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Synopses

Medscape CME Activity
Clinical Manifestations, Risk Factors, and Disease Burden of Rickettsiosis, Cambodia, 2007–2020 [PDF - 1.70 MB - 12 pages]
G. C. Kelly et al.

During 2007–2020, we conducted a cross-sectional prevalence study among patients with acute undifferentiated febrile illness to describe the burden and long-term epidemiology of rickettsioses in Cambodia. Serum samples were collected from 10,243 participants, along with epidemiologic data, information on clinical symptoms, demographic characteristics, and risk factors. A total of 802 (7.8%) participants met the definition for acute rickettsial infection after ruling out malaria, influenza, dengue, and chikungunya; 557 (5.4%) cases were typhus, 154 (1.5%) spotted fever, and 136 (1.3%) scrub typhus. Overall seroprevalence was 18.1% (1,857/10,243). Increased age, residence in urban settings, and recent travel to forests were significantly associated with rickettsial infection. Symptoms significantly associated with infection included rash, vomiting, and skin lesions. Our results confirm the underlying burden of rickettsioses and associated risk factors in Cambodia and highlight the need for accessible diagnostics and clinical guidance that consider rickettsioses when treating persons with acute undifferentiated febrile illness.

EID Kelly GC, Rachmat A, Tran L, Supaprom C, Phireak H, Prom S, et al. Clinical Manifestations, Risk Factors, and Disease Burden of Rickettsiosis, Cambodia, 2007–2020. Emerg Infect Dis. 2025;31(6):1069-1080. https://doi.org/10.3201/eid3106.241752
AMA Kelly GC, Rachmat A, Tran L, et al. Clinical Manifestations, Risk Factors, and Disease Burden of Rickettsiosis, Cambodia, 2007–2020. Emerging Infectious Diseases. 2025;31(6):1069-1080. doi:10.3201/eid3106.241752.
APA Kelly, G. C., Rachmat, A., Tran, L., Supaprom, C., Phireak, H., Prom, S....Letizia, A. G. (2025). Clinical Manifestations, Risk Factors, and Disease Burden of Rickettsiosis, Cambodia, 2007–2020. Emerging Infectious Diseases, 31(6), 1069-1080. https://doi.org/10.3201/eid3106.241752.

Medscape CME Activity
Multicenter Retrospective Study of Spiroplasma ixodetis Infantile Cataract in 8 Countries in Europe [PDF - 1.43 MB - 9 pages]
L. Van Os et al.

Spiroplasma ixodetis has been reported to cause the rare combination of cataract and uveitis in infants. Through a retrospective analysis of available literature and additional unpublished cases, we identified 28 eyes from 18 infants from 8 countries in Europe with cataracts and intraocular inflammation. The cataracts were bilateral in 55.6%, unilateral in 44.4%, and progressive in 46.4% of patients. Granulomatous anterior uveitis was found in all infants. Presence of S. ixodetis was supported by PCR (positive in 89.3% of eyes tested), transmission electron microscopy (positive in 90% of eyes tested), or culture of aspirated lens material (positive in 87.5% of eyes tested). Treatment with macrolide antimicrobial drugs, corticosteroids, and lensectomy appeared to be effective. Two patients had a recurrence of the uveitis after lens extraction and needed prolonged treatment. To increase awareness of S. ixodetis, we suggest its inclusion with the organisms of the TORCH acronym.

EID Van Os L, Cassoux N, Cholidis S, Dureau P, Farassat N, Fierz F, et al. Multicenter Retrospective Study of Spiroplasma ixodetis Infantile Cataract in 8 Countries in Europe. Emerg Infect Dis. 2025;31(6):1081-1089. https://doi.org/10.3201/eid3106.240954
AMA Van Os L, Cassoux N, Cholidis S, et al. Multicenter Retrospective Study of Spiroplasma ixodetis Infantile Cataract in 8 Countries in Europe. Emerging Infectious Diseases. 2025;31(6):1081-1089. doi:10.3201/eid3106.240954.
APA Van Os, L., Cassoux, N., Cholidis, S., Dureau, P., Farassat, N., Fierz, F....Lorenz, B. (2025). Multicenter Retrospective Study of Spiroplasma ixodetis Infantile Cataract in 8 Countries in Europe. Emerging Infectious Diseases, 31(6), 1081-1089. https://doi.org/10.3201/eid3106.240954.

Genomic Surveillance of Climate-Amplified Cholera Outbreak, Malawi, 2022–2023 [PDF - 1.55 MB - 10 pages]
L. Chabuka et al.

In the aftermath of 2 extreme weather events in 2022, Malawi experienced a severe cholera outbreak; 59,325 cases and 1,774 deaths were reported by March 31, 2024. We generated 49 Vibrio cholerae full genomes from isolates collected during December 2022–March 2023. Phylogenetic and phylogeographic methods confirmed that the Malawi outbreak strains originated from Pakistan’s 2022 cholera outbreak. That finding aligns with substantial travel between the 2 countries. The estimated most recent ancestor of this lineage was from June–August 2022, coinciding with Pakistan’s floods and cholera surge. Our analysis indicates that major floods in Malawi contributed to the outbreak; reproduction numbers peaked in late December 2022. We conclude that extreme weather events and humanitarian crises in Malawi created conditions conducive to the spread of cholera, and population displacement likely contributed to transmission to susceptible populations in areas relatively unaffected by cholera for more than a decade.

EID Chabuka L, Choga WT, Mavian CN, Moir M, Morgenstern C, Tegaly H, et al. Genomic Surveillance of Climate-Amplified Cholera Outbreak, Malawi, 2022–2023. Emerg Infect Dis. 2025;31(6):1090-1099. https://doi.org/10.3201/eid3106.240930
AMA Chabuka L, Choga WT, Mavian CN, et al. Genomic Surveillance of Climate-Amplified Cholera Outbreak, Malawi, 2022–2023. Emerging Infectious Diseases. 2025;31(6):1090-1099. doi:10.3201/eid3106.240930.
APA Chabuka, L., Choga, W. T., Mavian, C. N., Moir, M., Morgenstern, C., Tegaly, H....Kagoli, M. (2025). Genomic Surveillance of Climate-Amplified Cholera Outbreak, Malawi, 2022–2023. Emerging Infectious Diseases, 31(6), 1090-1099. https://doi.org/10.3201/eid3106.240930.
Research

Genesis and Spread of Novel Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Genotype EA-2023-DG Reassortant, Western Europe [PDF - 1.23 MB - 9 pages]
S. Van Borm et al.

In Europe, highly pathogenic avian influenza (HPAI) virus circulates in avian wildlife, undergoing frequent reassortment, sporadic introductions in domestic birds, and spillover to mammals. An H5N1 clade 2.3.4.4b reassortant, EA-2023-DG, affecting wild and domestic birds was detected in western Europe in November 2023. Six of its RNA segments came from the EA-2021-AB genotype, but the polymerase basic 2 and polymerase acidic segments originated from low pathogenicity avian influenza viruses. Discrete phylogeographic analyses of concatenated genomes and single polymerase basic 2 and polymerase acidic segments suggested reassortment in summer 2023 near the southwestern Baltic Sea. Subsequent continuous phylogeographic analysis of all concatenated EA-2023-DG genomes highlighted circulation in northwestern Europe until June 2024 and long-distance dispersal toward France, Norway, England, Slovakia, Switzerland, and Austria. Those results illustrate the value of phylodynamic approaches to investigate emergence of novel avian influenza virus variants, trace their subsequent dispersal history, and provide vital clues for informing outbreak prevention and intervention policies.

