Volume 11, Number 6—June 2005
Dispatch
Cephalosporin and Ciprofloxacin Resistance in Salmonella, Taiwan
Table 2
Characteristics of 20 Salmonella isolates resistant to extended-spectrum cephalosporins
| Serotype | Specimen type | pI (s) | Resistance pattern* | gyrA at position† |
|||
|---|---|---|---|---|---|---|---|
| 83 (TCC [Ser]) | 87 (GAC [Asp]) | parC at position 80 (AGC [Ser])‡ | Isolate (restriction pattern of transferred blaCMY-2+ plasmid)§ | ||||
| Albany | Urine | 9.0 | Am ESC Fx Cm Na Sxt Tc† | – | AAC (Asn) | – | SA04.028 (C) |
| Cairo | Stool | 9.0, 5.4 | Am ESC Fx Cm Na Gm Km Sxt Tc† | TTC (Phe) | – | – | NC04.001 (H1), NC04.002 (H1), NC04.003 (H1) |
| Urine | 9.0 | Am ESC Fx Cm Cp Na Sxt Tc | TTC (Phe) | GGC (Gly) | AAC (Arg) | NC04.004 (H2) | |
| Chester | Stool | 9.0 | Am ESC Fx | – | – | – | NG04.016 (G) |
| Choleraesuis | Wound | 9.0, 5.4 | Am ESC Fx Cm Cp Na Gm Km Sxt Tc | TTC (Phe) | AAC (Asn) | ATC (Ile) | NL04.050 (B) |
| Blood | 9.0, 5.4 | Am ESC Fx Cm Cp Na Gm Tc | TTC (Phe) | AAC (Asn) | ATC (Ile) | SB04.003 (A) | |
| Blood | 9.0, 5.4 | Am ESC Fx Cm Cp Na Gm Km Sxt Tc | TTC (Phe) | AAC (Asn) | ATC (Ile) | SE04.005 (F), SG04.060 | |
| Blood | 9.0, 5.4 | Am ESC Fx Cm Cp Na Gm Km Sxt | TTC (Phe) | AAC (Asn) | ATC (Ile) | SG04.039 (E1), SG04.086 | |
| Joint fluid | 9.0, 5.4 | Am ESC Fx Cm Cp Na Gm Km Sxt Tc | TTC (Phe) | AAC (Asn) | ATC (Ile) | SG04.042 (E2), SG04.047 (E4) | |
| Kaduna | Tissue | 9.0, 5.4 | Am ESC Fx Cm Cp Na Sxt Tc | TTC (Phe) | AAC (Asn) | ATC (Ile) | CE04.015 (I) |
| Saintpaul | Stool | 9.0 | Am ESC Fx Gm | – | – | – | NG04.011 (G), NG04.018 (G) |
| Stanley | Stool | 9.0, 5.4 | Am ESC Fx Cm Sxt Tc | – | – | – | CG04.039 (D) |
| Stool | 9.0 | Am ESC Fx Cm Sxt Tc | – | – | – | NB04.022 (A), SE04.006 (E3) | |
*Am, ampicillin; ESC, extended-spectrum cephalosporins; Fx, cefoxitin; Cm, chloramphenicol, Cp, ciprofloxacin; Na, nalidixic acid; Gm, gentamicin; Km, kanamycin; Sxt, trimethoprim-sulfamethoxazole; Tc, tetracycline.
†The S. Albany isolate and the 3 S. Cairo isolates showed decreased susceptibilities to ciprofloxacin (MIC 0.25–1 μg/mL).
‡Nucleotide and amino acid changes at the QRDRs of gyrA and parC. –, no alterations in the genes.
§For each isolate, the first letter indicates region (C, central region; N, northern region; S, southern region), and the second letter represents hospital. Isolates NC04.001, NC04.002, and NC04.003 were from the same patients; all other isolates were from different patients.