Respiratory Infection with Enterovirus Genotype C117, China and Mongolia
Zichun Xiang
1, Sosorbaramyn Tsatsral
1, Chunyan Liu
1, Linlin Li, Lili Ren, Yan Xiao, Zhengde Xie, Hongli Zhou, Guy Vernet, Pagbajabyn Nymadawa, Kunling Shen, and Jianwei Wang
Author affiliations: MOH Key Laboratory of Systems Biology of Pathogens, Beijing, China; (Z. Xiang, L. Li, L. Ren, J. Wang); Institute of Pathogen Biology, Beijing (Z. Xiang, L. Li, L. Ren, Y. Xiao, H. Zhou, J. Wang); National Center of Communicable Diseases, Ulaanbaatar, Mongolia (S. Tsatsral, P. Nymadawa); Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing (C. Liu, Z. Xie, K. Shen); Fondation Mérieux, 69365 Lyon, France (G. Vernet); Mongolian Academy of Medical Sciences, Ulaanbaatar (P. Nymadawa)
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Figure
Figure. Phylogenetic analysis of enterovirus genotype C117 (EV-C117) based on nucleotide sequencesPhylogenetic trees were generated with 1,000 bootstrap replicatesNeighbor-joining analysis of the targeted nucleotide sequence was performed by using the Kimura 2-parameter model with Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0 (http://www.megasoftware.net)The EV-C117 strains identified in this study are indicated by black circlesEnterovirus 68, cocksackievirus (CV) A2, and echovirus (E) 3 (GenBank accession nosAY426531, AY421760, and AY302553) were used as outgroupsPV, poliovirusA) Phylogenetic analysis of the VP 4/VP2 region (399 nt, corresponding to nt 673–1,071 of EV-C117 prototype strain LIT22 [JX262382])B) Phylogenetic analysis of the viral protein1 region (888 nt, corresponding to nt 2416–3303, numbered according to the sequence of LIT22)Scale bars represent nucleotide substitutions per site.
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