EID Van Borm S, Ahrens A, Bachofen C, Banyard AC, Bøe C, Briand F, et al. Genesis and Spread of Novel Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Genotype EA-2023-DG Reassortant, Western Europe. Emerg Infect Dis. 2025;31(6):1100-1108. https://doi.org/10.3201/eid3106.241870
AMA Van Borm S, Ahrens A, Bachofen C, et al. Genesis and Spread of Novel Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Genotype EA-2023-DG Reassortant, Western Europe. Emerging Infectious Diseases. 2025;31(6):1100-1108. doi:10.3201/eid3106.241870.
APA Van Borm, S., Ahrens, A., Bachofen, C., Banyard, A. C., Bøe, C., Briand, F....Dellicour, S. (2025). Genesis and Spread of Novel Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Genotype EA-2023-DG Reassortant, Western Europe. Emerging Infectious Diseases, 31(6), 1100-1108. https://doi.org/10.3201/eid3106.241870.

Characterization of Adult and Pediatric Healthcare-Associated and Community-Associated Clostridioides difficile Infections, Canada, 2015–2022 [PDF - 1.16 MB - 12 pages]
T. Du et al.

We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) Clostridioides difficile infection (CDI) among adult and pediatric patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015–2022. Of 30,824 reported CDI cases, 94.9% (29,250/30,824) were among adult (73.2% HA; 26.8% CA) and 5.1% (1,574/30,824) pediatric (77.6% HA; 22.4% CA) patients. During the study period, adult HA CDI rates decreased by 19.9% and CA CDI rates remained stable; pediatric HA CDI rates decreased by 29.6% and CA CDI decreased by 58.3%. Ribotype (RT) 106 was most common among both groups and replaced RT027 as the predominant strain type. RT027 was most associated with adult patients, HA acquisition, severe CDI, and severe outcomes. Moxifloxacin resistance was higher in adult than pediatric cases; clindamycin and rifampin resistance rates were similar between groups. Continued national surveillance is integral to understanding the epidemiology of adult and pediatric CDI in Canada and informing prevention efforts.

EID Du T, Silva A, Choi KB, Lybeck C, Golding GR, Hizon R, et al. Characterization of Adult and Pediatric Healthcare-Associated and Community-Associated Clostridioides difficile Infections, Canada, 2015–2022. Emerg Infect Dis. 2025;31(6):1109-1120. https://doi.org/10.3201/eid3106.250182
AMA Du T, Silva A, Choi KB, et al. Characterization of Adult and Pediatric Healthcare-Associated and Community-Associated Clostridioides difficile Infections, Canada, 2015–2022. Emerging Infectious Diseases. 2025;31(6):1109-1120. doi:10.3201/eid3106.250182.
APA Du, T., Silva, A., Choi, K. B., Lybeck, C., Golding, G. R., Hizon, R....Hota, S. S. (2025). Characterization of Adult and Pediatric Healthcare-Associated and Community-Associated Clostridioides difficile Infections, Canada, 2015–2022. Emerging Infectious Diseases, 31(6), 1109-1120. https://doi.org/10.3201/eid3106.250182.

Prospective Multicenter Surveillance of Non–H. pylori Helicobacter Infections during Medical Checkups, Japan [PDF - 1.35 MB - 10 pages]
K. Tokunaga et al.

To evaluate non–H. pylori Helicobacter (NHPH) infections in Japan, we enrolled 673 consecutive patients who underwent gastric endoscopy during annual medical checkups at 4 hospitals during April 2022–February 2023. We collected intragastric fluid and serum samples to detect NHPH infection by PCR and serologic tests. The prevalence of NHPH was 3% (20/673); 70% (14/20) of patients were infected with H. suis and 30% (6/20) with non–H. suis NHPH species. All 14 H. suis–infected patients were men and had a history of pork offal ingestion. Among non–H. suis NHPH-infected patients, 50% (3/6) owned pet cats, whereas only 22% (145/667) of other patients owned cats. Endoscopic evaluation revealed marbled crack-like gastritis was present in 93% (13/14) of H. suis–infected patients, a significantly higher prevalence than for H. pylori–infected (28.6%) and H. pylori eradication therapy (27.6%) groups. Pork offal ingestion and having pet cats increase risk for Helicobacter spp. infections.

EID Tokunaga K, Rimbara E, Tsukadaira T, Mabe K, Yahara K, Suzuki H, et al. Prospective Multicenter Surveillance of Non–H. pylori Helicobacter Infections during Medical Checkups, Japan. Emerg Infect Dis. 2025;31(6):1121-1130. https://doi.org/10.3201/eid3106.241315
AMA Tokunaga K, Rimbara E, Tsukadaira T, et al. Prospective Multicenter Surveillance of Non–H. pylori Helicobacter Infections during Medical Checkups, Japan. Emerging Infectious Diseases. 2025;31(6):1121-1130. doi:10.3201/eid3106.241315.
APA Tokunaga, K., Rimbara, E., Tsukadaira, T., Mabe, K., Yahara, K., Suzuki, H....Kato, M. (2025). Prospective Multicenter Surveillance of Non–H. pylori Helicobacter Infections during Medical Checkups, Japan. Emerging Infectious Diseases, 31(6), 1121-1130. https://doi.org/10.3201/eid3106.241315.

Safety and Immunogenicity of Poultry Vaccine for Protecting Critically Endangered Avian Species against Highly Pathogenic Avian Influenza Virus, United States [PDF - 921 KB - 9 pages]
T. E. Katzner et al.

In 2023, an outbreak of highly pathogenic avian influenza occurred among critically endangered California condors (Gymnogyps californianus), and >21 died. We evaluated safety, immunogenicity, vaccination strategies, and correlates of antibody response of an influenza vaccine for poultry in black vultures (Coragyps atratus) and then California condors. We noted differences in antibody titers between vaccinated and unvaccinated birds (vultures p<0.004; condors p­<0.02) but no adverse effects of vaccination. All vaccinated vultures and 80% of vaccinated condors showed maximum measured antibody response within the published range associated with survival of vaccinated and virally challenged chickens. We noted weak evidence of higher antibody responses for birds given two 0.5-mL vaccines versus those given one 1-mL vaccine but no correlation between antibody titers and sex for either species or between antibody titers and bone lead concentrations in vultures. Our results prompted initiation of a vaccination program for condors that could reduce spread of this disease among highly threatened species.

EID Katzner TE, Blackford AV, Donahue M, Gibbs S, Lenoch J, Martin M, et al. Safety and Immunogenicity of Poultry Vaccine for Protecting Critically Endangered Avian Species against Highly Pathogenic Avian Influenza Virus, United States. Emerg Infect Dis. 2025;31(6):1131-1139. https://doi.org/10.3201/eid3106.241558
AMA Katzner TE, Blackford AV, Donahue M, et al. Safety and Immunogenicity of Poultry Vaccine for Protecting Critically Endangered Avian Species against Highly Pathogenic Avian Influenza Virus, United States. Emerging Infectious Diseases. 2025;31(6):1131-1139. doi:10.3201/eid3106.241558.
APA Katzner, T. E., Blackford, A. V., Donahue, M., Gibbs, S., Lenoch, J., Martin, M....Suarez, D. L. (2025). Safety and Immunogenicity of Poultry Vaccine for Protecting Critically Endangered Avian Species against Highly Pathogenic Avian Influenza Virus, United States. Emerging Infectious Diseases, 31(6), 1131-1139. https://doi.org/10.3201/eid3106.241558.

