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Volume 10, Number 6—June 2004


Predominant Tuberculosis Spoligotypes, Delhi, India

Urvashi Balbir Singh*, Naga Suresh*, N.Vijaya Bhanu*, Jyoti Arora*, Hema Pant*, Sanjeev Sinha*, Ram Charan Aggarwal*, Sushma Singh*, Jitendra Nath Pande*, Christophe Sola†, Nalin Rastogi†, and Pradeep Seth*
Author affiliations: *All India Institute of Medical Sciences, New Delhi, India; †Institut Pasteur de Guadeloupe, Pointe-à-Pitre, Guadeloupe

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Table 2

Predominant spoligotype prevalent in Delhi and shared type designations for 10 unique isolates, clade designation, and initial description (reference)

Spoligotype designation Spoligotype pattern Cladea Reference
Predominant spoligotype
Type 26 formula image Casi (Delhi) 13
Type 54 formula image Manu 5
Type 1 formula image Beijing 10
Shared spoligotype
Type 50 formula image H3 4
Type 52 formula image T2 4
Type 53 formula image T1 4
Type 138 formula image Eai 4
Type 141 formula image Cas1 5
Type 357 formula image Cas1 5
Type 381 formula image Cas1 4
Type 427 formula image Cas1 5
Type 458 formula image Eai 5,14
Type 1093 formula image Cas 4

aClades were defined according to the definitions in spolDB3.0 (6); = no hybridization, = positive hybridization. CAS1 (Central Asian 1) family (also termed as the "Delhi type") is characterized by 4–7 and 23–34; Manu (derived from the name of a Hindu mythological figure supposed to be the world's first king and father of the human race) is characterized by 33–34 (5), and presumed to be the probable ancestor of both the CAS and EAI (East African Indian). Beijing family is characterized by 1–34. Both EAI and CAS1 belong to the Major Genetic Group 1; H3 (Haarlem 3) belongs to the Major Genetic Group 2; and T1 and T2 are poorly defined families that belong to the Major Genetic Group 2 or 3 (11). T1 and T2 need other markers for a better characterization (T1, 33–36 and T2, 33–36 and 40 [6]).

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