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Volume 19, Number 12—December 2013

Research

Spontaneous Generation of Infectious Prion Disease in Transgenic Mice

Juan-María TorresComments to Author , Joaquín Castilla, Belén Pintado, Alfonso Gutiérrez-Adan, Olivier Andréoletti, Patricia Aguilar-Calvo, Ana-Isabel Arroba, Beatriz Parra-Arrondo, Isidro Ferrer, Jorge Manzanares, and Juan-Carlos Espinosa
Author affiliations: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, Spain (J.-M. Torres, J. Castilla, B. Pintado, A. Gutiérrez-Adán P. Aguilar-Calvo, A.-I. Arroba, B. Parra-Arrondo, J.-C. Espinosa); Basque Foundation for Science, Bilbao, Spain (J. Castilla); Ecole Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti); Hospitalet de Llobregat, Barcelona, Spain (I. Ferrer); Universidad Miguel Hernandez, Sant Joan d´Alacant, Spain (J. Manzanares)

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Figure 5

Immunochemical analysis of paraffin-embedded tissue blots of representative coronal sections of the hippocampus, showing deposition patterns of abnormal isoform of host-encoded prion protein in brains from BoPrP-Tg110 mice infected with bovine spongiform encephalopathy (BSE)-C (A), 113L-BSE (B), BSE-H (C), and BSE-L (D) prions. BoPrP, bovine prion protein; 113L, leucine substitution at codon 113. Monoclonal antibody Sha31 stained by using the procedure of Andréoletti et al. (29). Original magnif

Figure 5. . . Immunochemical analysis of paraffin-embedded tissue blots of representative coronal sections of the hippocampus, showing deposition patterns of abnormal isoform of host-encoded prion protein in brains from BoPrP-Tg110 mice infected with bovine spongiform encephalopathy (BSE)-C (A), 113L-BSE (B), BSE-H (C), and BSE-L (D) prions. BoPrP, bovine prion protein; 113L, leucine substitution at codon 113. Monoclonal antibody Sha31 stained by using the procedure of Andréoletti et al. (29). Original magnifications ×20.

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