Diagnostic Accuracy of 3 Mpox Lateral Flow Assays for Antigen Detection, Democratic Republic of the Congo and United Kingdom [PDF - 726 KB - 9 pages]
E. Ishara-Nshombo et al.

The ongoing outbreaks of mpox highlight the urgent need for a rapid and low-cost diagnostic test to accurately detect and control this emerging disease. We estimated the analytical sensitivity using viral culture of the monkeypox virus clade IIb lineage B1 and clinical diagnostic performance of 3 antigen detection rapid diagnostic tests (Ag-RDT) by using skin swab samples and upper-respiratory swab samples from mpox patients in the Democratic Republic of the Congo and the United Kingdom. The analytical limit of detection was 1.0 × 104 plaque-forming units/mL, fulfilling World Health Organization recommendations. Specificity of the 3 Ag-RDTs was 100%, but sensitivity was estimated at 0.00%–15.79% using skin samples and 0.00% using respiratory samples. None of the 3 Ag-RDTs reached the World Health Organization’s target clinical sensitivity, and we do not recommend them as diagnostic or screening tools for suspected mpox cases. Accurate Ag-RDTs for mpox diagnosis remain urgently needed.

EID Ishara-Nshombo E, Somasundaran A, Romero-Ramirez A, Kontogianni K, Mukadi-Bamuleka D, Mukoka-Ntumba M, et al. Diagnostic Accuracy of 3 Mpox Lateral Flow Assays for Antigen Detection, Democratic Republic of the Congo and United Kingdom. Emerg Infect Dis. 2025;31(6):1140-1148. https://doi.org/10.3201/eid3106.250166
AMA Ishara-Nshombo E, Somasundaran A, Romero-Ramirez A, et al. Diagnostic Accuracy of 3 Mpox Lateral Flow Assays for Antigen Detection, Democratic Republic of the Congo and United Kingdom. Emerging Infectious Diseases. 2025;31(6):1140-1148. doi:10.3201/eid3106.250166.
APA Ishara-Nshombo, E., Somasundaran, A., Romero-Ramirez, A., Kontogianni, K., Mukadi-Bamuleka, D., Mukoka-Ntumba, M....Cubas-Atienzar, A. (2025). Diagnostic Accuracy of 3 Mpox Lateral Flow Assays for Antigen Detection, Democratic Republic of the Congo and United Kingdom. Emerging Infectious Diseases, 31(6), 1140-1148. https://doi.org/10.3201/eid3106.250166.

Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand [PDF - 895 KB - 9 pages]
E. Rapheal et al.

Dengue is a major cause of illness among local populations and travelers in dengue-endemic areas, particularly those who stay for an extended period. However, little is known about dengue risk among expatriates and other long-term travelers. We used catalytic models of force of infection to estimate time to 60% dengue virus (DENV) seropositivity for a cross-section of expatriates living in Bangkok and Pattaya, Thailand. Our model adjusted for daily time spent outside, years not exposed to DENV, sex, living environment, and use of mosquito repellent, nets, long sleeves, and air conditioning. We estimated an adjusted annual force of infection of 0.014 (95% CI 0.003–0.054) per year spent in dengue-endemic areas (67.3 years to 60% seropositivity), below that of local populations. Our findings suggest that expatriates have a DENV exposure profile distinct from locals and short-term travelers and should likely be considered independently when developing vaccine and prevention recommendations.

EID Rapheal E, Kitro A, Imad H, Hamins-Peurtolas M, Olanwijitwong J, Chatapat L, et al. Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand. Emerg Infect Dis. 2025;31(6):1149-1157. https://doi.org/10.3201/eid3106.241686
AMA Rapheal E, Kitro A, Imad H, et al. Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand. Emerging Infectious Diseases. 2025;31(6):1149-1157. doi:10.3201/eid3106.241686.
APA Rapheal, E., Kitro, A., Imad, H., Hamins-Peurtolas, M., Olanwijitwong, J., Chatapat, L....Piyaphanee, W. (2025). Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand. Emerging Infectious Diseases, 31(6), 1149-1157. https://doi.org/10.3201/eid3106.241686.

Long-Term Clinical Outcomes of Adults Hospitalized for COVID-19 Pneumonia [PDF - 1.47 MB - 11 pages]
I. O. Rosas et al.

We conducted a multicenter, observational, 12-month follow-up study to identify the extended health burden of severe COVID-19 pneumonia by characterizing long-term sequelae of acute infection in participants previously enrolled in clinical trials for severe COVID-19 pneumonia requiring hospitalization. Overall, 134 (77.5%) of 173 participants completed the study. At 12 months, 51 (29.5%) participants reported cough, 60 (34.7%) reported dyspnea, 56 (32.4%) had residual lung texture abnormalities on high-resolution computed tomography scans, 26 (15.0%) had impaired forced vital capacity, 52 (30.1%) had cognitive impairment, and 77 (44.5%) reported fatigue. Disease severity during acute infection and age were associated with persistent lung texture abnormalities; history of hypertension was associated with higher prevalence of fatigue and more frequent dyspnea and cough; and age and obesity were associated with long-term cognitive impairment. Our findings underscore the long-term health burden of severe COVID-19 pneumonia, reinforcing the importance of regular monitoring in older persons and those with underlying illnesses.

EID Rosas IO, Benitez A, McKinnell JA, Shah R, Waters M, Hunter BD, et al. Long-Term Clinical Outcomes of Adults Hospitalized for COVID-19 Pneumonia. Emerg Infect Dis. 2025;31(6):1158-1168. https://doi.org/10.3201/eid3106.241097
AMA Rosas IO, Benitez A, McKinnell JA, et al. Long-Term Clinical Outcomes of Adults Hospitalized for COVID-19 Pneumonia. Emerging Infectious Diseases. 2025;31(6):1158-1168. doi:10.3201/eid3106.241097.
APA Rosas, I. O., Benitez, A., McKinnell, J. A., Shah, R., Waters, M., Hunter, B. D....Cai, F. (2025). Long-Term Clinical Outcomes of Adults Hospitalized for COVID-19 Pneumonia. Emerging Infectious Diseases, 31(6), 1158-1168. https://doi.org/10.3201/eid3106.241097.

High Genetic Diversity of Histoplasma in the Amazon Basin, 2006–2017 [PDF - 1.15 MB - 9 pages]
T. Ly et al.

Histoplasmosis is one of the most common pulmonary mycosis diseases in the world. Genome sequencing has revealed that Histoplasma, the cause of histoplasmosis, is composed of several phylogenetic species. The genetic diversity of the pathogen remains largely unknown, especially in the tropics. We sequenced the genomes of 91 Histoplasma isolates from the Amazon basin of South America and used phylogenomics and population genetic evidence to measure the genetic variation of the genus in South America. We report a previously unidentified clade of Histoplasma endemic to the Amazon basin. The lineage is widespread across the continent and contains 5 lineages that are sufficiently differentiated to be considered phylogenetic species. We found the geographic range of those lineages is largely but not completely overlapping. Finally, we found that the patient median age and sex ratio differs among species, suggesting differences in the epidemiology of histoplasmosis caused by each Histoplasma lineage.

