (macaque C1). All samples were co-stained with an anti-actin-antiserum. p.i., postinoculation; PK, proteinase K; mAb, monoclonal antibody.

Figure 4. . Western blot analysis of bovine spongiform encephalopathy proteinease-resistant prion protein (PrPres) (lumbar spinal cord segments) in preclinical and clinically ill macaques. An atypical PrPres pattern was detectable in macaques euthanized during incubation from 3 years p.i. (macaque S11) to 6.5 years p.i. (macaque C1). All samples were co-stained with an anti-actin-antiserum. p.i., postinoculation; PK, proteinase K; mAb, monoclonal antibody.

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