Volume 11, Number 6—June 2005
Dispatch
Rifampin-resistant Meningococcal Disease
Jean Rainbow*
, Elizabeth Cebelinski*, Joanne Bartkus*, Anita Glennen*, Dave Boxrud*, and Ruth Lynfield*
, Elizabeth Cebelinski*, Joanne Bartkus*, Anita Glennen*, Dave Boxrud*, and Ruth Lynfield*
Table 1
Rifampin phenotype and genotype of Neisseria meningitidis isolates
| Strain | Description | Rifampin MIC (μg/mL) | Amino acid change* |
|---|---|---|---|
| MDH02-2342 | Sporadic rifampin-susceptible serogroup C case isolate | 0.004† | None (WT) |
| MDH02-2271 | Sporadic rifampin-susceptible serogroup B case isolate | <0.002† | None (WT) |
| MDH97-498 | Isolate from sporadic rifampin-resistant serogroup B case in 1996 | >4,† >32‡ | His552Tyr§ |
| MDH02-2398 | First sibling's isolate: rifampin susceptible, serogroup C | 0.008† | None (WT) |
| MDH02-2408 | Second sibling's isolate: rifampin resistant, serogroup C | >1,† >32‡ | Ser548Phe§ |
*WT, wildtype.
†Determined by broth microdilution.
‡Determined by Etest.
§Numbering based on the entire N. meningitidis rpoB gene (GenBank accession no. Z54353). Accession numbers of isolate sequences submitted to GenBank: MDH02-2342 (AY746965), MDH02-2271 (AY746964), MDH97-498 (AY746963), MDH02-2398 (AY746966), MDH02-2408 (AY746967).
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