EID Ly T, de Melo Teixeira M, Jofre GI, Blanchet D, MacDonald S, Alvarado P, et al. High Genetic Diversity of Histoplasma in the Amazon Basin, 2006–2017. Emerg Infect Dis. 2025;31(6):1169-1177. https://doi.org/10.3201/eid3106.241386
AMA Ly T, de Melo Teixeira M, Jofre GI, et al. High Genetic Diversity of Histoplasma in the Amazon Basin, 2006–2017. Emerging Infectious Diseases. 2025;31(6):1169-1177. doi:10.3201/eid3106.241386.
APA Ly, T., de Melo Teixeira, M., Jofre, G. I., Blanchet, D., MacDonald, S., Alvarado, P....Matute, D. R. (2025). High Genetic Diversity of Histoplasma in the Amazon Basin, 2006–2017. Emerging Infectious Diseases, 31(6), 1169-1177. https://doi.org/10.3201/eid3106.241386.

Emergence of Oropouche Virus in Espírito Santo State, Brazil, 2024 [PDF - 1.77 MB - 11 pages]
E. Delatorre et al.

Oropouche virus (OROV), historically endemic to the Amazon, had spread to nearly all Brazil states by 2024; Espírito Santo emerged as a transmission hotspot in the Atlantic Forest biome. We characterized the epidemiologic factors driving OROV spread in nonendemic southeast Brazil, analyzing environmental and agricultural conditions contributing to viral transmission. We tested samples from 29,080 suspected arbovirus-infected patients quantitative reverse transcription PCR for OROV and dengue, chikungunya, Zika, and Mayaro viruses. During March‒June 2024, the state had 339 confirmed OROV cases, demonstrating successful local transmission. Spatial analysis revealed that most cases clustered in municipalities with tropical climates and intensive cacao, robusta coffee, coconut, and pepper cultivation. Phylogenetic analysis identified the Espírito Santo OROV strains as part of the 2022–2024 Amazon lineage. The rapid spread of OROV outside the Amazon highlights its adaptive potential and public health threat, emphasizing the need for enhanced surveillance and targeted control measures.

EID Delatorre E, de Mendonça G, Gatti F, Có A, del Piero Pereira J, Tavares E, et al. Emergence of Oropouche Virus in Espírito Santo State, Brazil, 2024. Emerg Infect Dis. 2025;31(6):1178-1188. https://doi.org/10.3201/eid3106.241946
AMA Delatorre E, de Mendonça G, Gatti F, et al. Emergence of Oropouche Virus in Espírito Santo State, Brazil, 2024. Emerging Infectious Diseases. 2025;31(6):1178-1188. doi:10.3201/eid3106.241946.
APA Delatorre, E., de Mendonça, G., Gatti, F., Có, A., del Piero Pereira, J., Tavares, E....Ribeiro-Rodrigues, R. (2025). Emergence of Oropouche Virus in Espírito Santo State, Brazil, 2024. Emerging Infectious Diseases, 31(6), 1178-1188. https://doi.org/10.3201/eid3106.241946.
Dispatches

Cadaveric Human Growth Hormone–Associated Creutzfeldt-Jakob Disease with Long Latency Period, United States [PDF - 1.16 MB - 4 pages]
A. S. Ribeiro et al.

We report a case of iatrogenic Creutzfeldt-Jakob disease (iCJD) after a 48.3-year incubation period in a patient treated with cadaveric human growth hormone. iCJD was pathologically confirmed; genetic analysis was negative for pathogenic mutations. Clinicians should consider iCJD in patients with progressive neurologic signs who had received cadaveric human growth hormone treatment.

EID Ribeiro AS, Wolf AB, Leschek EW, Schonberger LB, Abrams JY, Maddox RA, et al. Cadaveric Human Growth Hormone–Associated Creutzfeldt-Jakob Disease with Long Latency Period, United States. Emerg Infect Dis. 2025;31(6):1189-1192. https://doi.org/10.3201/eid3106.241519
AMA Ribeiro AS, Wolf AB, Leschek EW, et al. Cadaveric Human Growth Hormone–Associated Creutzfeldt-Jakob Disease with Long Latency Period, United States. Emerging Infectious Diseases. 2025;31(6):1189-1192. doi:10.3201/eid3106.241519.
APA Ribeiro, A. S., Wolf, A. B., Leschek, E. W., Schonberger, L. B., Abrams, J. Y., Maddox, R. A....Matthews, E. (2025). Cadaveric Human Growth Hormone–Associated Creutzfeldt-Jakob Disease with Long Latency Period, United States. Emerging Infectious Diseases, 31(6), 1189-1192. https://doi.org/10.3201/eid3106.241519.

Oral Flea Preventive to Control Rickettsia typhi–Infected Fleas on Reservoir Opossums, Galveston, Texas, USA, 2023–2024 [PDF - 871 KB - 4 pages]
L. S. Blanton and A. Villasante-Tezanos

Murine typhus, a fleaborne bacterial disease caused by Rickettsia typhi, has reemerged and spread in the United States. We tested spinosad, an oral flea preventive, in opossum flea reservoirs. Spinosad killed 98% of fleas infesting opossums. Oral preventives could control fleas in host species and curb murine typhus spread to humans.

EID Blanton LS, Villasante-Tezanos A. Oral Flea Preventive to Control Rickettsia typhi–Infected Fleas on Reservoir Opossums, Galveston, Texas, USA, 2023–2024. Emerg Infect Dis. 2025;31(6):1193-1196. https://doi.org/10.3201/eid3106.241817
AMA Blanton LS, Villasante-Tezanos A. Oral Flea Preventive to Control Rickettsia typhi–Infected Fleas on Reservoir Opossums, Galveston, Texas, USA, 2023–2024. Emerging Infectious Diseases. 2025;31(6):1193-1196. doi:10.3201/eid3106.241817.
APA Blanton, L. S., & Villasante-Tezanos, A. (2025). Oral Flea Preventive to Control Rickettsia typhi–Infected Fleas on Reservoir Opossums, Galveston, Texas, USA, 2023–2024. Emerging Infectious Diseases, 31(6), 1193-1196. https://doi.org/10.3201/eid3106.241817.

OXA-204 Carbapenemase in Clinical Isolate of Pseudomonas guariconensis, Tunisia [PDF - 1.13 MB - 5 pages]
N. Jaidane et al.

We report an OXA-204–producing Pseudomonas guariconensis clinical isolate in Tunisia, proving the spread of OXA-48 variants beyond Enterobacterales. The blaOXA-204 gene was carried on a 119-kb chromosomally integrated plasmid fragment, along with multiple additional resistance genes. Surveillance, diagnostic tools, and antimicrobial drug access are needed to mitigate spread of carbapenem-resistant pathogens.

EID Jaidane N, Mansour W, Tilouche L, Châtre P, François P, Lupo A, et al. OXA-204 Carbapenemase in Clinical Isolate of Pseudomonas guariconensis, Tunisia. Emerg Infect Dis. 2025;31(6):1197-1201. https://doi.org/10.3201/eid3106.250131
AMA Jaidane N, Mansour W, Tilouche L, et al. OXA-204 Carbapenemase in Clinical Isolate of Pseudomonas guariconensis, Tunisia. Emerging Infectious Diseases. 2025;31(6):1197-1201. doi:10.3201/eid3106.250131.
APA Jaidane, N., Mansour, W., Tilouche, L., Châtre, P., François, P., Lupo, A....Naas, T. (2025). OXA-204 Carbapenemase in Clinical Isolate of Pseudomonas guariconensis, Tunisia. Emerging Infectious Diseases, 31(6), 1197-1201. https://doi.org/10.3201/eid3106.250131.

