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Volume 19, Number 12—December 2013

Research

Spontaneous Generation of Infectious Prion Disease in Transgenic Mice

Juan-María TorresComments to Author , Joaquín Castilla, Belén Pintado, Alfonso Gutiérrez-Adan, Olivier Andréoletti, Patricia Aguilar-Calvo, Ana-Isabel Arroba, Beatriz Parra-Arrondo, Isidro Ferrer, Jorge Manzanares, and Juan-Carlos Espinosa
Author affiliations: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid, Spain (J.-M. Torres, J. Castilla, B. Pintado, A. Gutiérrez-Adán P. Aguilar-Calvo, A.-I. Arroba, B. Parra-Arrondo, J.-C. Espinosa); Basque Foundation for Science, Bilbao, Spain (J. Castilla); Ecole Nationale Vétérinaire de Toulouse, Toulouse, France (O. Andréoletti); Hospitalet de Llobregat, Barcelona, Spain (I. Ferrer); Universidad Miguel Hernandez, Sant Joan d´Alacant, Spain (J. Manzanares)

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Figure 6

Vacuolar lesion profile in brains from BoPrP-Tg110 mice inoculated with bovine spongiform encephalopathy (BSE)-C (black circles, n = 6 animals), BSE-H (black triangles, n = 6 animals), BSE-L (black squares, n = 5 animals), 113L-BSE second passage (black squares, n = 5 animals), and 113L-BSE third passage (open diamonds, n = 5 animals) prions. Lesion scoring was conducted for 9 areas of gray matter (G) and 3 areas of white matter (W) in mouse brains. G1, dorsal medulla; G2, cerebellar cortex; G3,

Figure 6. . . Vacuolar lesion profile in brains from BoPrP-Tg110 mice inoculated with bovine spongiform encephalopathy (BSE)-C (black circles, n = 6 animals), BSE-H (black triangles, n = 6 animals), BSE-L (black squares, n = 5 animals), 113L-BSE second passage (black squares, n = 5 animals), and 113L-BSE third passage (open diamonds, n = 5 animals) prions. Lesion scoring was conducted for 9 areas of gray matter (G) and 3 areas of white matter (W) in mouse brains. G1, dorsal medulla; G2, cerebellar cortex; G3, superior colliculus; G4, hypothalamus; G5, medial thalamus; G6, hippocampus; G7, septum; G8, medial cerebral cortex at the level of the thalamus; G9, medial cerebral cortex at the level of the septum (G9); W1, cerebellum; W2, mesencephalic tegmentum; W3, pyramidel tract. BoPrP, bovine prion protein; 113L, leucine substitution at codon 113. Error bars indicate SE.

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