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Volume 10, Number 2—February 2004
2004 SARS Edition

Clinical Study

Combining Clinical and Epidemiologic Features for Early Recognition of SARS

John A. Jernigan*Comments to Author , Donald E. Low†, and Rita F. Helfand*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †University of Toronto, Ontario, Canada

Main Article

Table 1

Common clinical features of severe acute respiratory syndrome (SARS)

Clinical feature Common findings with SARS-associated coronavirus infection
Initial symptoms
Nonrespiratory prodrome lasting 2–7 days characterized by one or more of the following:
Respiratory phase beginning 2–7 days after onset characterized by:
          Nonproductive cough
          Absence of upper respiratory symptoms
Normal or low total leukocyte cell count


Mildly depressed platelet count

Elevated lactate dehydrogenase levels
Elevated creatine phosphokinase levels
Elevated transaminase levels
Prolonged activated partial thromboplastin time
Radiographic Abnormal chest x-ray in almost all patients by the second week of illness

Main Article