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Volume 19, Number 9—September 2013

Research

Use of Staged Molecular Analysis to Determine Causes of Unexplained Central Nervous System Infections

Chien-Chin HsuComments to Author , Rafal Tokarz, Thomas Briese, Hung-Chin Tsai, Phenix-Lan Quan, and W. Ian Lipkin
Author affiliations: Columbia University, New York, New York, USA (C.-C. Hsu, R. Tokarz, T. Briese, P.-L. Quan, W.I. Lipkin); Southern Taiwan University of Science and Technology, Tainan, Taiwan (C.-C. Hsu); Chi-Mei Medical Center, Tainan (C.-C. Hsu); National Yang-Ming University Kaohsiung, Taiwan (H.-C. Tsai); Kaohsiung Veterans General Hospital, Kaohsiung (H.-C. Tsai)

Main Article

Table 4

EBV antibody in CSF and serum of patients identified with EBV infections by MassTag PCR*

Case CSF
Serum
VCA IgM VCA IgG EBV EA EBV NA VCA IgM VCA IgG EBV EA EBV NA
1 + +
2 + +
3 ND ND ND ND
4 + ND ND ND ND
5 + + + ND ND ND ND
6 + + +
7 + + +
8 + ND ND ND ND
9 + ND ND ND ND
10 + + +
11 + +
12 + + +
13 + ND ND ND ND
14 + ND ND ND ND
15 + ND ND ND ND
16 + +

*EBV antibody was measured by using commercial kit Euroimmun (Medizinische Labordiagnostika, Lübeck, Germany). Results were evaluated semiquantitatively by calculating a ratio of the extinction value of the control or patient samples over the extinction value of calibrator. Ratio <0.8: negative; ratio >1.1: positive. EBV, Epstein-Barr virus; CSF, cerebrospinal fluid; VCA, viral capsid antigen; EBV NA, EBV nuclear antigen indicating past EBV infections; EBV EA, EBV early antigen, indicating current or recent EBV infection; –, negative; +, positive; ND, not done.

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