Lyme Disease Spotlight
Lyme disease is caused by the bacterium Borrelia burgdorferi and rarely, Borrelia mayonii,, which is transmitted to humans through the bite of infected Ixodes ticks. Typical symptoms of Lyme disease include fever, headache, fatigue, and a characteristic skin rash. If left untreated, infection can spread to joints, the heart, and the nervous system. Most cases of Lyme disease can be treated successfully with a few weeks of antibiotics.
In the United States, recent studies suggest that approximately 476,000 people are diagnosed with Lyme disease each year. Steps to prevent Lyme disease include using insect repellent, removing ticks promptly, applying pesticides, and reducing tick habitat.
2024
Computerized Decision Support Systems Informing Community-Acquired Pneumonia Surveillance, France, 2017–2023Tristan Delory et al. Volume 30, Number 11—November 2024 Age- and Sex-Specific Differences in Lyme Disease Health-Related Behaviors, Ontario, Canada, 2015–2022
Janica A. Adams et al. Volume 30, Number 10—October 2024 Rapid Increase in Seroprevalence of Borrelia burgdorferi Antibodies among Dogs, Northwestern North Carolina, USA, 2017–2021
Peyton K. Pretsch et al. Volume 30, Number 10—October 2024 Epidemiology of Lyme Disease Diagnoses among Older Adults, United States, 2016–2019
Amy M. Schwartz et al. Volume 30, Number 9—September 2024 Electronic Health Record Data for Lyme Disease Surveillance, Massachusetts, USA, 2017–2018
Kshema Nagavedu et al. Volume 30, Number 7—July 2024 Delayed Diagnosis of Locally Acquired Lyme Disease, Central North Carolina, USA
Ross M. Boyce et al. Volume 30, Number 3—March 2024 Acute Gastroenteritis Associated with Norovirus GII.8[P8], Thailand, 2023
Watchaporn Chuchaona et al. Volume 30, Number 1—January 2024
2023
Investigation of Possible Link between Interferon-α and Lyme DiseaseArmin Alaedini et al. Volume 29, Number 11—November 2023 Erythema Migrans Caused by Borrelia spielmanii, France
Pascal del Giudice et al. Volume 29, Number 11—November 2023 Cycle Threshold Values as Indication of Increasing SARS-CoV-2 New Variants, England, 2020–2022
Rebecca E. Harrison et al. Volume 29, Number 10—October 2023 Borrelia bavariensis in Questing Ixodes ricinus Ticks, United Kingdom
Grace Plahe et al. Volume 29, Number 10—October 2023 Treponema pallidum Detection at Asymptomatic Oral, Anal, and Vaginal Sites in Adults Reporting Sexual Contact with Persons with Syphilis
Ei T. Aung et al. Volume 29, Number 10—October 2023 Validation of Claims-Based Algorithm for Lyme Disease, Massachusetts, USA
Noelle M. Cocoros et al. Volume 29, Number 9—September 2023 Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood
Sergio A. Hernández et al. Volume 29, Number 6—June 2023 Bartonella spp. Infections Identified by Molecular Methods, United States
David W. McCormick et al. Volume 29, Number 3—March 2023 Genomic Confirmation of Borrelia garinii, United States
Natalie Rudenko et al. Volume 29, Number 1—January 2023 Up Close with Ticks
Byron Breedlove Volume 29, Number 1—January 2023
2022
Systematic Review and Meta-analysis of Lyme Disease Data and Seropositivity for Borrelia burgdorferi, China, 2005‒2020James H. Stark et al. Volume 28, Number 12—December 2022 Podcast Economic Burden of Reported Lyme Disease in High-Incidence Areas, United States, 2014–2016
Sarah A. Hook et al. Volume 28, Number 6—June 2022
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Podcast
Effects of Tick-Control Interventions on Tick Abundance, Human Encounters with Ticks, and Incidence of Tickborne Diseases in Residential Neighborhoods, New York, USA
Felicia Keesing et al. Volume 28, Number 5—May 2022
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Unique Clinical, Immune, and Genetic Signature in Patients with Borrelial Meningoradiculoneuritis
Katarina Ogrinc et al. Volume 28, Number 4—April 2022 Deadly, Dangerous, and Decorative Creatures
Byron Breedlove Volume 28, Number 2—February 2022
2021
Effects of COVID-19 Pandemic on Reported Lyme Disease, United States, 2020David W. McCormick et al. Volume 27, Number 10—October 2021 Podcast Comparison of Lyme Disease in the United States and Europe