Investigation of Influenza A(H5N1) Virus Neutralization by Quadrivalent Seasonal Vaccines, United Kingdom, 2021–2024 [PDF - 658 KB - 5 pages]
P. Stevenson-Leggett et al.

We tested cross-neutralization against highly pathogenic avian influenza A(H5N1) virus in adults vaccinated with 2021–2023 seasonal quadrivalent influenza vaccine in the United Kingdom. Seasonal quadrivalent influenza vaccines are unlikely to protect vulnerable persons against severe H5N1 disease during widespread transmission. Enhanced measures are needed to protect vulnerable people from H5N1 virus infection.

EID Stevenson-Leggett P, Adams L, Greenwood D, Lofts A, Libri V, Williams B, et al. Investigation of Influenza A(H5N1) Virus Neutralization by Quadrivalent Seasonal Vaccines, United Kingdom, 2021–2024. Emerg Infect Dis. 2025;31(6):1202-1206. https://doi.org/10.3201/eid3106.241796
AMA Stevenson-Leggett P, Adams L, Greenwood D, et al. Investigation of Influenza A(H5N1) Virus Neutralization by Quadrivalent Seasonal Vaccines, United Kingdom, 2021–2024. Emerging Infectious Diseases. 2025;31(6):1202-1206. doi:10.3201/eid3106.241796.
APA Stevenson-Leggett, P., Adams, L., Greenwood, D., Lofts, A., Libri, V., Williams, B....Wall, E. C. (2025). Investigation of Influenza A(H5N1) Virus Neutralization by Quadrivalent Seasonal Vaccines, United Kingdom, 2021–2024. Emerging Infectious Diseases, 31(6), 1202-1206. https://doi.org/10.3201/eid3106.241796.

Mycoplasma arginini Cellulitis, Tenosynovitis, and Arthritis in Kidney Transplant Recipient, Slovenia, 2024 [PDF - 1.04 MB - 4 pages]
T. Vivoda et al.

Mycoplasma arginini is a bacterium primarily found in animals and is seldom reported in human infections. We identified M. arginini infection in a severely immunocompromised kidney transplant recipient in Slovenia. Clinicians should be aware of M. arginini’s potential as a pathogen in immunocompromised persons with animal contact.

EID Vivoda T, Rojko T, Ulčar B, Smrdel K, Šturm A, Keše D, et al. Mycoplasma arginini Cellulitis, Tenosynovitis, and Arthritis in Kidney Transplant Recipient, Slovenia, 2024. Emerg Infect Dis. 2025;31(6):1207-1210. https://doi.org/10.3201/eid3106.250149
AMA Vivoda T, Rojko T, Ulčar B, et al. Mycoplasma arginini Cellulitis, Tenosynovitis, and Arthritis in Kidney Transplant Recipient, Slovenia, 2024. Emerging Infectious Diseases. 2025;31(6):1207-1210. doi:10.3201/eid3106.250149.
APA Vivoda, T., Rojko, T., Ulčar, B., Smrdel, K., Šturm, A., Keše, D....Haler, Ž. (2025). Mycoplasma arginini Cellulitis, Tenosynovitis, and Arthritis in Kidney Transplant Recipient, Slovenia, 2024. Emerging Infectious Diseases, 31(6), 1207-1210. https://doi.org/10.3201/eid3106.250149.

High Prevalence of Artemisinin-Resistant Plasmodium falciparum, Southeastern Sudan [PDF - 467 KB - 5 pages]
M. L’Episcopia et al.

We conducted a hospital-based cross-sectional study of Plasmodium falciparum in 2017 in southeastern Sudan. Among 257 P. falciparum samples, we found 22% harbored the pfkelch13 R622I mutation and 10.7% showed hrp2/3 gene deletions. Our findings highlight the urgent need for enhanced surveillance of drug- and diagnostic-resistant parasites in the Horn of Africa.

EID L’Episcopia M, Talha AA, Nour B, Sana I, Caspar E, Thiebaut L, et al. High Prevalence of Artemisinin-Resistant Plasmodium falciparum, Southeastern Sudan. Emerg Infect Dis. 2025;31(6):1211-1215. https://doi.org/10.3201/eid3106.241810
AMA L’Episcopia M, Talha AA, Nour B, et al. High Prevalence of Artemisinin-Resistant Plasmodium falciparum, Southeastern Sudan. Emerging Infectious Diseases. 2025;31(6):1211-1215. doi:10.3201/eid3106.241810.
APA L’Episcopia, M., Talha, A. A., Nour, B., Sana, I., Caspar, E., Thiebaut, L....Menard, D. (2025). High Prevalence of Artemisinin-Resistant Plasmodium falciparum, Southeastern Sudan. Emerging Infectious Diseases, 31(6), 1211-1215. https://doi.org/10.3201/eid3106.241810.

Highly Pathogenic Avian Influenza A(H5N1) in Wild Birds and a Human, British Columbia, Canada, 2024 [PDF - 1.49 MB - 6 pages]
C. G. Himsworth et al.

We characterized highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b genotype D1.1 in wild birds and a human in British Columbia, Canada, during 2024. D1.1, the predominant genotype circulating in fall 2024, is a reassortment between Eurasian A3 lineage viruses, introduced to North America in 2022, and North American lineage viruses.

EID Himsworth CG, Caleta JM, Jassem AN, Yang KC, Zlosnik J, Tyson JR, et al. Highly Pathogenic Avian Influenza A(H5N1) in Wild Birds and a Human, British Columbia, Canada, 2024. Emerg Infect Dis. 2025;31(6):1216-1221. https://doi.org/10.3201/eid3106.241862
AMA Himsworth CG, Caleta JM, Jassem AN, et al. Highly Pathogenic Avian Influenza A(H5N1) in Wild Birds and a Human, British Columbia, Canada, 2024. Emerging Infectious Diseases. 2025;31(6):1216-1221. doi:10.3201/eid3106.241862.
APA Himsworth, C. G., Caleta, J. M., Jassem, A. N., Yang, K. C., Zlosnik, J., Tyson, J. R....Russell, S. L. (2025). Highly Pathogenic Avian Influenza A(H5N1) in Wild Birds and a Human, British Columbia, Canada, 2024. Emerging Infectious Diseases, 31(6), 1216-1221. https://doi.org/10.3201/eid3106.241862.

Dual-Genotype Orientia tsutsugamushi Infections, Hainan Island, China, 2023 [PDF - 578 KB - 4 pages]
Y. Niu et al.

We report 3 cases of dual-genotype Orientia tsutsugamushi infection in Hainan Island, China. Patients exhibited diverse clinical manifestations, including afebrile illness and multiorgan involvement, highlighting the complexity associated with genetic diversity in scrub typhus. Clinicians should maintain heightened suspicion for atypical scrub typhus manifestations in endemic regions.

