We conducted a cross-sectional online anonymous survey (Appendix) through REDCap (10) during March–October 2024. We distributed the survey to HCWs eligible for ERVEBO vaccination on the basis of ACIP guidelines (5,6) at 3 Regional Emerging Special Pathogen Treatment Centers (RESPTCs): NYC Health + Hospitals/Bellevue (New York, NY, USA); University of Texas Medical Branch (Galveston, TX, USA); and Denver Health and Hospital Authority (Denver, CO, USA) (11). We selected those survey sites because they were planning to offer ERVEBO vaccine to eligible staff. The study was approved by the New York University Grossman School of Medicine Institutional Review Board (approval no. i23-00730). We conducted recruitment through email communications (68%) and in-person invitations during optional vaccine education sessions (32%). The cohort we labeled as “interested in receiving vaccine” was made up of respondents who indicated they were already vaccinated or would definitely or probably choose to be vaccinated. The cohort we labeled as “not interested in receiving vaccine or unsure” was made up of respondents who indicated they would definitely or probably not choose to be vaccinated or were unsure. We compared characteristics of the 2 cohorts by using a χ² test and considered a p value <0.05 significant.

There were 66 respondents (37% response rate). The largest age group was 30–49 years of age (64%); 63.6% were female and 36.4% male (Table 1). Occupations represented included physicians (42%), nurses (27%), clinical laboratory professionals (24%), emergency medical technicians (5%), and research laboratory professionals (2%). The most represented hospital departments were critical care medicine (27%), hospital medicine (11%), infectious diseases (11%), and pediatric critical care (11%). More than half of participants (56%) had received some form of education on Ebola vaccines, most commonly through informational sheets or pamphlets (33%) or self-study of primary literature or public health guidelines (20%).

Figure

Figure. Survey responses from study of healthcare worker attitudes and perceptions toward the Ebola vaccine, United States, 2024. A) Interest in receiving ERVEBO vaccine (Merck, https://www.merck.com) among eligible healthcare...

Thirty-four respondents (51%) were interested in receiving the vaccine, with a subset of respondents already vaccinated (n = 4) at the time of the survey (Figure, panel A). Among respondents interested and not already vaccinated, 27% would plan to get vaccinated when an EVD case appeared in the United States or their state or region (Figure, panel B).

Among those respondents unsure about or not interested in receiving the vaccine (n = 32), some reported they might be convinced to vaccinate if there were an EVD outbreak in the United States (44%); if they better understood the risks and benefits of vaccination (34%), vaccine safety (31%), or the risk of spreading VSV to others (28%); and if there were an Ebola virus vaccine using a different vaccine technology (19%). In this cohort, the most common reasons for not wanting to receive ERVEBO vaccination or being unsure of their decision included concerns about spreading VSV to others (44%), feeling that the risks of vaccine side effects are not acceptable (31%), not personally knowing enough about the vaccine to make a decision (31%), and not thinking there will be an EVD outbreak in the United States (28%).

Among all respondents, the most common concerns regarding side effects were the potential for serious side effects that lasted a long time or interfered with daily life (62%), the potential increased risk of spreading VSV to others (47%), and the potential increased risk for arthritis (36%). Many respondents expressed desire to learn more about ERVEBO (Table 2). The most selected educational topics of interest included the likelihood and nature of side effects from vaccination (67%), the likelihood and severity of spreading VSV to others (59%), and what their individual risk of getting EVD was (26%).

In 2022, ACIP expanded their occupational exposure to include laboratory workers within the Laboratory Response Network and staff at SPTCs. They conducted a knowledge, attitudes, and practices survey in October 2020, during an EVD outbreak in the Democratic Republic of the Congo (6). Among SPTCs, 54% of respondents reported willingness to be vaccinated. Vaccine willingness increased to 81% if they were given the choice of vaccination timing. Those responses are consistent with our findings that many HCWs interested in ERVEBO vaccination would prefer to wait until an EVD case is imported to the United States. However, the SPTC survey did not report on specific areas of interest for more education or what factors might influence currently uninterested HCWs to get vaccinated in the future.

Surveys conducted in the Democratic Republic of the Congo (12) and Uganda (13) indicated a strong interest among HCWs to receive an Ebola vaccine. However, those data might not be generalizable to HCWs in the United States because the risk for exposure to Ebola virus is lower. A survey in 2015 during the height of the 2014–2016 Ebola outbreak in West Africa found that only 34% of the US population were interested in receiving an Ebola vaccine (14). This survey did not specifically assess HCW interest, and it was performed before the US Food and Drug Administration licensure of ERVEBO.

During a period with no EVD outbreaks, 48% (30/62) of eligible unvaccinated HCWs surveyed at 3 US RESPTCs were interested in receiving the ERVEBO Ebola vaccine. Of those interested and not already vaccinated, 27% preferred to postpone vaccination until there is a case of EVD in the United States or their state or region.

One limitation of this study is that only 3 RESPTCs were surveyed, so their attitudes might not be representative of all US HCWs eligible for ERVEBO vaccination. Second, the sample size is too small to analyze for differences between subgroups of respondents. However, we did achieve a 37% survey response rate from a cohort of workers who are most likely to provide ongoing direct care to patients with EVD that require care in the United States.

Deployment of ERVEBO vaccine to eligible HCWs in the United States might be optimized by addressing respondent concerns. Those concerns include improving education on the risks and benefits of ERVEBO vaccination, vaccine safety, and risk of vaccine viral vector transmission.