Adriana R. Marques et al. Volume 27, Number 8—August 2021
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COVID-19 and the Consequences of Anchoring Bias
Harold W. Horowitz et al. Volume 27, Number 8—August 2021 Podcast Infections with Tickborne Pathogens after Tick Bite, Austria, 2015–2018
Mateusz Markowicz et al. Volume 27, Number 4—April 2021
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Use of Commercial Claims Data for Evaluating Trends in Lyme Disease Diagnoses, United States, 2010–2018
Amy M. Schwartz et al. Volume 27, Number 2—February 2021 Borrelia burgdorferi Sensu Stricto DNA in Field-Collected Haemaphysalis longicornis Ticks, Pennsylvania, United States
Keith J. Price et al. Volume 27, Number 2—February 2021 Podcast Estimating the Frequency of Lyme Disease Diagnoses, United States, 2010–2018
Kiersten J. Kugeler et al. Volume 27, Number 2—February 2021
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Podcast
Emergence of Lyme Disease on Treeless Islands, Scotland, United Kingdom
Caroline Millins et al. Volume 27, Number 2—February 2021
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2020
Pediatric Lyme Disease Biobank, United States, 2015–2020Lise E. Nigrovic et al. Volume 26, Number 12—December 2020 Lyme Borreliosis with Scalp Eschar Mimicking Rickettsial Infection, Austria
Mateusz Markowicz et al. Volume 26, Number 9—September 2020 Risk Factors for and Seroprevalence of Tickborne Zoonotic Diseases among Livestock Owners, Kazakhstan
Jennifer R. Head et al. Volume 26, Number 1—January 2020
2019
Rodent Host Abundance and Climate Variability as Predictors of Tickborne Disease Risk 1 Year in AdvanceEmil Tkadlec et al. Volume 25, Number 9—September 2019 Podcast Enhancement of Risk for Lyme Disease by Landscape Connectivity, New York, New York, USA
Meredith C. VanAcker et al. Volume 25, Number 6—June 2019
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Co-infections in Persons with Early Lyme Disease, New York, USA
Gary P. Wormser et al. Volume 25, Number 4—April 2019 Lyme Disease Emergence after Invasion of the Blacklegged Tick, Ixodes scapularis, Ontario, Canada, 2010–2016
Manisha A. Kulkarni et al. Volume 25, Number 2—February 2019
2018
Increasing Prevalence of Borrelia burgdorferi sensu stricto–Infected Blacklegged Ticks in Tennessee Valley, Tennessee, USAGraham J. Hickling et al. Volume 24, Number 9—September 2018 Borrelia miyamotoi sensu lato in Père David Deer and Haemaphysalis longicornis Ticks
Yi Yang et al. Volume 24, Number 5—May 2018 Dynamics of Spirochetemia and Early PCR Detection of Borrelia miyamotoi
Lyudmila Karan et al. Volume 24, Number 5—May 2018 Relative Risk for Ehrlichiosis and Lyme Disease Where Vectors for Both Are Sympatric, Southeastern United States
Marcia E. Herman-Giddens Volume 24, Number 2—February 2018
2017
Serologic Evidence of Powassan Virus Infection in Patients with Suspected Lyme DiseaseHolly M. Frost et al. Volume 23, Number 8—August 2017 Lyme Borreliosis in Finland, 1995–2014
Eeva Sajanti et al. Volume 23, Number 8—August 2017 Podcast Relative Risk for Ehrlichiosis and Lyme Disease in an Area Where Vectors for Both Are Sympatric, New Jersey, USA
Andrea Egizi et al. Volume 23, Number 6—June 2017
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Use of Mass-Participation Outdoor Events to Assess Human Exposure to Tickborne Pathogens
Jessica L. Hall et al. Volume 23, Number 3—March 2017
2016
PandemicJennifer B. Nuzzo Volume 22, Number 10—October 2016 Borrelia miyamotoi–Associated Neuroborreliosis in Immunocompromised Person
Katharina Boden et al. Volume 22, Number 9—September 2016 Current Guidelines, Common Clinical Pitfalls, and Future Directions for Laboratory Diagnosis of Lyme Disease, United States
Andrew Moore et al. Volume 22, Number 7—July 2016 Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States
Tjasa Cerar et al. Volume 22, Number 5—May 2016 Lyme Disease in Hispanics, United States, 2000–2013
Christina A. Nelson et al. Volume 22, Number 3—March 2016
