Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates
Edgar Holznagel , Barbara Yutzy, Walter Schulz-Schaeffer, Carina Kruip, Uwe Hahmann, Pär Bierke, Juan-Maria Torres, Yong-Sun Kim, Achim Thomzig, Michael Beekes, Gerhard Hunsmann, and Johannes Loewer
Author affiliations: Paul-Ehrlich-Institut, Langen, Germany (E. Holznagel, B. Yutzy, C. Kruip, J. Loewer); University of Göttingen, Göttingen, Germany (W. Schulz-Schaeffer); German Primate Centre, Göttingen (U. Hahmann, G. Hunsmann); Swedish Institute for Infectious Disease Control, Solna, Sweden (P. Bierke); Centro de Investigación en Sanidad Animal, Madrid, Spain (J.-M. Torres); Hallym University, Anyang, Gyeonggi-Do, South Korea (Y.-S. Kim); Robert-Koch-Institut, Berlin, Germany (A. Thomzig, M. Beekes)
Figure 4. . Western blot analysis of bovine spongiform encephalopathy proteinease-resistant prion protein (PrPres) (lumbar spinal cord segments) in preclinical and clinically ill macaques. An atypical PrPres pattern was detectable in macaques euthanized during incubation from 3 years p.i. (macaque S11) to 6.5 years p.i. (macaque C1). All samples were co-stained with an anti-actin-antiserum. p.i., postinoculation; PK, proteinase K; mAb, monoclonal antibody.
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.