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Volume 11, Number 9—September 2005

Variant Creutzfeldt-Jakob Disease Death, United States

Ermias D. Belay*Comments to Author , James J. Sejvar*, Wun-Ju Shieh*, Steven T. Wiersma†, Wen-Quan Zou‡, Pierluigi Gambetti‡, Stephen Hunter*, Ryan A. Maddox*, Landis Crockett†, Sherif R. Zaki*, and Lawrence B. Schonberger*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Florida Department of Health, Tallahassee, Florida, USA; ‡Case Western Reserve University, Cleveland, Ohio, USA

Main Article


Estimated range of incubation periods for variant Creutzfeldt-Jakob disease cases with presumed route and year of exposure*

Presumed route of exposure and country of residence† Period of potential BSE/vCJD exposure Estimated range of incubation period (y)
Canada 1987–1990 11–14
Ireland 1989–1995 5–10
Japan‡ 1989 12
United Kingdom (Leicestershire, England) 1980–1985 10–16
United States 1980–1992 9–21
United Kingdom 1996 6.5
United Kingdom§ 1999 >5

*BSE/vCJD, bovine spongiform encephalopathy/variant Creutzfeldt-Jakob disease.
†Estimated range of incubation periods are based on a single vCJD case except for Leicestershire, England, where the Leicestershire Health Authority reported the estimated incubation period for a cluster of 5 vCJD cases.
‡Patient was reported to have stayed in the United Kingdom ≈24 days.
§Patient with presumed bloodborne transmission died of a nonneurologic disease. The presence of the vCJD agent was detected in the spleen and cervical lymph node; the patient was heterozygous for methionine and valine at the polymorphic codon 129 of the prion protein gene.

Main Article

Page created: April 23, 2012
Page updated: April 23, 2012
Page reviewed: April 23, 2012
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