2015
No Geographic Correlation between Lyme Disease and Death Due to 4 Neurodegenerative Disorders, United States, 2001–2010Joseph D. Forrester et al. Volume 21, Number 11—November 2015 Epidemiology of Lyme Disease, Nova Scotia, Canada, 2002–2013
Todd F. Hatchette et al. Volume 21, Number 10—October 2015 Enhancing Lyme Disease Surveillance by Using Administrative Claims Data, Tennessee, USA
Joshua L. Clayton et al. Volume 21, Number 9—September 2015 Incidence of Clinician-Diagnosed Lyme Disease, United States, 2005–2010
Christina A. Nelson et al. Volume 21, Number 9—September 2015 TickNET—A Collaborative Public Health Approach to Tickborne Disease Surveillance and Research
Paul S. Mead et al. Volume 21, Number 9—September 2015 Geographic Distribution and Expansion of Human Lyme Disease, United States
Kiersten J. Kugeler et al. Volume 21, Number 8—August 2015 Oligoarthritis Caused by Borrelia bavariensis, Austria, 2014
Mateusz Markowicz et al. Volume 21, Number 6—June 2015 Antibodies against Borrelia burgdorferi sensu lato among Adults, Germany, 2008–2011
Hendrik Wilking et al. Volume 21, Number 1—January 2015
2014
Molecular Characterization of Borrelia burgdorferi from Case of Autochthonous Lyme ArthritisSharon I. Brummitt et al. Volume 20, Number 12—December 2014 Borrelia garinii and Rickettsia monacensis in Ixodes ricinus Ticks, Algeria
Wassila Benredjem et al. Volume 20, Number 10—October 2014 Lyme Disease, Virginia, USA, 2000–2011
R. Jory Brinkerhoff et al. Volume 20, Number 10—October 2014 Human Infections with Borrelia miyamotoi, Japan
Kozue Sato et al. Volume 20, Number 8—August 2014 Human Exposure to Tickborne Relapsing Fever Spirochete Borrelia miyamotoi, the Netherlands
Manoj Fonville et al. Volume 20, Number 7—July 2014 Borrelia miyamotoi sensu lato Seroreactivity and Seroprevalence in the Northeastern United States
Peter J. Krause et al. Volume 20, Number 7—July 2014 Tick-borne Pathogens in Northwestern California, USA
Daniel J. Salkeld et al. Volume 20, Number 3—March 2014 Monitoring Human Babesiosis Emergence through Vector Surveillance New England, USA
Maria A. Diuk-Wasser et al. Volume 20, Number 2—February 2014
2013
Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USAMarc Y. El Khoury et al. Volume 19, Number 12—December 2013 Atypical Erythema Migrans in Patients with PCR-Positive Lyme Disease
Steven E. Schutzer et al. Volume 19, Number 5—May 2013 Borrelia crocidurae Meningoencephalitis, West Africa
Sandrine Goutier et al. Volume 19, Number 2—February 2013
2012
Bartonella spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic RegionC. Ben Beard et al. Volume 18, Number 11—November 2012 Bartonella spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic Region
Ricardo G. Maggi et al. Volume 18, Number 11—November 2012 Bartonella spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic Region
Ricardo G. Maggi et al. Volume 18, Number 5—May 2012 Effect of Surveillance Method on Reported Characteristics of Lyme Disease, Connecticut, 1996–2007
Starr-Hope Ertel et al. Volume 18, Number 2—February 2012
2011
Differential Risk for Lyme Disease along Hiking Trail, GermanyDania Richter et al. Volume 17, Number 9—September 2011 Canine Serology as Adjunct to Human Lyme Disease Surveillance
Paul S. Mead et al. Volume 17, Number 9—September 2011 Multitarget Test for Emerging Lyme Disease and Anaplasmosis in a Serosurvey of Dogs, Maine, USA
Peter W. Rand et al. Volume 17, Number 5—May 2011
2010
Erythema Migrans–like Illness among Caribbean IslandersAnu Sharma et al. Volume 16, Number 10—October 2010 Geographic Differences in Genetic Locus Linkages for Borrelia burgdorferi
Bridgit Travinsky et al. Volume 16, Number 7—July 2010 Evolution of Northeastern and Midwestern Borrelia burgdorferi, United States
Dustin Brisson et al. Volume 16, Number 6—June 2010 Bartonella spp. Transmission by Ticks Not Established
Sam R. Telford et al. Volume 16, Number 3—March 2010
2009
Correlation between Tick Density and Pathogen Endemicity, New HampshireSeth T. Walk et al. Volume 15, Number 4—April 2009
2008
