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Volume 20, Number 2—February 2014
Research

Lymphocytic Choriomeningitis Virus in Employees and Mice at Multipremises Feeder-Rodent Operation, United States, 2012

Barbara KnustComments to Author , Ute Ströher, Laura Edison, César G. Albariño, Jodi Lovejoy, Emilian Armeanu, Jennifer House, Denise Cory, Clayton Horton, Kathy L. Fowler, Jessica Austin, John Poe, Kraig E. Humbaugh, Lisa Guerrero, Shelley Campbell, Aridth Gibbons, Zachary Reed, Deborah Cannon, Craig Manning, Brett Petersen, Douglas Metcalf, Bret Marsh, Stuart T. Nichol, and Pierre E. Rollin
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (B. Knust, U. Ströher, L. Edison, C.G. Albarino, L. Guerrero, S. Campbell, A. Gibbons, Z. Reed, D. Cannon, C. Manning, B. Petersen, S.T. Nichol, P.E. Rollin); Georgia Department of Public Health, Atlanta (L. Edison); Indiana Board of Animal Health, Indianapolis, Indiana, USA (J. Lovejoy, D. Metcalf, B. Marsh); Deaconess Hospital, Evansville, Indiana, USA (E. Armeanu); Indiana State Department of Health, Indianapolis (J. House); Vanderburgh County Health Department, Evansville (D. Cory); Green River District Health Department, Owensboro, Kentucky, USA (C. Horton, J. Austin); Kentucky Department for Public Health, Frankfort, Kentucky, USA (K.L. Fowler, J. Poe, K.E. Humbaugh)

Main Article

Table 3

Exposures of employees at facilities A, B, and C and comparison with LCMV ELISA test results, Indiana, USA, 2012*

Facility A Facility B‡ Facility C‡
Positive, n = 15§
 Negative, n = 37
 OR (95% CI)
 χ2 p value
Positive, n = 1
 Negative, n = 12
 χ2 p value
Positive, n = 15
 Negative, n = 17
 OR (95% CI)
 χ2 p value
Work
With mice 13 (87) 28 (78) 1.86 (0.35–10.0) 0.47
With rats 5 (33) 14 (39) 0.79 (0.22–2.79) 0.71
Building
1 4 (27) 8 (23) 1.22 (0.31–4.93) 0.77
2 12 (80) 14 (40) 6.0 (1.43–25.19) 0.01
3 9 (60) 21 (60) 1.0 (0.29–3.44) 1.0
4 9 (60) 20 (57) 1.12 (0.33–3.85) 0.85
Personal protection
Wash hands 15 (100) 37 (100) ND ND 1 (100) 12 (100) ND 15 (100) 17 (100) ND ND
Wear gloves 15 (100) 37 (100) ND ND 1 (100 12 (100) ND 14 (93) 15 (88) 1.87 (0.15–22.9) 0.62
Wear mask 10 (77) 23 (72) 1.30 (0.29–5.86) 0.73 1 (100) 9 (75) 0.9¶ 6 (40) 12 (71) 0.28 (0.06–1.21) 0.08
Smoke 11 (73) 15 (42) 3.85 (1.02–14.45) 0.04 1 (100) 1 (8) 0.18¶ 3 (21) 5 (29) 0.65 (0.13–3.4) 0.47
Sex, M
 10 (66)
 32 (87)
 0.31 (0.07–1.3)
 0.21
0
 9 (75)
 0.31¶
10 (66)
 10 (58)
 1.4 (0.32–6.1)
 0.21
Mean time employed, y 0.82 0.84 0.96 6 7.17 0.87 1.86 3.89 0.07
Mean age, y 33.93 36.7 0.46 38 30.75 0.54 32.33 36.76 0.18

*LCMV, lymphocytic choriomeningitis virus; OR, odds ratio. ND, not determined. Boldface indicates significant values (p<0.05).
†All values are no. (%) employees who responded to the questionnaire unless otherwise indicated.
‡Housed only mice. Employees were not asked about exposures to different facility buildings, so these factors were not evaluated (blank cells).
§Patients were ELISA-positive if a serum sample had detectable LCMV IgG or IgM.
¶Because of low numbers, a Fisher exact test was used to calculate p values, except for mean time employed and mean age, for which a t test was used.

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Page created: January 17, 2014
Page updated: January 17, 2014
Page reviewed: January 17, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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