Emerging Infectious Disease ISSN: 1080-6059

A Mathematical Model and CD4+ Lymphocyte Dynamics in HIV Infection

Tomáš Hraba* and Jaroslav Dolezal†

Author affiliations: *Institute of Molecular Genetics, Prague, Czech Republic; †Honeywell Technology Center, Prague, and Institute of Information Theory and Automation, Prague, Czech Republic

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Figure 4

Simulated effect of temporary AZT treatment ( = 0.005) started 5 years after the acquisition of HIV infection and lasted 1, 2, or 3 years—curves 1, 2, and 3, respectively. *CD4+ cell observed values are depicted as circles and those of CD8+ lymphocytes as squares. Both simulated and observed values are depicted as a percentage of normal CD4+ lymphocyte numbers (the normal value of CD8+ lymphocytes is thus 66.7%).

Figure 4. Simulated effect of temporary AZT treatment ( = 0.005) started 5 years after the acquisition of HIV infection and lasted 1, 2, or 3 years—curves 1, 2, and 3, respectively. *CD4+ cell observed values are depicted as circles and those of CD8+ lymphocytes as squares. Both simulated and observed values are depicted as a percentage of normal CD4+ lymphocyte numbers (the normal value of CD8+ lymphocytes is thus 66.7%).

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