EID Niu Y, Chen S, Wang G, Guo Y, Ge N, Hu X, et al. Dual-Genotype Orientia tsutsugamushi Infections, Hainan Island, China, 2023. Emerg Infect Dis. 2025;31(6):1222-1225. https://doi.org/10.3201/eid3106.241967
AMA Niu Y, Chen S, Wang G, et al. Dual-Genotype Orientia tsutsugamushi Infections, Hainan Island, China, 2023. Emerging Infectious Diseases. 2025;31(6):1222-1225. doi:10.3201/eid3106.241967.
APA Niu, Y., Chen, S., Wang, G., Guo, Y., Ge, N., Hu, X....Yin, F. (2025). Dual-Genotype Orientia tsutsugamushi Infections, Hainan Island, China, 2023. Emerging Infectious Diseases, 31(6), 1222-1225. https://doi.org/10.3201/eid3106.241967.

Skin Infections Caused by Panton-Valentine Leukocidin and Methicillin-Susceptible Staphylococcus aureus in Child, Japan [PDF - 491 KB - 4 pages]
K. Shoji et al.

We describe a pediatric case of recurrent skin infections caused by a Panton-Valentine leukocidin and exfoliative toxin E double-positive methicillin-susceptible Staphylococcus aureus clonal complex 188 clone. Most of the patient’s family members were infected with the same strain, and intrafamilial transmission was strongly suspected. Decolonization procedures were not effective.

EID Shoji K, Yoshida K, Takenouchi M, Hisatsune J, Kutsuno S, Arai C, et al. Skin Infections Caused by Panton-Valentine Leukocidin and Methicillin-Susceptible Staphylococcus aureus in Child, Japan. Emerg Infect Dis. 2025;31(6):1227-1230. https://doi.org/10.3201/eid3106.241955
AMA Shoji K, Yoshida K, Takenouchi M, et al. Skin Infections Caused by Panton-Valentine Leukocidin and Methicillin-Susceptible Staphylococcus aureus in Child, Japan. Emerging Infectious Diseases. 2025;31(6):1227-1230. doi:10.3201/eid3106.241955.
APA Shoji, K., Yoshida, K., Takenouchi, M., Hisatsune, J., Kutsuno, S., Arai, C....Miyairi, I. (2025). Skin Infections Caused by Panton-Valentine Leukocidin and Methicillin-Susceptible Staphylococcus aureus in Child, Japan. Emerging Infectious Diseases, 31(6), 1227-1230. https://doi.org/10.3201/eid3106.241955.

A One Health Approach to Investigating Cache Valley Virus, Arkansas, USA, July 2023 [PDF - 1.23 MB - 4 pages]
A. Carpenter et al.

Cache Valley virus (CVV), a mosquitoborne virus, can cause neuroinvasive disease in humans and adverse reproductive outcomes in sheep and goats. In 2023, CVV RNA was detected in an aborted lamb from a flock in Arkansas, USA. We conducted a One Health investigation to explore the potential effects of CVV in Arkansas.

EID Carpenter A, Kojima N, Dulski TM, Calvert AE, Burkhalter KL, Ballard JR, et al. A One Health Approach to Investigating Cache Valley Virus, Arkansas, USA, July 2023. Emerg Infect Dis. 2025;31(6):1231-1234. https://doi.org/10.3201/eid3106.250052
AMA Carpenter A, Kojima N, Dulski TM, et al. A One Health Approach to Investigating Cache Valley Virus, Arkansas, USA, July 2023. Emerging Infectious Diseases. 2025;31(6):1231-1234. doi:10.3201/eid3106.250052.
APA Carpenter, A., Kojima, N., Dulski, T. M., Calvert, A. E., Burkhalter, K. L., Ballard, J. R....Burke, J. (2025). A One Health Approach to Investigating Cache Valley Virus, Arkansas, USA, July 2023. Emerging Infectious Diseases, 31(6), 1231-1234. https://doi.org/10.3201/eid3106.250052.

Prevalence of Nitroimidazole-Refractory Giardiasis Acquired in Different World Regions, Sweden, 2008–2020 [PDF - 589 KB - 4 pages]
K. A. Ydsten et al.

Treatment-refractory giardiasis is an emerging clinical problem. Of 4,285 giardiasis cases identified during 2008–2020 in Stockholm, Sweden, 102 (2.4%) were nitroimidazole refractory. Among cases acquired in India, the percentage was high (64/545 [12%]) and increased over time. The region of acquisition needs to be taken into consideration when managing patients.

EID Ydsten KA, Öhd J, Hellgren U, Asgeirsson H. Prevalence of Nitroimidazole-Refractory Giardiasis Acquired in Different World Regions, Sweden, 2008–2020. Emerg Infect Dis. 2025;31(6):1235-1238. https://doi.org/10.3201/eid3106.250076
AMA Ydsten KA, Öhd J, Hellgren U, et al. Prevalence of Nitroimidazole-Refractory Giardiasis Acquired in Different World Regions, Sweden, 2008–2020. Emerging Infectious Diseases. 2025;31(6):1235-1238. doi:10.3201/eid3106.250076.
APA Ydsten, K. A., Öhd, J., Hellgren, U., & Asgeirsson, H. (2025). Prevalence of Nitroimidazole-Refractory Giardiasis Acquired in Different World Regions, Sweden, 2008–2020. Emerging Infectious Diseases, 31(6), 1235-1238. https://doi.org/10.3201/eid3106.250076.

Three Cases of Human Babesiosis, Italy, 2017–2020 [PDF - 1.47 MB - 5 pages]
C. Sepulcri et al.

We report 3 cases of babesiosis in Italy caused by Babesia species that are rarely reported in humans. The circulation of Babesia spp. among vectors, animals, and humans might be more common than previously thought, and babesiosis might be an underdiagnosed and emerging disease in Italy and Europe.

EID Sepulcri C, Pincino R, Baldi F, Cenderello G, Zanet S, Boccolini D, et al. Three Cases of Human Babesiosis, Italy, 2017–2020. Emerg Infect Dis. 2025;31(6):1239-1243. https://doi.org/10.3201/eid3106.241776
AMA Sepulcri C, Pincino R, Baldi F, et al. Three Cases of Human Babesiosis, Italy, 2017–2020. Emerging Infectious Diseases. 2025;31(6):1239-1243. doi:10.3201/eid3106.241776.
APA Sepulcri, C., Pincino, R., Baldi, F., Cenderello, G., Zanet, S., Boccolini, D....Ferroglio, E. (2025). Three Cases of Human Babesiosis, Italy, 2017–2020. Emerging Infectious Diseases, 31(6), 1239-1243. https://doi.org/10.3201/eid3106.241776.
Research Letters

Usutu Virus Antibody Dynamics in Naturally Infected Blackbirds, the Netherlands, 2016–2018 [PDF - 633 KB - 3 pages]
E. de Bruin et al.

Usutu virus is a zoonotic arbovirus that causes massive mortality in blackbirds. Using a unique longitudinal dataset on the kinetics of virus-specific antibodies in naturally infected wild blackbirds (Turdus merula), we found that individual birds may remain seropositive for >1 year and that reinfection can occur despite low-level virus neutralizing antibodies.

EID de Bruin E, van Irsel J, Chandler F, Kohl R, van de Voorde T, van der Linden A, et al. Usutu Virus Antibody Dynamics in Naturally Infected Blackbirds, the Netherlands, 2016–2018. Emerg Infect Dis. 2025;31(6):1244-1246. https://doi.org/10.3201/eid3106.241744
AMA de Bruin E, van Irsel J, Chandler F, et al. Usutu Virus Antibody Dynamics in Naturally Infected Blackbirds, the Netherlands, 2016–2018. Emerging Infectious Diseases. 2025;31(6):1244-1246. doi:10.3201/eid3106.241744.
APA de Bruin, E., van Irsel, J., Chandler, F., Kohl, R., van de Voorde, T., van der Linden, A....Reusken, C. (2025). Usutu Virus Antibody Dynamics in Naturally Infected Blackbirds, the Netherlands, 2016–2018. Emerging Infectious Diseases, 31(6), 1244-1246. https://doi.org/10.3201/eid3106.241744.

