Volume 16, Number 2—February 2010
Dispatch
Severe Leptospirosis in Hospitalized Patients, Guadeloupe
Cécile Herrmann-Storck
, Magalie Saint Louis, Tania Foucand, Isabelle Lamaury, Jacqueline Deloumeaux, Guy Baranton, Maurice Simonetti, Natacha Sertour, Muriel Nicolas, Jacques Salin, and Muriel Cornet
, Magalie Saint Louis, Tania Foucand, Isabelle Lamaury, Jacqueline Deloumeaux, Guy Baranton, Maurice Simonetti, Natacha Sertour, Muriel Nicolas, Jacques Salin, and Muriel Cornet
Table 2
Laboratory findings for 168 case-patients with confirmed leptospirosis, Hospital of Pointe-à-Pitre, Guadeloupe, French West Indies, 2003–2004*
| Laboratory findings | Univariate analysis |
Multivariate analysis |
|||||
|---|---|---|---|---|---|---|---|
| All case-patients, N = 168† | Case-patients with severe disease, n = 24† | Case-patients with nonsevere disease, n = 144† | p value | ||||
| OR (95% CI) | p value | ||||||
| Prothrombin time <70% | 10/118 (8.5) | 5/21 (23.8) | 5/97 (5.1) | 0.01 | 0.7 (0.05–9.8) | 0.077 | |
| Thrombocytopenia, <50 × 109 cells/L | 25/135 (18.5) | 8/23 (34.8) | 17/112 (15.2) | 0.02 | 1 (0.1–2.4) | 0.96 | |
| Hyperneutrophilia, >12 × 109 cells/L | 24/136 (17.6) | 10/23 (43.5) | 14/113 (12.4) | 0.01 | 0.9 (0.1–7.1) | 0.93 | |
| ALT >119 U/L | 30/108 (27.8) | 6/23 (26.1) | 24/85 (28.2) | 0.8 | |||
| AST >102 U/L | 58/128 (45.3) | 17/23 (73.9) | 41/105 (39) | 0.02 | 4.3 (1.2–14.6) | 0.021 | |
| CPK >1000 U/L | 22/108 (20.4) | 5/18 (27.8) | 17/90 (18.9) | 0.4 | |||
| LDH >800 U/L | 11/101 (10.9) | 3/17 (17.6) | 8/84 (9.5) | 0.3 | |||
| Amylase >285 U/L | 16/82 (19.5) | 8/15 (53.3) | 8/67 (11.9) | <0.001 | 18.5 (3.8–88.8) | <0.001 | |
| Lipase >60 U/L |
7/40 (17.5) |
2/8 (25) |
5/32 (15.6) |
0.8 |
|||
| Hemoglobin, g/dL | 12.9 ± 0.6 (136) | 11.1 ± 2.0 (23) | 13.2 ± 3.4 (113) | 0.01 | |||
| Hemoglobin <10 g/dL |
13/136 (9.5) |
5/23 (21.7) |
8/113 (7.1) |
0.04 |
2.3 (0.5–9.8) |
0.2 |
|
| Bilirubin, mg/dL | 8.3 ± 2.3 (86) | 15.2 ± 11.7 (18) | 5.8 ± 7.2 (68) | <0.001 | |||
| Bilirubin >7 mg/dL |
31/86 (36.0) |
13/18 (72.2) |
18/68 (26.4) |
<0.001 |
0.48 (0.05–4.7) |
0.6 |
|
| Potassium, mmol/L | 4.0 ± 0.22 (136) | 3.8±.9 (23) | 4.0 ± 1.3 (113) | 0.5 | |||
| Sodium, mmol/L |
133.5 ± 4.2 (136) |
132.8 ± 5.3 (23) |
133.6 ± 3.9 (113) |
0.5 |
|||
| Creatinine, mg/d | 2.0 ± 0.3 (130) | 2.8 ± 2.5 (21) | 1.9 ± 2.0 (109) | 0.05 | 2.0 (0.6–6.6) | 0.2 | |
| Creatinine >1.5 mg/dL |
54/130 (41.5) |
11/21 (52.4) |
43/109 (39.4) |
0.2 |
|||
| Urea nitrogen mg/dL |
69.0 ± 10.2 (136) |
85.8 ± 76.2 (23) |
64.2 ± 64.2 (113) |
0.5 |
|||
| Isolation of Leptospira in blood culture | 55/88 (62.5) | 8/14 (57.1) | 47/74 (63.5) | 0.3 | |||
| L. interrogans serovar Icterohemorrhagiae | 18/40‡ (45) | 6/8 (75) | 12/32 (37.5) | 0.06 | 5.3 (1.0–26.0) | 0.004 | |
| L. borgpetersenii serovar Castellonis | 5/40‡ (12.5) | 0/8 | 5/32 (15.6) | 0.1 | |||
| L. borgpetersenii serovar Arborea | 9/40‡ (22.5) | 2/8 (25) | 7/32 (21.9) | 0.6 | |||
| L. kirschneri serovar Bogvere | 6/40‡ (15) | 0/8 | 6/32 (18.7) | 0.1 | |||
| L. santarosai serovar Tabaquite | 2/40‡ (5) | 0/8 | 2/8 (25) | 0.4 | |||
*OR, odds ratio; CI, confidence interval; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CPK, creatinine phosphokinase; LDH, lactate dehydrogenase. Boldface indicates significance.
†Mean ± SD (examined) or no. case-patients/no. examined (%).
‡Serovar identification was completed for 40 of the 55 Leptospira strains isolated.
Page created: December 10, 2010
Page updated: December 10, 2010
Page reviewed: December 10, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.