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Volume 10, Number 6—June 2004
Perspective

Chronic Wasting Disease and Potential Transmission to Humans

Ermias D. Belay*Comments to Author , Ryan A. Maddox*, Elizabeth S. Williams†, Michael W. Miller‡, Pierluigi Gambetti§, and Lawrence B. Schonberger*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †University of Wyoming, Laramie, Wyoming, USA; ‡Colorado Division of Wildlife, Fort Collins, Colorado, USA; §Case Western Reserve University, Cleveland, Ohio, USA

Main Article

Table 2

Creutzfeldt-Jakob disease patients investigated for a possible causal link of their illness with chronic wasting disease of deer and elk, United Statesa

Case no. Age at death (y) Year of death Codon 129 Western blot Final diagnosis Eating of venison from CWD-endemic area
1
 25
 2001
 M/V
 Type 1
 GSS 102
 Yes
2
 26
 2001
 M/M
 Type 2
 CJD
 No
3b
 28
 2002
 nd
 nd
 GSS 102
 No
4
 28
 1997
 M/M
 nd
 CJD
 No
5
 28
 2000
 M/V
 Type 1
 CJD
 No
6
 30
 1999
 V/V
 Type 1
 CJD
 No
7
 54
 2002
 V/V
 Type 2
 CJD
 No
8c
 55
 1999
 M/M
 Type 1
 CJD
 No
9d
 61
 2000
 M/M
 Type 1
 CJD
 Yes
10
 63
 2002
 V/V
 Type 1
 CJD
 No
11e
 64
 2002
 M/M
 Type 1
 CJD
 Yes
12 66 2001 M/M Type 1 CJD No

aCWD, chronic wasting disease; GSS, Gerstmann-Sträussler-Scheinker syndrome; CJD, Creutzfeldt-Jakob disease; nd, not done.
bImmunohistochemical analysis of postmortem brain tissue was consistent with GSS, and a GSS 102 mutation was confirmed in the family.
cInvestigated as part of a cluster of three case-patients who participated in “wild game feasts” in a cabin owned by one of the decedents.
dPatient grew up in an area known to be endemic for CWD and ate venison harvested locally; however, the CJD phenotype fits the most common form of sporadic CJD.
ePatient may have been successful in harvesting two deer since 1996 from a CWD-endemic area, but both deer tested negative for CWD.

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Page created: February 22, 2011
Page updated: February 22, 2011
Page reviewed: February 22, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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