Early Release

Supplement

• Long-Term Illness in Adults Hospitalized for Respiratory Syncytial Virus Disease, United States, February 2022–September 2023
  A. M. Leis et al.
• Nonspecific Symptoms Attributable to Lyme Disease in High-Incidence Areas, United States, 2017–2021
  C. C. Nawrocki et al. View Abstract

  For some patients who have Lyme disease (LD), nonspecific symptoms can persist after treatment and impair quality of life. Estimating the frequency and duration of such symptoms is challenging. Using commercial insurance claims data from 2017–2021 for enrollees residing in states where LD is common, we identified 24,503 case-patients with LD and matched them (1:5) with 122,095 control-patients with other diagnoses by demographics, medical service date, and inpatient/outpatient setting. We compared relative frequencies of diagnosis codes for pain, fatigue, and cognitive difficulties between case-patients and control-patients in the year after diagnosis. Those symptom codes occurred 5.0% more frequently among case-patients than among control-patients and comprised »11.0% of the total symptom codes among case-patients. Symptom code frequency among case-patients declined significantly in the 6–12 months after LD diagnosis and reached levels similar to control-patients by the end of the year, with the exception of fatigue.

• Progress Toward Understanding Infection-Associated Chronic Conditions and Illnesses
  A. E. Fiore
• Persistence of Symptoms among Commercially Insured Patients with Coccidioidomycosis, United States, 2017–2023
  I. Hennessee et al. View Abstract

  Some patients with coccidioidomycosis experience prolonged respiratory and systemic symptoms. However, data on prevalence and persistence of most symptoms are lacking. Using an insurance claims database, we identified patients with coccidioidomycosis diagnoses in the United States during 2017–2023. We assessed prevalence of associated symptoms from 6 months before to 1 year after first diagnosis code (index date) and compared post–index date prevalence to baseline (within 6 to 4 months before index date). Among 2,640 patients, cough (20.8%), dyspnea (13.0%), and fatigue (8.8%) were the most common symptoms at index date. Dyspnea and erythema nodosum were elevated 3–6 months post–index date (p<0.03), and fatigue, headache, joint pain, and weakness were elevated 9–12 months post–index date compared with baseline (p<0.05).These findings demonstrate that symptoms can persist in coccidioidomycosis patients, which could help inform clinical management and refine estimates of the health and economic burden of coccidioidomycosis.

Synopses

• Haematospirillum jordaniae Infections after Recreational Exposure to River Water, Pennsylvania, USA, 2020
  M. Dulcey et al.
• Trichosporon austroamericanum Infections among Hospitalized Patients, France, 2022–2024
  E. Burel et al.
• Two Concurrent Outbreaks of Listeria monocytogenes Infections Linked to Packaged Salads, 2014–2022
  A. Palacios et al.

Research

• Pregnancy Outcomes after Exposure to Tuberculosis Treatment in Phase 3 Clinical Trial, 2016–2020
  E. V. Kurbatova et al.
• Independent Acquisitions of Multidrug Resistance Gene lsaC in Serotype 20 Sequence Type 1257 Streptococcus pneumoniae Isolates
  B. Beall et al.
• Performance of Community Driven Text Message-Based Surveillance System During COVID-19 Pandemic, Los Angeles County, California, USA, 2020–2024
  J. B. Braunfeld et al.
• Isolation and Characterization of Rickettsia finnyi, Novel Pathogenic Spotted Fever Group Rickettsia in Dogs, United States
  P. K. Korla et al.
• Tickborne Neoehrlichia mikurensis in the Blood of Blood Donors, Norway, 2023
  H. Quarsten et al. View Abstract

  The tickborne bacterial pathogen Neoehrlichia mikurensis has been detected in <1% of blood donors in Sweden. N. mikurensis can give rise to asymptomatic persistent infections. Up to 25% of Ixodes ricinus ticks in southern Norway are infected with N. mikurensis. We investigated the incidence of N. mikurensis infection among blood donors in this region. We detected N. mikurensis in the blood of 45/499 (9%) blood donors by independent PCR methods; 69% of those were repeatedly positive 1–7 months after the first detection and tested negative after doxycycline treatment. We tested 8/19 adult recipients of potentially infected blood; none tested positive for N. mikurensis at the time of testing (191–301 days after transfusion). Our study identified a very high rate of infection with N. mikurensis in blood donors in Norway; whether infection can be transmitted by transfusion of blood products, however, remains unclear.

Dispatches

• Borrelia afzelii Hepatitis in Patient Treated with Venetoclax and Obinutuzumab, Switzerland
  G. Capoferri et al.
• A Prospective Multicenter Study of Neoehrlichia mikurensis in Ticks and Tick-Bitten Individuals in Sweden and Finland, 2008-2009
  E. Hero et al.
• Two Autochthonous Cases of Anaplasmosis, Washington State, USA, 2022–2023
  H. Schnitzler et al.
• Bjerkandera Species Pulmonary Infection in Immunocompromised Hosts, Germany
  R. Sprute et al.
• Novel Dolphin Tupavirus from Stranded Atlantic White-Sided Dolphin, Canada
  O. Vernygora et al.
• Healthcare Worker Attitudes and Perceptions toward Ebola Vaccine, United States, 2024
  R. Goswami et al.
• Shifting Dynamics of Dengue Virus Serotype DENV-2 and Emergence of Cosmopolitan Genotype, Costa Rica, 2024
  M. González-Elizondo et al.

Research Letters

• Two Cases of Autochthonous West Nile Virus Encephalitis, Paris, France, 2025
  N. Hassold-Rugolino et al. View Abstract

  We report 2 cases of febrile lymphocytic meningitis with encephalitis in patients in France. One patient had not traveled outside Paris; the other had traveled to eastern France. Laboratory findings revealed acute West Nile virus infection. The cases occurred days apart, raising concern the virus has spread further in France.

• Molecular Evidence of Dengue Virus Type 2 Emergence from Returning Travelers, Sinai Peninsula
  N. S. Zuckerman et al.
• Human Infection with Avian Influenza A(H10N3) Virus, China, 2024
  J. Wang et al. View Abstract

  We describe the clinical symptoms and epidemiologic characteristics of a patient infected with avian influenza A(H10N3) virus in Guangxi Province, China, in December 2024. Whole-genome sequencing showed that the virus was highly homologous to a virus from Yunnan Province. H10 subtype viruses should be monitored for potential zoonotic or reassortant events.

• Extensively Drug-Resistant Tuberculosis with Conflicting Resistance Testing Results, Lesotho
  K. J. Seung et al.
• Emergence of Dengue Virus Serotype 3, Lineage III_B.3.2, Angola
  J. de Vasconcelos et al.
• Fatal Tickborne Encephalitis in Unvaccinated Traveler, Switzerland, 2022
  C. Scotti et al.
• Orientia among Patients with Eschars and Suspected Tickborne Disease, North Carolina, 2020–2022
  H. A. Abernathy et al.
• Yellow Fever Virus in Aedes albopictus from an Urban Green Area in São Paulo State, Brazil
  E. S. Bergo et al.
• Crimean-Congo Hemorrhagic Fever Virus in Cattle and Ticks, Israel
  N. Rudoler et al.
• Mortality Event in Rainbow Snakes Linked to Snake Fungal Disease, United States
  D. A. Conley et al.

Online Report

• Diphtheria Antitoxin Production and Procurement Practices and Challenges
  C. Marshall et al.

Research

• Group A Streptococcus Meningitis, United States, 1997–2022
  P. A. Hawkins et al.