Volume 19, Number 5—May 2013
Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates
|Macaque||Sex||BSE dose, g||Euthanized, y postinoculation||14-3-3p–positive CSF||PrPres pattern (brain)||PrPres pattern (spinal cord C1–T12)||PrPres pattern (spinal cord L1–L4)|
|Group I (clinically infected)†|
|Group II (preclinical)§|
|Group III (preclinical)¶|
|Group IV (controls)#|
*BSE, bovine spongiform encephalopathy; PrPres, proteinase-resistant prion protein; CSF, cerebrospinal fluid; C, cervical; T, thoracic; L, lumbar; neg, negative.
†Received 1 BSE dose, observed until onset of clinical signs.
‡Macaque S6 had a highly stimulated immune system on the day of oral exposure and thereafter (reason unknown) and had the highest postmortem levels of proteinease-resistant prion protein (PrPres) in spleen and other lymphoreticular tissues of all examined macaques (data not shown).
§Animals received 1 BSE dose and were euthanized at regular intervals during incubation period (all animals had PrPres -positive non–central nervous system tissue).
¶Cumulative BSE dose, euthanized.
#Exposed to mock (non–BSE-infected) bovine brain material and euthanized during aging to act as age-matched controls.