Volume 20, Number 5—May 2014
Dispatch
Shigella spp. with Reduced Azithromycin Susceptibility, Quebec, Canada, 2012–2013
Table 2
Characteristics and antimicrobial susceptibility of 4 Shigella isolates with reduced azithromycin susceptibility, Montreal, Quebec, Canada, January 2012–April 2013*
Shigella species | ST | PV† | AZM, mg/L‡ | AMP, mg/L | TMP/SMX, mg/L | CIP mg/L | CRO, mg/L | TET, mg/L | CHL, mg/L | NAL mm |
---|---|---|---|---|---|---|---|---|---|---|
S. flexneri | 2a | 15 | 256 | <2 (S) | >320 (R) | 0.016 | <1 | >128 | 0.5 (S) | 27 |
S. flexneri | 2a | 16 | 64 | >32 (R) | >320 (R) | 0.016 | <1 | >128 | 128 (R) | 27 |
S. flexneri | 3a | 6 | >256 | >32 (R) | <20 (S) | 0.016 | <1 | >128 | >256 (R) | 24–28 |
S. sonnei | – | 101,105§ | >256 | >32 (R) | >320 (R) | 0.016 | <1 | >128 | >256 (R) | 23–27 |
*The susceptibility and resistance break points for AMP, CIP, TMP/SMX, CRO, TET, CHL, and NAL were Clinical and Laboratory Standards Institute Enterobacteriaceae break points (12). ST, serotype; PV, pulsovar; AZM, azithromycin; AMP, ampicillin; TMP/SMX, trimethoprim/sulfamethoxazole; CIP, ciprofloxacin; CRO, ceftriaxone; TET, tetracycline; CHL, chloramphenicol; NAL, nalidixic acid; S, susceptible; R: resistant; –, not applicable.
†PV was determined by XbaI and BlnI pulsed-field gel electrophoresis patterns.
‡The criterion for elevated azithro MIC was >16 mg/L (13).
§S. sonnei PVs 101 and 105 were related and had 2 different pulsed-field gel electrophoresis bands.
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