Francisella tularensis Subspecies holarctica in Stranded Beluga Whales, Cook Inlet, Alaska, USA [PDF - 867 KB - 4 pages]
N. Rouse et al.

We report fatal tularemia in stranded beluga whales in Cook Inlet, Alaska, USA. Francisella tularensis was detected by nanopore metagenomics, confirmed by quantitative PCR and immunohistochemistry, and characterized as F. tularensis subspecies holarctica by multilocus sequence typing. Our findings should be considered when assessing biosecurity and marine mammal health in the North Pacific.

EID Rouse N, Buttler J, Pabilonia K, Weller C, Respicio-Kingry L, Dietrich E, et al. Francisella tularensis Subspecies holarctica in Stranded Beluga Whales, Cook Inlet, Alaska, USA. Emerg Infect Dis. 2025;31(6):1247-1250. https://doi.org/10.3201/eid3106.250033
AMA Rouse N, Buttler J, Pabilonia K, et al. Francisella tularensis Subspecies holarctica in Stranded Beluga Whales, Cook Inlet, Alaska, USA. Emerging Infectious Diseases. 2025;31(6):1247-1250. doi:10.3201/eid3106.250033.
APA Rouse, N., Buttler, J., Pabilonia, K., Weller, C., Respicio-Kingry, L., Dietrich, E....Huntington, K. (2025). Francisella tularensis Subspecies holarctica in Stranded Beluga Whales, Cook Inlet, Alaska, USA. Emerging Infectious Diseases, 31(6), 1247-1250. https://doi.org/10.3201/eid3106.250033.

Nosocomial Transmission of Plasmodium falciparum Malaria, Spain, 2024 [PDF - 1.43 MB - 4 pages]
M. Romero et al.

We report nosocomial Plasmodium falciparum malaria in Spain, which was confirmed microbiologically and genomically. Transmission occurred through insufficiently disinfected reusable syringe lead shielding during thyroid scintigraphy. Genomic analysis showed high similarity between isolates from index and source cases. Strict biosafety measures are needed in healthcare settings to prevent malaria transmission.

EID Romero M, de Pipaón M, Amuedo M, Rubio Muñoz JM, Jiménez-Hoyuela JM, Cisneros JM. Nosocomial Transmission of Plasmodium falciparum Malaria, Spain, 2024. Emerg Infect Dis. 2025;31(6):1250-1253. https://doi.org/10.3201/eid3106.241932
AMA Romero M, de Pipaón M, Amuedo M, et al. Nosocomial Transmission of Plasmodium falciparum Malaria, Spain, 2024. Emerging Infectious Diseases. 2025;31(6):1250-1253. doi:10.3201/eid3106.241932.
APA Romero, M., de Pipaón, M., Amuedo, M., Rubio Muñoz, J. M., Jiménez-Hoyuela, J. M., & Cisneros, J. M. (2025). Nosocomial Transmission of Plasmodium falciparum Malaria, Spain, 2024. Emerging Infectious Diseases, 31(6), 1250-1253. https://doi.org/10.3201/eid3106.241932.

Avian Influenza A(H5N1) Isolated from Dairy Farm Worker, Michigan, USA [PDF - 527 KB - 4 pages]
N. Brock et al.

Influenza A(H5N1) viruses have been detected in US dairy cow herds since 2024. We assessed the pathogenesis, transmission, and airborne release of A/Michigan/90/2024, an H5N1 isolate from a dairy farm worker in Michigan, in the ferret model. Results show this virus caused airborne transmission with moderate pathogenicity, including limited extrapulmonary spread, without lethality.

EID Brock N, Pulit-Penaloza JA, Belser JA, Pappas C, Sun X, Kieran TJ, et al. Avian Influenza A(H5N1) Isolated from Dairy Farm Worker, Michigan, USA. Emerg Infect Dis. 2025;31(6):1253-1256. https://doi.org/10.3201/eid3106.250386
AMA Brock N, Pulit-Penaloza JA, Belser JA, et al. Avian Influenza A(H5N1) Isolated from Dairy Farm Worker, Michigan, USA. Emerging Infectious Diseases. 2025;31(6):1253-1256. doi:10.3201/eid3106.250386.
APA Brock, N., Pulit-Penaloza, J. A., Belser, J. A., Pappas, C., Sun, X., Kieran, T. J....Maines, T. R. (2025). Avian Influenza A(H5N1) Isolated from Dairy Farm Worker, Michigan, USA. Emerging Infectious Diseases, 31(6), 1253-1256. https://doi.org/10.3201/eid3106.250386.

Aedes aegypti Mosquito Detection at Bus Stations, Bogota, Colombia, 2023–2024 [PDF - 877 KB - 2 pages]
A. Gomez et al.

We monitored mosquitoes in 3 bus stations in Bogota, Colombia, located at 2,625 m above sea level. During December 2023–January 2024, we collected 27 larvae and 1 adult female Aedes aegypti mosquitoes at 1 station. Detection of Ae. aegypti mosquitoes in Bogota is a call to continue monitoring mosquitoes at stations.

EID Gomez A, Pérez Español S, Caicedo M, Márquez Nossa A. Aedes aegypti Mosquito Detection at Bus Stations, Bogota, Colombia, 2023–2024. Emerg Infect Dis. 2025;31(6):1256-1257. https://doi.org/10.3201/eid3106.241052
AMA Gomez A, Pérez Español S, Caicedo M, et al. Aedes aegypti Mosquito Detection at Bus Stations, Bogota, Colombia, 2023–2024. Emerging Infectious Diseases. 2025;31(6):1256-1257. doi:10.3201/eid3106.241052.
APA Gomez, A., Pérez Español, S., Caicedo, M., & Márquez Nossa, A. (2025). Aedes aegypti Mosquito Detection at Bus Stations, Bogota, Colombia, 2023–2024. Emerging Infectious Diseases, 31(6), 1256-1257. https://doi.org/10.3201/eid3106.241052.

Rapid Subcutaneous Migration of Dirofilaria repens Nematode in Facial Tissue, Italy [PDF - 855 KB - 3 pages]
M. Carbonara et al.

We report a Dirofilaria repens nematode infection in a woman in Italy who sought care for a fast-creeping lesion within her subcutaneous facial tissue. Dirofilariosis should be included in differential diagnosis of subcutaneous nodules or creeping lesions. This case highlights the need for controlling canine dirofilarioses to mitigate zoonotic risk.

EID Carbonara M, Gabrielli S, Ricci A, Iatta R, Lia R, Tomassi M, et al. Rapid Subcutaneous Migration of Dirofilaria repens Nematode in Facial Tissue, Italy. Emerg Infect Dis. 2025;31(6):1258-1260. https://doi.org/10.3201/eid3106.241915
AMA Carbonara M, Gabrielli S, Ricci A, et al. Rapid Subcutaneous Migration of Dirofilaria repens Nematode in Facial Tissue, Italy. Emerging Infectious Diseases. 2025;31(6):1258-1260. doi:10.3201/eid3106.241915.
APA Carbonara, M., Gabrielli, S., Ricci, A., Iatta, R., Lia, R., Tomassi, M....Otranto, D. (2025). Rapid Subcutaneous Migration of Dirofilaria repens Nematode in Facial Tissue, Italy. Emerging Infectious Diseases, 31(6), 1258-1260. https://doi.org/10.3201/eid3106.241915.

