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Volume 12, Number 4—April 2006
Research

Animals as Sentinels of Bioterrorism Agents

Peter Rabinowitz*Comments to Author , Zimra Gordon*†, Daniel Chudnov*, Matthew Wilcox*, Lynda Odofin*, Ann Liu*, and Joshua Dein‡
Author affiliations: *Yale University School of Medicine, New Haven, Connecticut, USA; †Rippowam Animal Hospital, Stamford, Connecticut, USA; ‡US Geological Survey National Wildlife Health Center, Madison, Wisconsin, USA

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Table

Evidence for animals as sentinels of bioterrorism agents*

Agent/disease Animals provide early warning of acute bioterrorism attack Animals could be markers for ongoing exposure risk Animals can propagate/maintain epidemic
Category A
Anthrax Yes: sheep, cattle (level 3 evidence [6])
No: dogs and pigs (level 1 evidence [7]) Yes: sheep, cattle (level 3 evidence [6,8])
Plague Yes: cats (level 1 evidence [9]) Yes: dogs, cats (level 1 evidence [9]), multiple species (level 2 evidence [10]) Yes: cats, camels, goats (level 3 evidence [11,12])
Tularemia No (level 3 evidence [13]) Yes: rodents (level 2 evidence [14])
No: horses, cows (level 2 evidence [13]) Yes: ticks, rodents, prairie dogs (level 2 evidence [15])
Botulism No (level 3 evidence [16]) No (level 3 evidence [16]) No (level 3 evidence [16)
Filovirus infection Yes: wildlife (level 3 evidence [17])
Category B
Q fever No: sheep (level 1 evidence [18]) Yes: wild hogs, goats (level 2 evidence [19,20]) Yes: cats, sheep, goat, cattle (level 3 evidence [21])
Brucellosis No (level 3 evidence [3]) Yes: cattle (level 2 [22]) Yes: wildlife, cattle, dogs (level 3 evidence [23])
Foodborne illness: Salmonella spp; Shigella spp.; Cryptosporidium spp, etc. Yes: cattle (level 3 evidence [24])
Glanders Yes: horses (level 2 evidence [25]) Yes: horses (level 3 evidence [26])
Alphaviruses (VEE/EEE) Yes: horses (level 3 evidence [26])) Yes: birds (level 1 evidence [27]) Yes: wild birds (level 2 evidence [27])
Rift valley fever Yes: cattle, sheep (level 3 evidence [23]) Yes: sheep (level 1 evidence [28]) Yes: mosquitoes, rodents (level 1 evidence [29])
Ricin toxin
Epsilon toxin
Category C (emerging diseases)
Nipah virus Yes: multiple species (level 3 evidence [30]) Yes: pigs (level 1 evidence [31])
Hantavirus No (level 2 evidence [32]) Yes: multiple species (level 2 evidence [32]) Yes: rodents (level 2 evidence [33])
Flavivirus (WN, JE) Yes: wild birds (level 3 evidence [34]) Yes: mosquitoes, birds (level 2 evidence [35]) Yes: birds (level 1 evidence [36])

*Level 1 evidence, experimental or cohort study or randomized clinical trial; level 2 evidence, case-control or cross-sectional study; level 3 evidence, case reports or case series, expert opinion; .–, insufficient evidence found; VEE/EEE, Venezuelan equine encephalitis /eastern equine encephalitis; WN, West Nile; JE, Japanese encephalitis.

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