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Volume 16, Number 5—May 2010
Dispatch

Vitamin D Deficiency and Tuberculosis Progression

Najeeha Talat, Sharon Perry, Julie Parsonnet, Ghaffar Dawood, and Rabia HussainComments to Author 
Author affiliations: Aga Khan University, Karachi, Pakistan (N. Talat, R. Hussain); Stanford University School of Medicine, Stanford, California, USA (S. Perry, J. Parsonnet); Masoomeen General Hospital, Karachi, Pakistan (G. Dawood)

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Figure 1

Levels of vitamin D in plasma in the Karachi, Pakistan, tuberculosis (TB) household cohort (7) by TB status at baseline (disease-free, index TB case-patient, coprevalent TB case-patient, and past TB case-patient, treated 2–10 years previously). One disease-free contact was excluded because of an indeterminate test result. Box plots show the median, 25th, and 75th quartiles of serum vitamin D estimated for each group (A) by any TB diagnosis (current or past) at baseline (B) and by sex (C). Refere

Figure 1. Levels of vitamin D in plasma in the Karachi, Pakistan, tuberculosis (TB) household cohort (7) by TB status at baseline (disease-free, index TB case-patient, coprevalent TB case-patient, and past TB case-patient, treated 2–10 years previously). One disease-free contact was excluded because of an indeterminate test result. Box plots show the median, 25th, and 75th quartiles of serum vitamin D estimated for each group (A) by any TB diagnosis (current or past) at baseline (B) and by sex (C). Reference lines represent cut-offs for insufficient and sufficient vitamin D levels, respectively. The Mann-Whitney U test was used for comparison of medians.

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References
  1. Rook  GA. The role of vitamin D in tuberculosis. Am Rev Respir Dis. 1988;138:768–70.PubMedGoogle Scholar
  2. Davies  PD, Brown  RC, Woodhead  JS. Serum concentrations of vitamin D metabolites in untreated tuberculosis. Thorax. 1985;40:187–90. DOIPubMedGoogle Scholar
  3. Nnoaham  KE, Clarke  A. Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. Int J Epidemiol. 2008;37:113–9. DOIPubMedGoogle Scholar
  4. Martineau  AR, Wilkinson  KA, Newton  SM, Floto  RA, Norman  AW, Skolimowska  K, IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J Immunol. 2007;178:7190–8.PubMedGoogle Scholar
  5. Ralph  AP, Kelly  PM, Anstey  NM. L-arginine and vitamin D: novel adjunctive immunotherapies in tuberculosis. Trends Microbiol. 2008;16:336–44. DOIPubMedGoogle Scholar
  6. Crowle  AJ, Ross  EJ, May  MH. Inhibition by 1,25(OH)2-vitamin D3 of the multiplication of virulent tubercle bacilli in cultured human macrophages. Infect Immun. 1987;55:2945–50.PubMedGoogle Scholar
  7. Hussain  R, Talat  N, Shahid  F, Dawood  G. Longitudinal tracking of cytokines after acute exposure to tuberculosis: association of distinct cytokine patterns with protection and disease development. Clin Vaccine Immunol. 2007;14:1578–86. DOIPubMedGoogle Scholar
  8. Zuberi  LM, Habib  A, Haque  N, Jabbar  A. Vitamin D deficiency in ambulatory patients. J Pak Med Assoc. 2008;58:482–4.PubMedGoogle Scholar
  9. Gibney  KB, MacGregor  L, Leder  K, Torresi  J, Marshall  C, Ebeling  PR, Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immigrants from sub-Saharan Africa. Clin Infect Dis. 2008;46:443–6. DOIPubMedGoogle Scholar
  10. Masood  SH, Iqbal  MP. Prevalence of vitamin D deficiency in South Asia. Pak J Med Sci. 2008;24:891–7.
  11. Khan  AH, Iqbal  R. Vitamin D deficiency in an ample sunlight country. J Coll Physicians Surg Pak. 2009;19:267–8.PubMedGoogle Scholar
  12. Holick  MF. Vitamin D deficiency. N Engl J Med. 2007;357:266–81. DOIPubMedGoogle Scholar
  13. Liu  PT, Stenger  S, Li  H, Wenzel  L, Tan  BH, Krutzik  SR, Toll-like receptor triggering of a vitamin D–mediated human antimicrobial response. Science. 2006;311:1770–3. DOIPubMedGoogle Scholar
  14. Martineau  AR, Honecker  FU, Wilkinson  RJ, Griffiths  CJ. Vitamin D in the treatment of pulmonary tuberculosis. J Steroid Biochem Mol Biol. 2007;103:793–8. DOIPubMedGoogle Scholar
  15. Wejse  C, Gomes  VF, Rabna  P, Gustafson  P, Aaby  P, Lisse  IM, Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med. 2009;179:843–50. DOIPubMedGoogle Scholar

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