Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 16, Number 7—July 2010
Dispatch

Vaccine-associated Paralytic Poliomyelitis in Immunodeficient Children, Iran, 1995–2008

Shohreh Shahmahmoodi, Setareh Mamishi, Asghar Aghamohammadi, Nessa Aghazadeh, Hamideh Tabatabaie, Mohammad Mehdi Gooya, Seyed Mohsen Zahraei, Taha Mousavi, Maryam Yousefi, Kobra Farrokhi, Masoud Mohammadpour, Mahmoud Reza Ashrafi, Rakhshandeh Nategh, and Nima ParvanehComments to Author 
Author affiliations: Tehran University of Medical Sciences, Tehran, Iran (S. Shahmahmoodi, S. Mamishi, A. Aghamohammadi, N. Aghazadeh, H. Tabatabaie, M. Yousefi, K. Farrokhi, M. Mohammadpour, R. Nategh, N. Parvaneh); Ministry of Health Center for Disease Control and Management, Tehran (M.M. Gooya, S.M. Zahraei, T. Mousavi); Pediatrics Center of Excellence, Tehran (S. Mamishi, A. Aghamohammadi, M. Mohammadpour, M.R. Ashrafi, N. Parvaneh)

Main Article

Table 1

Age at time of paralysis onset, vaccination history, and characterization of isolated polioviruses, for patients with vaccine-associated paralytic poliomyelitis, Iran, 1995–2008*

Patient no.
 Age, mo/sex at VAPP onset
 OPV, no. doses
 Time intervals Poliovirus type
 Viral protein 1 nt divergence,† %
Last OPV and
VAPP onset
 Virus shedding from VAPP onset
 VAPP onset and death
1 17/F 0‡ 0 1.2 mo 8 d iVDPV type 2 2.2
2 7/M 4 1.1 mo 3 mo 4 mo iVDPV type 2 1.1–1.5
3 10/M 4 3.3 mo 2 wk 1 mo iVDPV type 2 1.7
4 15/M 4 9 mo 5 mo 11 mo iVDPV type 3 2
5 5/F 2 3.2 mo 5 d 1 mo iVDPV type 2, iVDPV type 1 Type 2: 1.7–2; type 1: 1.7
6 20/M 4 1.1 mo 3 d NA§ iVDPV type 2 1.2

*VAPP, vaccine-associated paralytic poliomyelitis; OPV, oral polio vaccine; iVDPV, immunodeficiency-associated vaccine-derived polioviruses.
†From the prototype Sabin strain.
‡Inactivated polio vaccine was administered. Contact case-patient of a healthy OPV-vaccinated sibling.
§Alive to date, has residual paralysis.

Main Article

Page created: March 02, 2011
Page updated: March 02, 2011
Page reviewed: March 02, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external