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Volume 11, Number 9—September 2005

Multidrug-resistant Tuberculosis Detection, Latvia

Girts Skenders*, Alicia M. Fry†, Inga Prokopovica*, Silvija Greckoseja*, Lonija Broka*, Beverly Metchock†, Timothy H. Holtz†, Charles D. Wells†Comments to Author , and Vaira Leimane*
Author affiliations: *State Centre of Tuberculosis and Lung Diseases, Riga, Latvia; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table 1

Comparison of results from line probe assay for rpoB gene mutations to rifampin susceptibility results on acid-fast bacilli–positive respiratory specimens*†

Line probe rpoB gene mutation results BACTEC 460 System
Rifampin-resistant Rifampin-susceptible
Resistant 31 1
Susceptible 2 52
No amplification 1 1

*N = 88; Includes 86 Mycobacterium tuberculosis isolates from BACTEC plus 2 isolates that grew on Löwenstein-Jensen media.
†Compared to results from BACTEC drug susceptibility testing, the line probe assay had a sensitivity of 91% (95% confidence interval [CI] 83–99) and a specificity of 96% (95% CI 92–100). The positive predictive value of the line probe rpoB mutation result for rifampin resistance was 94% (95% CI 88–100), and the negative predictive value was 96% (95% CI 92–100).

Main Article

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Page updated: April 23, 2012
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