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Volume 15, Number 4—April 2009
THEME ISSUE
The Amazon Region
Dispatches

Seroprevalence of Kaposi Sarcoma–associated Herpesvirus and Other Serologic Markers in the Brazilian Amazon

Maria C. NascimentoComments to Author , Laura M. Sumita, Vanda U. Souza, Helen A. Weiss, Juliane Oliveira, Melissa Mascheretti, Mariana Quiroga, Rodrigo A.R. Vela, Nuno R. Faria, Claudio S. Pannuti, and Philippe Mayaud
Author affiliations: Universidade de São Paulo, São Paulo, Brazil (M.C. Nascimento, L.M. Sumita, V.U. Souza, J. Oliveira, M. Mascheretti, M. Quiroga, R.A.R. Vela, E. Sabino, C.S. Pannuti); London School of Hygiene and Tropical Medicine, London, UK (M.C. Nascimento, H.A. Weiss, P. Mayaud)

Main Article

Table 1

Seroprevalence of KSHV among 3 populations in the Brazilian Amazon*†

Variables Mapuera Amerindians, n = 339†
Mapuera non-Amerindians, n = 181†
Manaus blood donors, n = 1,133†
% KSHV positive (no. tested) OR (95% CI) % KSHV positive (no. tested) OR (95% CI) % KSHV positive (no. tested) OR (95% CI)
Sex
Male 79.2 (144) 1 26.7 (75) 1 28.6 (874) 1
Female 82.6 (195) 1.2 (0.7–2.1) 27.4 (106) 1.0 (0.5–2.0) 34.4 (259) 1.3 (1.0–1.7)
p value

0.4


0.1


0.08
Age group, y
0–9 65.0 (43) 0.1 (0.05–0.4) 9.8 (51) 0.1 (0.03–0.3)
10–17 70.0 (93) 0.2 (0.07–0.4) 22.5 (40) 0.3 (0.1–0.7)
18–34 86.5 (104) 0.5 (0.2–1.3) 27.3 (44) 0.4 (0.1–0.9) 29.6 (916) 0.9 (0.7–1.3)
>35 92.9 (99) 1 50.0 (46) 1 31.3 (217) 1
p for trend

<0.001


<0.001



Crowding‡
1–2 93.7 (16) 1 55.6 (9) 1 32.6 (175) 1
3 91.3 (23) 0.7 (0.06–8.4) 33.3 (15) 0.4 (0.07–2.2) 29.9 (941) 0.9 (0.6–1.2)
>4 79.7 (300) 0.3 (0.03–2.0) 24.8 (145) 0.3 (0.07–1.3) 6.2 (16) 0.4 (0.2–1.0)
p value

0.1


0.1


0.1
Ethnicity
African 29.6 (743) 1
Caucasian 30.5 (308) 1.0 (0.8–1.4)
Indigenous 100 (339) 53.8 (13 2.8 (0.9–8.3)
Other 100 (181) 25.8 (66) 0.8 (0. 5–1.5)
p value







0.08
Hepatitis A virus
Negative 83.3 (6) 1 12.5 (16) 1 42.9 (7)§ 1
Positive 81.1 (333) 0.9 (0.1–7.5) 28.5 (165) 2.8 (0.6–12.7) 28.6 (154)§ 0.5 (0.1–2.5)
p value

0.9


0.2


0.4
Hepatitis B virus
Negative 81.6 (315) 1 32.0 (75)§ 1 30.2 (1,075) 1
Positive 73.9 (23) 0.6 (0.2–1.7) 53.3 (15)§ 2.4 (0.8–7.5) 25.0 (56) 0.8 (0.4–1.4)
p value

0.4


0.1


0.4
Hepatitis C virus
Negative 81.0 (338) 36.0 (90)† 29.9 (1,129) 1
Positive 0 0 25.0 (4) 0.8 (0.1–7.5)
p value







0.8
HSV-2
Negative 81.5 (314) 1 18.1 (127) 1 27.8 (715) 1
Positive 76.0 (25) 0.7 (0.3–1.9) 48.1 (54) 4.2 (2.1–8.5) 33.2 (406) 1.3 (1.0–1.7)
p value

0.5


<0.001


0.06
Trepomena pallidum
Negative 81.0 (338) 26.3 (171) 1 29.9 (1,122) 1
Positive 0 40.0 (10) 1.9 (0.5–6.9) 36.4 (11) 1.2 (0.6–2.3)
p value 0.3 0.7

*Seroreactivity by any serologic assay, whole virus. KSHV, Kaposi sarcoma–associated herpesvirus; OR, odds ratio; CI, confidence interval; HSV-2, herpes simplex virus type 2.
†Some figures do not add up to the total because of missing data.
‡Number of residents living in the house.
§Only a random subsample tested.

Main Article

Page created: December 10, 2010
Page updated: December 10, 2010
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