Ehrlichia chaffeensis DNA in Haemaphysalis longicornis Ticks, Connecticut, USA [PDF - 448 KB - 3 pages]
G. Molaei et al.

Informed by passive tick surveillance, we collected questing Haemaphysalis longicornis ticks from southwestern Connecticut, USA. Of 445 ticks tested by PCR, 3 nymphs were positive: 1 for Ehrlichia chaffeensis and 2 for Borrelia burgdorferi. This finding highlights the enduring public health challenges of invasive ticks and associated pathogens.

EID Molaei G, Mohapatra A, Khalil N, Cozens D, Bonilla D. Ehrlichia chaffeensis DNA in Haemaphysalis longicornis Ticks, Connecticut, USA. Emerg Infect Dis. 2025;31(6):1260-1262. https://doi.org/10.3201/eid3106.250034
AMA Molaei G, Mohapatra A, Khalil N, et al. Ehrlichia chaffeensis DNA in Haemaphysalis longicornis Ticks, Connecticut, USA. Emerging Infectious Diseases. 2025;31(6):1260-1262. doi:10.3201/eid3106.250034.
APA Molaei, G., Mohapatra, A., Khalil, N., Cozens, D., & Bonilla, D. (2025). Ehrlichia chaffeensis DNA in Haemaphysalis longicornis Ticks, Connecticut, USA. Emerging Infectious Diseases, 31(6), 1260-1262. https://doi.org/10.3201/eid3106.250034.

Molecular Detection of Wesselsbron Virus in Dromedary Camels, Borana Zone, Ethiopia, 2024 [PDF - 1.28 MB - 3 pages]
H. Ishag et al.

We used PCR, Sanger sequencing, and phylogenetic analysis to identify Wesselsbron virus (WSLV) clade 1 in sick camels from Borana Zone, Ethiopia. Although WSLV primarily infects sheep and cattle, its pathogenicity in camels remains unclear. Camel farmers in the region should be aware of WSLV and its health effects in camels.

EID Ishag H, Tigani El Tigani-Asil E, Zawde W, Khalafalla AI, Albreiki M, Al Zarooni N, et al. Molecular Detection of Wesselsbron Virus in Dromedary Camels, Borana Zone, Ethiopia, 2024. Emerg Infect Dis. 2025;31(6):1263-1265. https://doi.org/10.3201/eid3106.250130
AMA Ishag H, Tigani El Tigani-Asil E, Zawde W, et al. Molecular Detection of Wesselsbron Virus in Dromedary Camels, Borana Zone, Ethiopia, 2024. Emerging Infectious Diseases. 2025;31(6):1263-1265. doi:10.3201/eid3106.250130.
APA Ishag, H., Tigani El Tigani-Asil, E., Zawde, W., Khalafalla, A. I., Albreiki, M., Al Zarooni, N....Mohamed, A. (2025). Molecular Detection of Wesselsbron Virus in Dromedary Camels, Borana Zone, Ethiopia, 2024. Emerging Infectious Diseases, 31(6), 1263-1265. https://doi.org/10.3201/eid3106.250130.

Baylisascaris procyonis Roundworm in Common Raccoon (Procyon lotor), Mexico [PDF - 1.42 MB - 4 pages]
A. Gómez-Sánchez et al.

We found the zoonotic nematode, Baylisascaris procyonis, in a common raccoon (Procyon lotor) in Mexico. Expansion of raccoons into human-dominated regions might increase the risk of B. procyonis infections in humans. Increased surveillance and healthcare provider awareness of baylisascariasis in Mexico will be needed to prevent those infections in humans.

EID Gómez-Sánchez A, Pinacho-Pinacho C, Barrios-Gutierrez J, Guzmán-Valdivieso I, Gonzalez-Romero A, Fonseca-Leal T, et al. Baylisascaris procyonis Roundworm in Common Raccoon (Procyon lotor), Mexico. Emerg Infect Dis. 2025;31(6):1266-1269. https://doi.org/10.3201/eid3106.241672
AMA Gómez-Sánchez A, Pinacho-Pinacho C, Barrios-Gutierrez J, et al. Baylisascaris procyonis Roundworm in Common Raccoon (Procyon lotor), Mexico. Emerging Infectious Diseases. 2025;31(6):1266-1269. doi:10.3201/eid3106.241672.
APA Gómez-Sánchez, A., Pinacho-Pinacho, C., Barrios-Gutierrez, J., Guzmán-Valdivieso, I., Gonzalez-Romero, A., Fonseca-Leal, T....López-Pérez, A. M. (2025). Baylisascaris procyonis Roundworm in Common Raccoon (Procyon lotor), Mexico. Emerging Infectious Diseases, 31(6), 1266-1269. https://doi.org/10.3201/eid3106.241672.
Letters

A Pictorial Human Case of “Furious Rabies” [PDF - 217 KB - 1 page]
C. E. Rupprecht and A. C. Jackson
EID Rupprecht CE, Jackson AC. A Pictorial Human Case of “Furious Rabies”. Emerg Infect Dis. 2025;31(6):1270. https://doi.org/10.3201/eid3106.250167
AMA Rupprecht CE, Jackson AC. A Pictorial Human Case of “Furious Rabies”. Emerging Infectious Diseases. 2025;31(6):1270. doi:10.3201/eid3106.250167.
APA Rupprecht, C. E., & Jackson, A. C. (2025). A Pictorial Human Case of “Furious Rabies”. Emerging Infectious Diseases, 31(6), 1270. https://doi.org/10.3201/eid3106.250167.
Etymologia

Eschar [esʹ kahr, esʹ kǝr] [PDF - 532 KB - 1 page]
N. Srivastava et al.
EID Srivastava N, Zaman K, Mittal M. Eschar [esʹ kahr, esʹ kǝr]. Emerg Infect Dis. 2025;31(6):1226. https://doi.org/10.3201/eid3106.240223
AMA Srivastava N, Zaman K, Mittal M. Eschar [esʹ kahr, esʹ kǝr]. Emerging Infectious Diseases. 2025;31(6):1226. doi:10.3201/eid3106.240223.
APA Srivastava, N., Zaman, K., & Mittal, M. (2025). Eschar [esʹ kahr, esʹ kǝr]. Emerging Infectious Diseases, 31(6), 1226. https://doi.org/10.3201/eid3106.240223.
About the Cover

Art of the Interwoven [PDF - 837 KB - 2 pages]
B. Breedlove
EID Breedlove B. Art of the Interwoven. Emerg Infect Dis. 2025;31(6):1271-1272. https://doi.org/10.3201/eid3106.ac3106
AMA Breedlove B. Art of the Interwoven. Emerging Infectious Diseases. 2025;31(6):1271-1272. doi:10.3201/eid3106.ac3106.
APA Breedlove, B. (2025). Art of the Interwoven. Emerging Infectious Diseases, 31(6), 1271-1272. https://doi.org/10.3201/eid3106.ac3106.
Page created: May 16, 2025
Page updated: May 29, 2025
Page reviewed: May 29, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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