Wide Distribution of a High-Virulence Borrelia burgdorferi Clone in Europe and North AmericaWei-Gang Qiu et al. Volume 14, Number 7—July 2008 Effectiveness of Personal Protective Measures to Prevent Lyme Disease
Marietta Vázquez et al. Volume 14, Number 2—February 2008
2007
Lyme Disease in Urban Areas, ChicagoDean A. Jobe et al. Volume 13, Number 11—November 2007 Borrelia burgdorferi Infection and Cutaneous Lyme Disease, Mexico
Guadalupe Gordillo-Pérez et al. Volume 13, Number 10—October 2007 Zoonotic Pathogens in Ixodes scapularis, Michigan
Sarah A. Hamer et al. Volume 13, Number 7—July 2007 Human Babesia microti Incidence and Ixodes scapularis Distribution, Rhode Island, 1998–2004
Sarah E. Rodgers et al. Volume 13, Number 4—April 2007
2006
Modulatory Effect of Cattle on Risk for Lyme DiseaseDania Richter et al. Volume 12, Number 12—December 2006 Borrelia lusitaniae and Green Lizards (Lacerta viridis), Karst Region, Slovakia
Viktória Majláthová et al. Volume 12, Number 12—December 2006 Migratory Passerine Birds as Reservoirs of Lyme Borreliosis in Europe
Pär Comstedt et al. Volume 12, Number 7—July 2006 Lyme Borreliosis and Borrelia spielmanii
Vera Maraspin et al. Volume 12, Number 7—July 2006 Borrelia burgdorferi in Ixodes scapularis Ticks, Chicago Area
Dean A. Jobe et al. Volume 12, Number 6—June 2006 Epidemic Spread of Lyme Borreliosis, Northeastern United States
Klára Hanincová et al. Volume 12, Number 4—April 2006 Economic Impact of Lyme Disease
Xinzhi Zhang et al. Volume 12, Number 4—April 2006
2005
Third Borrelia Species in White-footed MiceJonas Bunikis et al. Volume 11, Number 7—July 2005 Antibody Testing and Lyme Disease Risk
Elizabeth G. Stone et al. Volume 11, Number 5—May 2005 Hypersensitivity to Ticks and Lyme Disease Risk
Georgine Burke et al. Volume 11, Number 1—January 2005
2004
Typing of Borrelia Relapsing Fever Group StrainsJonas Bunikis et al. Volume 10, Number 9—September 2004 Do Antiborrelial Antibodies Suggest Lyme Disease in Cuba?
Islay Rodríguez et al. Volume 10, Number 9—September 2004 Anaplasma phagocytophilum, Babesia microti, and Borrelia burgdorferi in Ixodes scapularis, Southern Coastal Maine
Mary S. Holman et al. Volume 10, Number 4—April 2004
2003
Relapsing Fever–Like Spirochetes Infecting European Vector Tick of Lyme Disease AgentDania Richter et al. Volume 9, Number 6—June 2003
2002
Co-feeding Transmission and Its Contribution to the Perpetuation of the Lyme Disease Spirochete Borrelia afzeliiDania Richter et al. Volume 8, Number 12—December 2002 Evaluation and Validation of a Real-Time Polymerase Chain Reaction Assay for Rapid Identification of Bacillus anthracis
Alex R. Hoffmaster et al. Volume 8, Number 10—October 2002 Mapping Lyme Disease Incidence for Diagnostic and Preventive Decisions, Maryland
Christina Frank et al. Volume 8, Number 4—April 2002 Predicting the Risk of Lyme Disease: Habitat Suitability for Ixodes scapularis in the North Central United States
Marta Guerra et al. Volume 8, Number 3—March 2002 Vector Interactions and Molecular Adaptations of Lyme Disease and Relapsing Fever Spirochetes Associated with Transmission by Ticks
Tom G. Schwan et al. Volume 8, Number 2—February 2002
2001
Borrelia lonestari DNA in Adult Amblyomma americanum Ticks, AlabamaThomas R. Burkot et al. Volume 7, Number 3—June 2001
2000
Lyme Disease Surveillance in England and Wales, 1986-1998Robert Smith et al. Volume 6, Number 4—August 2000 First Report of Human Granulocytic Ehrlichiosis from Southern Europe (Spain)
José A. Oteo et al. Volume 6, Number 4—August 2000 Borrelia burgdorferi and the Causative Agent of Human Granulocytic Ehrlichiosis in Deer Ticks, Delaware
Kathleen L. Curran et al. Volume 6, Number 4—August 2000 The bdr Gene Families of the Lyme Disease and Relapsing Fever Spirochetes: Potential Influence on Biology, Pathogenesis, and Evolution
David M. Roberts et al. Volume 6, Number 2—April 2000 Competence of American Robins as Reservoir Hosts for Lyme Disease Spirochetes
Dania Richter et al. Volume 6, Number 2—April 2000
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
